Condition
Postoperative Complications clinical trials and research
As of November 12, 2026, Find a Trial lists 85 Postoperative Complications clinical trials that are recruiting, at sites in 33 countries (most in China (19), Turkey (Türkiye) (9), United States (8)). 1 was first registered in the last 30 days. By phase: Phase 4 (2), Phase 2/3 (1), Phase 2 (1), Phase 1/2 (1). The most active sponsors are St. Anne's University Hospital Brno, Czech Republic (3), Minia University (3), Hospital Universitari de Bellvitge (2). There are also 2 NIH-funded research projects on Postoperative Complications, with $478,146 in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 85Clinical trials
- 2NIH research projects
- 1New in 30 days
- 33Countries
Newest Postoperative Complications clinical trials
All recruiting trials (85)
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Prehabilitation with Resistance, Aerobic, or Both Before Colorectal Surgery
Four pre-surgery exercise options (resistance, aerobic, both, or none) will be tested to see which best reduces complications after colorectal cancer surgery.
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Axillary Web Syndrome after Breast Cancer Surgery: Incidence, Risk Factors, and Outcomes
This study tests how often AWS occurs after breast cancer surgery and what factors make it more likely, using a forward-looking approach in women undergoing SLNB or ALND.
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Intraoperative Warmth and Moisture for VATS: Do Humidified Gases Help After Thoracic Surgery?
This observational study looks at whether using heated, humidified gases during VATS with one-lung ventilation helps reduce lung-related postoperative problems.
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Predicting liver failure after major liver surgery using CT measurements and vascular shape changes
Doctors are testing whether adding vascular deformation mapping to CT measurements can better predict liver failure after removing a large portion of the liver.
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Hernia Sac Flap Coverage of Mesh in Complex Bony-Edged Ventral Hernias
We’re testing whether using the patient’s own hernia sac as a living flap underneath the mesh helps healing after complex ventral hernia repair when part of the edge is bone.
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Timing of Recruitment Maneuver in Robotic Prostate Surgery
This study tests whether doing a recruitment maneuver before or after CO2 insufflation during robotic prostate surgery helps prevent lung problems afterward.
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Non-Thermal Plasma Used During Surgery to Help Prevent Recurrent Chronic Subdural Hematoma
A randomized trial tests whether applying non-thermal plasma during standard surgery to drain a chronic subdural hematoma can reduce recurrence within 6 months.
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Preoperative Fasting to Shape the Gut with Hip Replacement
This trial tests whether a 20-day preoperative fasting plan can lower inflammatory signals and broaden gut microbes in adults undergoing total hip arthroplasty.
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Wearable device for early warning of postoperative complications after thoracic surgery
A wearable device is used to see if continuous monitoring can spot early signs of problems after thoracic surgery in adults.
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Ventilation During Transport of Mechanically Ventilated Patients After Non-Cardiac Surgery
This observational study looks at how patients who stay intubated after non-cardiac surgery are ventilated during the move from the operating room to the ICU.
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Preoperative Immunonutrition for bone and soft tissue sarcoma patients
This study tests whether a short course of an oral nutrition supplement before surgery can help patients with bone or soft tissue sarcomas recover better after major tumor-related surgery.
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Predicting who will need ICU care after cancer surgery
This study will test common risk scores to see if they can predict which adult cancer surgery patients will need ICU care after their operation.
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Predicting 30-day heart problems after gastrointestinal surgery using AI versus standard risk scores
This project will test whether an AI-based multimodal model can better predict major heart problems within 30 days after gastrointestinal surgery for adults at Bach Mai Hospital than commonly used risk scores.
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Blood Viscosity and Outcomes After Elective Brain Surgery
This study will test whether measures of blood viscosity taken during elective intracranial surgery relate to how patients recover and if they have postoperative complications.
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Can infrared thermography help predict how skin wounds heal after surgery?
This study tests if a harmless infrared camera can spot early signs of wound problems after skin surgery so clinicians can act sooner.
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Predicting post-surgery ICU outcomes using IL-6 and blood-count inflammation scores
This study will test whether IL-6 levels and routine blood-count inflammation scores at ICU admission and 24 hours can help predict complications and in-hospital death for adults after surgery.
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Low calcium after thyroid removal
This project will see if clinical, lab, and surgical factors predict low calcium after thyroid surgery in adults treated at Minia University Hospital from 2014–2024.
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Nurse-led pre-op education with direct physiotherapy referral to reduce leakage after prostate removal
This project sees if a one-to-one nurse-led pre-operative education session plus automatic referral to supervised pelvic floor physiotherapy reduces urinary leakage in men having radical prostatectomy.
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Compliance-guided Closure Strategy for Large Ventral Hernia Repair
This study tests whether using a structured intraoperative plan based on respiratory system stiffness helps decide how to close the abdominal wall in people with large ventral hernias.
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Early post-op blood biomarkers and the risk of delirium after major surgery
We will test whether blood levels of S100B, NSE, IL-6, and Copeptin measured within two hours after surgery can help predict delirium in people 65 and older having major non-cardiac, non-intracranial, non-vascular elective surgery.
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Gamified breathing exercises before surgery to reduce anxiety and emergence delirium in children
This trial will test whether fun, game-like breathing exercises done before surgery reduce preoperative anxiety and emergence delirium in children aged 3–7.
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DeepComp: AI prediction of complications after stomach cancer surgery
This project will try an AI tool called DeepComp to predict which adults with gastric adenocarcinoma scheduled for curative stomach surgery are at high risk of moderate-to-severe postoperative complications using routine preoperative CT scans and clinical data.
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Atrial dyssynchrony to predict arrhythmias after cardiovascular surgery
We will try to see if echocardiogram measurements of atrial dyssynchrony can predict which patients having non-mitral cardiovascular surgery will develop atrial fibrillation after surgery.
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AI prediction of complications after transcatheter closure of perimembranous VSD in children
This project will try an AI model that combines clinical data, text notes, and images to predict which children undergoing transcatheter closure of perimembranous VSD are at higher risk of treatment-related complications.
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Signia circular stapler for left-sided colon, sigmoid, and rectal resections
This study will try the Signia circular stapler with Tri-Staple technology to see if it safely creates bowel reconnections in adults having left-sided colon, sigmoid, or rectal surgery.
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Predicting heart injury after major liver and biliary surgery
We test whether a stepwise prediction model using routine clinical data, the type and timing of liver blood-flow control (SPVO vs Pringle), and simple blood markers can predict heart injury (MINS) after major hepatobiliary surgery in adults.
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Perioperative care and outcomes for older adults having surgery
This project will follow people aged 65 and older who are having surgery to try to identify clinical and biological factors that raise the risk of postoperative delirium and other complications.
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Double-layer vaginal vault closure with self-locking versus traditional sutures after laparoscopic hysterectomy for gynecologic cancer
This trial tests whether double-layer self-locking (barbed) sutures reduce vaginal cuff complications compared with traditional Polyglactin 910 sutures in adults having laparoscopic or robotic hysterectomy for gynecologic cancer.
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Monitoring blood markers during DIEP flap breast reconstruction
We will see if measuring inflammation and oxidative stress markers in blood before and during the first 72 hours after DIEP flap reconstruction helps map recovery patterns for women having immediate breast reconstruction after mastectomy.
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Tea tree oil versus chlorhexidine mouthwash after impacted lower wisdom tooth removal
This tests whether tea tree oil mouthwash can reduce swelling, pain, limited mouth opening, and help gum healing as well as standard chlorhexidine in adults after extraction of impacted lower wisdom teeth.
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Goal-oriented albumin infusion to reduce complications after gastric cancer surgery
This test tries to see if giving albumin when blood levels drop below 25 g/L instead of 30 g/L after gastric cancer surgery reduces serious postoperative complications in adults.
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Post-surgery nutrition shake to help recovery in older adults
We will try a daily nutritional shake after surgery to see if it helps people 70 and older recover their strength and thinking compared with standard postoperative nutrition instructions.
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Using internal jugular vein ultrasound to guide fluids during abdominal surgery
This trial will try using ultrasound measurements of breathing-related changes in the internal jugular vein to guide how much fluid adults aged 20–70 receive during abdominal surgery and see if that lowers postoperative complications.
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Lower leg skin grafts after tumour removal: does negative pressure dressings help or not?
This trial tests whether negative pressure wound therapy over split-thickness skin grafts on the lower leg reduces infection compared with traditional dressings in adults after skin tumour removal.
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Urine Output Monitoring to Guide Fluid and Diuretic Therapy in Cardiac ICU Patients
This observational study tests how continuous urine output data from the FIZE kUO device can help guide fluid therapy and diuretic use in adults after heart surgery.
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Pre-surgery nutrition and inflammation markers and early recovery after sleeve gastrectomy
This project tests whether pre-surgery nutrition and inflammation lab markers (PNI, HALP, NLR, CRP) can help predict early recovery, complications, and hospital stay length in adults having elective laparoscopic sleeve gastrectomy.
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Impact of Nutritional Care on Recovery After Joint Replacement Surgery
This study is testing if better nutritional care before and after hip or knee replacement surgery can help patients recover faster and avoid complications.
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Link between alcohol use and surgical outcomes at University Hospitals
This study is trying to see if higher alcohol use, measured by a specific marker in the blood, affects recovery and complications in patients who have elective surgery and stay in the hospital for a few days.
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Comparing Remimazolam and Propofol for sedation during endoscopic procedures
This study is testing whether using Remimazolam alone, Propofol alone, or a combination of both can provide better and safer sedation for patients undergoing endoscopic procedures.
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Evaluating thumbtack needle therapy for improving sleep and recovery after surgery
This study is testing if thumbtack needle therapy can help women recover better and sleep more soundly after breast cancer surgery.
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Investigation of complications after bariatric surgery in the UK
This study looks at the problems some people face after weight loss surgery in the UK to see how they are treated and what works best for their recovery.
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Using the Fissios App to Improve Recovery After Lung Surgery
This study tests if using the Fissios App can help people recover better and have fewer problems after lung surgery for cancer compared to standard physiotherapy.
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Predicting depression in patients after heart surgery
This study is trying to see if a new tool can help predict which patients might develop depression after heart surgery, so they can get help sooner.
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Assessing exercise capacity in patients undergoing heart surgery
This study is testing if certain exercise measurements can help predict complications and survival in older patients with health issues who are having heart surgery.
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Intensive lifestyle intervention for patients undergoing ventral hernia repair
This study tests if a special program that helps people change unhealthy habits can reduce complications after surgery for ventral hernia repair.
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Assessing complications after skull base tumor surgery
This study is testing if using lung ultrasound can help find patients at risk for breathing problems and blood clots after surgery for skull base tumors.
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Four mouthwash options to help sockets heal after removal of an impacted lower wisdom tooth.
This study will test whether four mouthwashes — Bone Bioactive Liquid, hyaluronic acid, chlorhexidine, or warm saline — help socket healing and improve quality of life after surgical removal of an impacted lower wisdom tooth in adults.
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Evaluating fluid therapy for recovery after head and neck cancer surgery
This study is testing if a special way of giving fluids during surgery can help people recover better after having head and neck cancer surgery.
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Comparing stapler reinforcement patches to standard staplers in gastrojejunostomy procedures
This study tests if using special patches with staplers during gastric cancer surgery can help prevent complications like leaks compared to regular staplers.
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Assessing OSA risk in dental patients undergoing general anesthesia
This study is trying to see how many dental patients who will be put under general anesthesia might have obstructive sleep apnea and if it affects their recovery.
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Assessing surgery risk through a walking test
This study is testing if a six-minute walking test can help predict the risk of complications for patients over 40 who are having non-heart surgery.
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Evaluating risk scores for predicting lung complications after thoracic surgery
This study is testing whether certain risk scores can help predict lung problems after surgery for adults who need single-lung ventilation.
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Evaluating the effects of residual neuromuscular block after surgery
This study looks at how leftover muscle weakness after surgery affects recovery and complications in patients who were given anesthesia with muscle relaxants.
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Using 20% albumin with Ringer's lactate during cytoreductive surgery and HIPEC.
This study will test whether adding 20% albumin to Ringer's lactate during cytoreductive surgery with HIPEC for adults with peritoneal carcinomatosis reduces the need for crystalloid fluids and improves postoperative outcomes.
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Mechanical ventilation in adults during surgery
This study tests how often postoperative lung problems occur in adults who are ventilated during general anesthesia for surgery and explores how ventilation practices relate to those problems.
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Alert frequency and nurse/patient satisfaction with a wireless continuous vital-sign monitoring app
This pilot will test whether a wearable continuous vital-sign monitoring system and its app work well and are acceptable to adult patients and nurses on general wards after surgery or acute medical admission.
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Monitoring postoperative complications in cancer patients with a smart system
This study is testing a smart monitoring system that sends alerts about vital signs to see if it helps high-risk cancer patients recover better after surgery compared to regular monitoring.
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Comparing two imaging techniques for gastrointestinal surgeries
This study is testing two different imaging methods to see which one better helps doctors check blood flow in patients who have had gastrointestinal surgeries.
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Evaluating Enhanced Recovery After Surgery for Pituitary Tumor Patients
This study is testing whether following a special recovery plan after surgery helps people with pituitary tumors heal better and faster.
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Comparing scar outcomes from different incision techniques in mastectomy
This study is testing which type of incision technique during mastectomy leads to the best-looking scars for patients who aren't having immediate breast reconstruction.
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Improving sleep to reduce pain after joint surgery
This study is testing if helping people with insomnia sleep better before knee or hip surgery can reduce their pain after the operation.
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Using individualized ventilation strategies to reduce lung complications after minimally invasive abdominal surgery
This study is testing if a personalized breathing strategy during surgery can help prevent lung problems for people having minimally invasive abdominal surgery.
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Family-centered care to reduce emergency delirium in children after surgery
This study tests if having family members involved during surgery can help young children aged 2-6 experience less confusion and distress when waking up from anesthesia.
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Investigating pain and nausea after gallbladder surgery
This study looks at how common pain and nausea are after gallbladder surgery to see what factors might make these problems worse for patients.
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Using a smartphone app to help lung cancer patients stick to their rehabilitation exercises after surgery
This study is testing whether a smartphone app can help lung cancer patients stick to their rehabilitation exercises after surgery by allowing them to report their symptoms and get feedback from their doctors.
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Observational study on postoperative complications in pediatric surgery in Latin America
This study looks at the complications that can happen after surgery in kids under 18 in Latin America to see how common they are and what might cause them.
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Pain control methods for patients undergoing esophagectomy
This study is testing three different ways to manage pain for patients having minimally invasive esophagectomies to see which one works best.
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Improving preoperative care for pancreatic surgery patients
This study is testing a new health program to see if it helps patients get stronger and recover faster after pancreatic surgery.
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Hypotension Prediction Index for free-flap reconstruction in head and neck surgery
This will test whether using the Hypotension Prediction Index reduces episodes of low blood pressure during free-flap reconstruction for people having head and neck cancer surgery.
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Robot-assisted reconstruction after surgery for rectal or anal cancer
This study is testing if using a muscle flap to rebuild the pelvic floor or vagina after robotic surgery for rectal or anal cancer can improve recovery and quality of life for patients.
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Improving recovery in elderly surgical patients with nutrition and oral care
This study is testing if better nutrition and oral care can help older patients recover more smoothly after surgery and avoid complications.
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Using vancomycin powder to prevent infections after inguinal lymph node dissection
This study is testing if using vancomycin powder during surgery can help prevent infections and other complications for women having lymph node surgery for vulvar cancer.
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Improving recovery in older colorectal cancer patients with sarcopenia
This study is testing if exercise and nutrition can help older colon cancer patients with muscle loss recover better and have fewer infections after surgery.
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Identifying surgical planes in minimally invasive lung surgery using fluorography
This study is testing a new method using special imaging to help surgeons find the right areas to operate on during lung surgery for patients with certain lung issues, aiming to make the surgery quicker and safer.
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Comparing linear and circular staplers for esophagojejunostomy after total gastrectomy
This study is testing whether using linear staplers or circular staplers during surgery can help patients with gastric cancer have fewer complications and shorter hospital stays after having their stomach removed.
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Understanding biomarkers in patients undergoing high-risk surgery
This study is trying to find out if certain blood markers can help predict complications after high-risk surgeries to improve patient care and outcomes.
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Preventing incisional hernias after kidney transplantation
This study is testing if using a special mesh during kidney transplant surgery can help prevent hernias from forming afterward in patients receiving their first transplant.
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Evaluating the effects of showering on postoperative complications with drains
This study is testing if showering with drains after breast reduction or panniculectomy surgery affects the risk of complications for patients.
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Comparing robot-assisted and open surgery for esophageal cancer
This study is testing if robot-assisted surgery for esophageal cancer is as effective or better than traditional open surgery in helping patients recover and live well after the operation.
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Early PONV: Registry Insights from Swedish Perioperative Data
This study uses Swedish registry data to see how often nausea and vomiting happen soon after surgery and what factors are linked to it in adults after different procedures.
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Improving respiratory care for patients having high-risk abdominal surgery
This study is testing whether using a special mouthwash and different amounts of oxygen before surgery can help reduce the chances of pneumonia and infections in patients having major abdominal surgery.
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Managing blood pressure and using dexamethasone during lung cancer surgery
This study is testing if managing blood pressure and giving dexamethasone during lung cancer surgery can help patients recover better and live longer.
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Evaluating lung therapies for patients after heart surgery
This study tests three different breathing therapies to see which one helps patients recover their lung function best after heart surgery.
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Registry to improve outcomes after heart and chest surgeries
This study is collecting information from patients who have heart and chest surgeries to see how different factors affect their recovery and overall outcomes.
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Effects of anesthesia type on recovery after hip fracture surgery in elderly patients
This study is trying to see if using regional anesthesia instead of general anesthesia during hip fracture surgery helps older patients recover better and have fewer health problems afterward.
NIH-funded research (2)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Preoperative risk predictor for cardiac surgery using a smartphone dynamometer
A smartphone app that turns your phone into a hand-grip test to help predict surgical risks before elective heart surgery.
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Using smartphone technology to predict risks of complications after heart surgery
This study is testing a new smartphone app that helps you check your hand grip strength at home, so doctors can better understand your fitness level before elective heart surgery and help you recover more safely.
Related topics
Quick answers
How many Postoperative Complications clinical trials are recruiting right now?
85, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 33 countries. The most sites are in China (19 trials), Turkey (Türkiye) (9 trials), United States (8 trials), Spain (5 trials), Netherlands (4 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 4: 2, Phase 2/3: 1, Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.