Gestational hypertension and preeclampsia: better blood pressure targets before delivery
Official title: Gestational hypertension and preeclampsia blood pressure (BP) Treatment goals <140/90 vs. <160/110 mmHg: The GOALPOST Trial
Funded at George Washington University · NIH-11357565 · Data updated 2026-11-12
This study tests whether keeping blood pressure under 140/90 mmHg (instead of 160/110) during pregnancy with high blood pressure improves outcomes for mothers and babies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | July 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $3,106,769 |
| NIH project number | 5U01HD114633-02 |
| Project ID | NIH-11357565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant people with gestational hypertension or preeclampsia without severe features, between the early to mid-pregnancy period, who can be closely monitored.
✕Less likely to help
Patients with severe features or high-risk conditions requiring immediate delivery may not benefit from the tighter targets.
What this research studies
If you are pregnant and have gestational hypertension or preeclampsia without severe symptoms, this trial looks at whether tighter blood pressure control can reduce complications for you and your baby. Participants will receive a BP management plan aiming for a target of 140/90 or 160/110 mmHg, with monitoring and safety checks throughout pregnancy. The study is conducted at George Washington University and will follow you through delivery, tracking outcomes for both mother and newborn. If successful, this approach could change how doctors manage high blood pressure in pregnancy to improve health for families.
Why it matters
Potential benefit: If successful, tighter BP targets could lower risks for the mother and baby and lead to clearer guidelines for treating high blood pressure in pregnancy.
How similar studies have gone: Previous trials in pregnancy have explored BP targets; this study aims to provide clearer evidence for non-severe HDP.
Where this research is happening
-
George Washington University
Washington, United States Active
Researchers
- Principal investigator: Clifton, Rebecca Gersnoviez — George Washington University
- Study coordinator: Clifton, Rebecca Gersnoviez
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.