Low calcium after thyroid removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center retrospective cohort review of all adults who underwent total, subtotal, or completion thyroidectomy at Minia University Hospital between January 1, 2014 and December 31, 2024. Investigators will extract demographics, preoperative labs (calcium, vitamin D, PTH, thyroid tests), surgical details (extent of surgery, lymph node dissection, surgeon experience, operative time, parathyroid identification/autotransplantation), postoperative calcium/PTH measurements, supplementation needs, and pathology findings. Univariate analyses will screen potential predictors and multivariable logistic regression will be used to identify independent risk factors for transient and permanent postoperative hypocalcemia. The goal is to generate local risk stratification data to guide perioperative management and patient counseling.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged 18 years or older at time of surgery
* Underwent thyroidectomy at Minia University Hospital
* Availability of medical records with complete surgical and postoperative data
* Documented serum calcium levels measured postoperatively
* Minimum follow-up of 6 months postoperatively or documented outcome status

Exclusion Criteria:

* Age less than 18 years at time of surgery
* Preoperative hypocalcemia (serum calcium \<8.0 mg/dL or ionized calcium \<1.0 mmol/L)
* Pre-existing parathyroid disorders (primary hyperparathyroidism, hypoparathyroidism, secondary or tertiary hyperparathyroidism)
* Chronic kidney disease Stage 3 or higher (estimated glomerular filtration rate \<60 mL/min/1.73m²)
* Malabsorption syndromes affecting calcium metabolism (celiac disease, inflammatory bowel disease,short bowel syndrome)
* Concurrent planned parathyroidectomy
* History of neck irradiation
* Chronic use of medications significantly affecting calcium metabolism (bisphosphonates, denosumab,cinacalcet, chronic corticosteroids)
* Incomplete medical records lacking essential data including surgical details, postoperative calcium levels,or follow-up data
* Patients lost to follow-up before 6-month endpoint without documented outcome status

Where it's running

• Minia University Hospital
  Minya, Minya Governorate, Egypt Recruiting

Study contacts

• Principal investigator: Saleh K Saleh, MD — Minia University
• Study coordinator: Saleh K Saleh, MD
• Email: salehkhairy@mu.edu.eg
• Phone: 01201765401

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.