Internal jugular vein collapsibility to gauge volume status in preeclampsia vs. normal pregnancy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares intravascular volume indicators obtained from internal jugular vein ultrasound between preeclamptic and normotensive parturients at 28–40 weeks undergoing elective cesarean section. It aims to identify non-invasive, bedside measures that reflect volume status and contrast them between the two groups. The approach seeks to improve perioperative fluid guidance and reduce risks related to hypovolemia or fluid overload in preeclampsia. The study notes limitations of invasive monitoring and challenges of ultrasound in pregnancy, proposing IJV indices as a practical alternative. No interventional manipulation is described; data collection centers on imaging-based measurements and clinical correlations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Singleton parturients from 18 to 40 years old.
2. Either normotensive or preeclamptic parturients scheduled for elective cesarean section under neuro-axial block matched for gestational age 28-40 weeks will be included:
3. Normotensive group: uncomplicated normotensive pregnancy with systolic blood pressure below 140 mmHg and diastolic blood pressure below 90mmHg without proteinuria.
4. Preeclamptic Group: new onset preeclamptic pregnant female with gestational hypertension after 20 weeks of pregnancy diagnosed based on ISSHP Guidelines: systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg, accompanied by one or more of the following:

   * Proteinuria (≥300 mg in a 24-hour urine sample)
   * Alb/Cr ratio ≥30 mg/mmol,
   * Organ dysfunction (renal insufficiency (creatinine level\>1.1mg%), liver involvement (liver enzyme levels ≥3 times normal), neurological complications (Headache and blurring of vision) and hematological involvement (thrombocytopenia\<100.000)).

Exclusion Criteria:

1. Parturients with pre-existing cardiac \& vascular disease affecting blood volume and vascular compliance: (Valvular or congenital heart disease, arrhythmia, previous history of venous thromboembolism, chronic kidney disease, gestational diabetes).
2. multiple gestations
3. known thyroid disorders or chronic hypertension
4. patients with BMI \>40 and patients requiring emergency delivery.

Where it's running

• Tanta University Hospital
  Tanta, El-Gharbia Govenorate, Egypt Recruiting

Study contacts

• Study coordinator: Abdelghany AA Mohamed, MBBCH
• Email: Aldomiaty97@gmail.com
• Phone: +201123676274

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.