Evaluating fluid therapy for recovery after head and neck cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess the effectiveness of goal-directed fluid therapy (GDFT) in improving postoperative recovery for patients undergoing head and neck cancer surgery. Participants will be randomly assigned to receive either GDFT or standard fluid therapy during their surgery. The study will monitor and compare the occurrence of postoperative complications and the length of hospital stays between the two groups. Continuous follow-up will be conducted during hospitalization and after discharge to gather comprehensive data on recovery outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (Age≥18)
* Scheduled to undergo head and neck cancer surgery (including nasopharyngeal carcinoma, laryngocarcinoma, hypopharyngeal carcinoma, and other head and neck malignancies, but not thyroid cancer) with an expected duration of 2 hours or longer
* Agree to receive invasive artery blood pressure monitoring

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) classification\>Ⅳ
* Palliative surgery was performed for the terminal tumors
* Microlaryngoscopic laser surgery or endoscopic surgery
* Underwent major thoracic or abdominal surgery within 30 days
* Regular renal replacement therapy is required
* NYHA grade\>3 or ejection fraction \<30%
* Lung disease does not tolerate the tidal volume by 8 ml/kg
* Atrial fibrillation
* Unable to give informed consent
* pregnant or lactating woman
* Emergency surgery

Where it's running

• Beijing tongren Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Guyan Wang — Beijing Tongren Hospital, CMU
• Study coordinator: Xuan Liang, master
• Email: doctor_xuan@hotmail.com
• Phone: +8613810261846

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.