colorectal cancer Clinical Trials and Research
Also known as: colon cancer, rectal cancer, crc, bowel cancer, colorectal adenocarcinoma, large bowel cancer · ICD-10: C18-C20
Colorectal cancer is a type of cancer that begins in the colon or rectum. Clinical trial research is actively exploring new therapies, improved screening methods, and personalized treatment approaches to enhance patient outcomes. Find a Trial helps patients search for active studies in this area.
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Common questions about colorectal cancer clinical trials
Who can participate in colorectal cancer clinical trials?
Eligibility criteria vary by study but often include factors like cancer stage, previous treatments, and overall health. Researchers use these criteria to ensure patient safety and the study's scientific integrity, as seen on ClinicalTrials.gov.
What are the different phases of colorectal cancer clinical trials?
Clinical trials typically progress through phases 1, 2, and 3. Phase 1 studies test safety, Phase 2 evaluates effectiveness, and Phase 3 compares new treatments to existing ones, as detailed on ClinicalTrials.gov.
Do patients have to pay to participate in colorectal cancer clinical trials?
Often, study-related medical costs for experimental treatments are covered by the trial sponsor. However, standard medical care costs, like routine doctor visits, may still be billed to insurance, according to information on ClinicalTrials.gov.
What are some new research directions for colorectal cancer treatments?
Current research, supported by NIH RePORTER, focuses on immunotherapy, targeted therapies based on genetic markers, and advanced surgical techniques. Scientists are also investigating ways to prevent recurrence and improve quality of life for patients.
What types of interventions are commonly studied in colorectal cancer trials?
Studies often investigate new chemotherapy regimens, radiation therapies, and surgical procedures. Additionally, trials explore novel biological therapies, such as monoclonal antibodies, and immunotherapies designed to boost the body's own defenses, as seen on ClinicalTrials.gov.
Are there specific biomarkers relevant to colorectal cancer clinical trials?
Yes, biomarkers like KRAS, NRAS, BRAF, and MSI status are frequently studied to predict treatment response or guide personalized therapy. Research supported by NIH RePORTER aims to identify more precise markers for better patient stratification.
What might prevent someone from joining a colorectal cancer trial?
Common exclusion criteria can include certain co-existing medical conditions, specific prior treatments, or advanced disease that might make participation unsafe. Each study has unique requirements to ensure patient safety and data integrity, as outlined on ClinicalTrials.gov.
Are there clinical trials focused on preventing or screening for colorectal cancer?
Yes, many trials investigate new screening methods, like advanced imaging or blood tests, to detect colorectal cancer earlier. Others explore lifestyle interventions or medications that might reduce the risk of developing the disease, as shown on ClinicalTrials.gov.
How to find a colorectal cancer trial that fits you
- Describe your colorectal cancer situation in detail — stage if applicable, prior treatments, age, and other relevant conditions.
- Use the location filter (worldwide, US, US & Canada, Europe) to narrow to trials near you.
- Review each trial's eligibility criteria carefully. Save 2–5 candidates with their NCT numbers.
- Discuss with your treating clinician before contacting the research site.
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