Four mouthwash options to help sockets heal after removal of an impacted lower wisdom tooth.
A Randomized Controlled Trial on the Effect of Different Types of Mouthwash on the Healing of Extraction Sockets
This study will test whether four mouthwashes — Bone Bioactive Liquid, hyaluronic acid, chlorhexidine, or warm saline — help socket healing and improve quality of life after surgical removal of an impacted lower wisdom tooth in adults.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Jordan Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Amman) |
| Trial ID | NCT06587880 on ClinicalTrials.gov |
What this trial studies
Adults with a unilateral impacted mandibular third molar that requires bone removal are randomized to one of four postoperative rinses: Bone Bioactive Liquid (BBL), chlorhexidine digluconate (CHX), hyaluronic acid (HA), or warm saline mouth rinse (WSMR). The trial tracks extraction socket healing, postoperative complications, and patient-reported quality of life across follow-up visits. Standardized surgical technique and exclusion criteria (for example, recent antibiotics, active infections, immune compromise, or prior head/neck radiotherapy) are used to reduce confounding. Outcomes will compare healing rates, complication frequency, and patient comfort between the four groups.
Who should consider this trial
Good fit: Adults aged 18 or older with a unilateral impacted mandibular third molar requiring surgical extraction with bone removal and an adjacent second molar are the ideal candidates.
Not a fit: Patients with soft-tissue-only impactions not needing bone removal, active oral infection, recent antibiotic use, uncontrolled systemic disease, immune deficiencies, prior head/neck radiotherapy, or certain medications are excluded and unlikely to benefit from these interventions.
Why it matters
Potential benefit: If effective, one or more mouthwashes could speed socket healing, reduce postoperative complications, and improve comfort and quality of life after third molar extractions.
How similar studies have performed: Chlorhexidine and saline rinses are well established for reducing postoperative issues after extractions, hyaluronic acid has emerging supportive evidence, and Bone Bioactive Liquid is relatively novel for socket healing.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar that is indicated for extraction with bone removal and the presence of an adjacent second molar. Exclusion Criteria: * Soft tissue impaction that will not need any bone removal. * Presence of any acute oral infection including active Pericoronitis. * Patients who have undergone radiotherapy in the head and neck region, chemotherapy or systemic long-term corticosteroid treatment. * Patients receiving medications known to induce gingival hyperplasia; anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem). * Patients who have taken systemic antibiotics less than 3 months prior to baseline. * Presence of uncontrolled diabetes, severe nutritional deficiencies and endocrine disturbances. * Presence of immune deficiency or any immune disease. * Intravenous bisphosphonates or Oral bisphosphonate intake for more than 3 years. * Smokers and alcoholics. * Pregnant or lactating females. * Hypersensitivity to one of the ingredients listed in any of the mouthwashes, especially chlorhexidine as reactions to this has been reported in the literature.
Where this trial is running
Amman
- University of Jordan hospital — Amman, Jordan (Recruiting)
Study contacts
- Principal investigator: Ahmad Hamdan, Ph.D. in Periodontics — Faculty of Dentistry - University of Jordan
- Study coordinator: Ahmad Hamdan, Ph.D. in Periodontics
- Email: Ahmad.hamdan@ju.edu.jo
- Phone: + 962779099199
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.