Atrial dyssynchrony to predict arrhythmias after cardiovascular surgery
Atrial Electromechanical Alteration as a Predictor of Arrhythmias in the Postoperative Period After Cardiovascular Surgery
We will try to see if echocardiogram measurements of atrial dyssynchrony can predict which patients having non-mitral cardiovascular surgery will develop atrial fibrillation after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 138 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | School of Medicine. National University of Cuyo Academic / other |
| Locations | 1 site (Mendoza, Mendozz) |
| Trial ID | NCT07388108 on ClinicalTrials.gov |
What this trial studies
Patients scheduled for non-mitral cardiovascular surgery who are in sinus rhythm will have a preoperative Doppler echocardiogram with two-dimensional speckle-tracking atrial strain and, when possible, 3D left atrial ejection fraction measurement. Images are obtained in left lateral decubitus with 3 consecutive beats recorded in forced expiration using a Philips EPIC CVx system and analyzed in 2- and 4-chamber views to quantify intra- and inter-atrial dyssynchrony, indexed left atrial volume, and left ventricular ejection fraction by Simpson biplane. Participants are followed during the postoperative hospital stay to record occurrences of atrial fibrillation. The protocol excludes patients with prior atrial fibrillation, mitral or tricuspid valve surgery, congenital heart disease or cardiac tumors, emergency cardiac surgery, or an inadequate echocardiographic window.
Who should consider this trial
Good fit: Ideal candidates are adults in sinus rhythm scheduled for planned non-mitral cardiovascular surgery who can undergo a high-quality preoperative echocardiogram and agree to inpatient follow-up.
Not a fit: Patients with prior atrial fibrillation, undergoing mitral or tricuspid valve procedures, with congenital heart disease or cardiac tumors, having emergency surgery, or with poor echocardiographic windows are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could identify patients at higher risk for postoperative atrial fibrillation so clinicians can target monitoring or preventive measures to reduce complications.
How similar studies have performed: Previous observational work using atrial strain and dyssynchrony measures has shown promise for predicting postoperative atrial fibrillation, but results are heterogeneous and need larger validation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with criteria for non-mitral cardiovascular surgery, in sinus rhythm, and who gave informed consent to participate in the study. * Absence of atrial fibrillation upon hospital admission for surgery. Exclusion Criteria: * Surgery of the mitral or tricuspid valve. * History of previous atrial fibrillation. * History of congenital heart disease or cardiac tumors. * Emergency surgery of the heart * Pour echocardiographic window
Where this trial is running
Mendoza, Mendozz
- Clínica de Cuyo — Mendoza, Mendozz, Argentina (Recruiting)
Study contacts
- Study coordinator: Francisco Sánchez, PhD
- Email: fsanchez@fcm.uncu.edu.ar
- Phone: +5492614135000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.