Managing blood pressure and using dexamethasone during lung cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how intraoperative blood pressure management and the administration of dexamethasone affect outcomes for patients undergoing surgery for non-small cell lung cancer (NSCLC). It focuses on the relationship between blood pressure fluctuations during anesthesia and postoperative complications, as well as the potential benefits of dexamethasone in reducing inflammation and improving recovery. The study aims to determine if tailored blood pressure management can enhance both early and long-term survival rates in these patients. Participants will be monitored for various outcomes related to their surgery and recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged \>50 years but \<90 years.
* Diagnosed as resectable primary non-small cell lung cancer (stage IA-IIIA) and scheduled for radical surgery with an expected duration of \>2 hours.
* Agree to participate in this study and sign the informed consent.

Exclusion Criteria:

* Clinical examinations suggest non-resectable lung cancer or patients scheduled for a biopsy surgery.
* Recurrent or metastatic lung cancer.
* History of cancer or complicated with cancer in other organs.
* Long-term exposure to glucocorticoids or other immunosuppressant(s) due to autoimmune disease or organ transplantation.
* Uncontrolled hypertension (systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg); or requirement of vasopressors to maintain blood pressure.
* Persistent atrial fibrillation, or acute cardiovascular events (acute coronary syndrome, stroke, or congestive heart failure) within 3 months.
* Severe hepatic dysfunction (Child-Pugh C) or renal failure (requirement of renal replacement therapy).
* Any other circumstances considered unsuitable for study participation by attending physicians or investigators.

Where it's running

• Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, MD, PhD — Peking University First Hospital
• Study coordinator: Dong-Xin Wang, MD, PhD
• Email: wangdongxin@hotmail.com
• Phone: 86 (10) 83572784

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.