Low calcium after thyroid removal
A Ten-Year Cohort Study of Clinical and Surgical Predictors for Hypocalcemia Post-Thyroidectomy
Minia University · NCT07428057
This project will see if clinical, lab, and surgical factors predict low calcium after thyroid surgery in adults treated at Minia University Hospital from 2014–2024.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Minia University (other) |
| Drugs / interventions | denosumab |
| Locations | 1 site (Minya, Minya Governorate) |
| Trial ID | NCT07428057 on ClinicalTrials.gov |
What this trial studies
This is a single-center retrospective cohort review of all adults who underwent total, subtotal, or completion thyroidectomy at Minia University Hospital between January 1, 2014 and December 31, 2024. Investigators will extract demographics, preoperative labs (calcium, vitamin D, PTH, thyroid tests), surgical details (extent of surgery, lymph node dissection, surgeon experience, operative time, parathyroid identification/autotransplantation), postoperative calcium/PTH measurements, supplementation needs, and pathology findings. Univariate analyses will screen potential predictors and multivariable logistic regression will be used to identify independent risk factors for transient and permanent postoperative hypocalcemia. The goal is to generate local risk stratification data to guide perioperative management and patient counseling.
Who should consider this trial
Good fit: Adults (age ≥18) who underwent thyroidectomy at Minia University Hospital between 2014 and 2024 with complete surgical and postoperative records, documented postoperative calcium levels, and at least 6 months of follow-up or a documented outcome.
Not a fit: Patients under 18, those with preexisting parathyroid disorders, chronic kidney disease stage 3 or higher, malabsorption syndromes, prior neck irradiation, concurrent planned parathyroidectomy, chronic medications that strongly affect calcium metabolism, or incomplete records are excluded and unlikely to benefit from this analysis.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify patients at higher risk for post-thyroidectomy low calcium and tailor monitoring and supplementation to reduce symptoms and the chance of permanent hypocalcemia.
How similar studies have performed: Previous retrospective and some prospective studies have identified risk factors for post-thyroidectomy hypocalcemia, so this study mainly provides confirmatory and locally relevant data rather than a novel treatment approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged 18 years or older at time of surgery * Underwent thyroidectomy at Minia University Hospital * Availability of medical records with complete surgical and postoperative data * Documented serum calcium levels measured postoperatively * Minimum follow-up of 6 months postoperatively or documented outcome status Exclusion Criteria: * Age less than 18 years at time of surgery * Preoperative hypocalcemia (serum calcium \<8.0 mg/dL or ionized calcium \<1.0 mmol/L) * Pre-existing parathyroid disorders (primary hyperparathyroidism, hypoparathyroidism, secondary or tertiary hyperparathyroidism) * Chronic kidney disease Stage 3 or higher (estimated glomerular filtration rate \<60 mL/min/1.73m²) * Malabsorption syndromes affecting calcium metabolism (celiac disease, inflammatory bowel disease,short bowel syndrome) * Concurrent planned parathyroidectomy * History of neck irradiation * Chronic use of medications significantly affecting calcium metabolism (bisphosphonates, denosumab,cinacalcet, chronic corticosteroids) * Incomplete medical records lacking essential data including surgical details, postoperative calcium levels,or follow-up data * Patients lost to follow-up before 6-month endpoint without documented outcome status
Where this trial is running
Minya, Minya Governorate
- Minia University Hospital — Minya, Minya Governorate, Egypt (RECRUITING)
Study contacts
- Principal investigator: Saleh K Saleh, MD — Minia University
- Study coordinator: Saleh K Saleh, MD
- Email: salehkhairy@mu.edu.eg
- Phone: 01201765401
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Thyroid Nodule, Thyroid Dysfunction, Hypocalcemia, Thyroid Cancer, Postoperative Complications, Thyroidectomy, Postoperative hypocalcemia, Hypoparathyroidism