Preeclampsia risk in early pregnancy and long-term heart health in women with type 1 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter observational study in Spain that looks at adults with type 1 diabetes who had at least one pregnancy and a first-trimester preeclampsia screen. Researchers classify participants as high or low risk for preeclampsia and examine carotid artery health, metabolic risk factors, and any cardiovascular events years after delivery. Data are collected during a single study visit through medical records, exams, questionnaires, and carotid ultrasound where available. The study also explores glycemic metrics from continuous glucose monitoring and the potential protective role of aspirin against clinical preeclampsia. Overall, the goal is to understand if early pregnancy risk signals long-term cardiovascular risk beyond the occurrence of PE itself.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Confirmed diagnosis of type 1 diabetes
* At least one prior pregnancy with first-trimester preeclampsia screening (\<14 weeks gestation)
* ≥3 years since last pregnancy

Exclusion Criteria:

* Previous multiple pregnancy
* Cardiovascular disease before pregnancy (coronary heart disease, stroke/TIA, peripheral artery disease, heart failure)
* Active pregnancy at time of evaluation
* Alcohol or substance dependence (except nicotine/caffeine) in the last 3 years
* Active severe psychiatric disease, dementia, severe disability, or reduced life expectancy

Where it's running

• Hospital Clínic Barcelona
  Barcelona, Barcelona, Spain Recruiting
• Hospital Universitari Mútua Terrassa
  Terrassa, Terrassa, Spain Not yet recruiting

Study contacts

• Study coordinator: Verónica Perea, MD, PhD
• Email: vperea@mutuaterrassa.cat
• Phone: +34 93 736 50 50

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• Hyperspectral imaging to predict preeclampsia risk

  This study will test whether a non-contact camera method called hyperspectral imaging can spot early microcirculation changes and help predict which pregnant people will develop preeclampsia.

  Recruiting Heidelberg University · Heidelberg · NCT07106294

• Examining how aspirin metabolism relates to metabolic dysfunction in pregnant individuals at risk of preeclampsia

  This study is trying to see how the way pregnant people process aspirin relates to their metabolic health and the health of their babies, especially for those at risk of preeclampsia.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT06802861

• Semaglutide on body composition in adults with type 1 diabetes and overweight/obesity

  This study tests whether weekly semaglutide changes body composition in adults with type 1 diabetes who are overweight or obese, compared with a placebo over 24 weeks.

  Recruiting Phase 2/3 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07891156

• Next Generation Extended Wear Sensors in Type 1 and Type 2 Diabetes

  This study tests a new extended wear sensor and algorithm in people with type 1 or type 2 diabetes to see how well it works across adults and children.

  Recruiting at 11 sites Medtronic MiniMed, Inc. · Chula Vista, California and 17 other locations · NCT07864168

• Predicting Adverse Pregnancy Outcomes in Uganda through Partnerships and Innovation

  This study tests whether everyday health data, ultrasound, and blood samples from first-time pregnant women in Uganda can help predict problems like preeclampsia, fetal growth restriction, and preterm birth.

  Recruiting at 2 sites Makerere University · Kampala and 1 other locations · NCT07844876

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.