Four mouthwash options to help sockets heal after removal of an impacted lower wisdom tooth.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with a unilateral impacted mandibular third molar that requires bone removal are randomized to one of four postoperative rinses: Bone Bioactive Liquid (BBL), chlorhexidine digluconate (CHX), hyaluronic acid (HA), or warm saline mouth rinse (WSMR). The trial tracks extraction socket healing, postoperative complications, and patient-reported quality of life across follow-up visits. Standardized surgical technique and exclusion criteria (for example, recent antibiotics, active infections, immune compromise, or prior head/neck radiotherapy) are used to reduce confounding. Outcomes will compare healing rates, complication frequency, and patient comfort between the four groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar that is indicated for extraction with bone removal and the presence of an adjacent second molar.

Exclusion Criteria:

* Soft tissue impaction that will not need any bone removal.
* Presence of any acute oral infection including active Pericoronitis.
* Patients who have undergone radiotherapy in the head and neck region, chemotherapy or systemic long-term corticosteroid treatment.
* Patients receiving medications known to induce gingival hyperplasia; anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem).
* Patients who have taken systemic antibiotics less than 3 months prior to baseline.
* Presence of uncontrolled diabetes, severe nutritional deficiencies and endocrine disturbances.
* Presence of immune deficiency or any immune disease.
* Intravenous bisphosphonates or Oral bisphosphonate intake for more than 3 years.
* Smokers and alcoholics.
* Pregnant or lactating females.
* Hypersensitivity to one of the ingredients listed in any of the mouthwashes, especially chlorhexidine as reactions to this has been reported in the literature.

Where it's running

• University of Jordan hospital
  Amman, Jordan Recruiting

Study contacts

• Principal investigator: Ahmad Hamdan, Ph.D. in Periodontics — Faculty of Dentistry - University of Jordan
• Study coordinator: Ahmad Hamdan, Ph.D. in Periodontics
• Email: Ahmad.hamdan@ju.edu.jo
• Phone: + 962779099199

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.