Axillary Web Syndrome after Breast Cancer Surgery: Incidence, Risk Factors, and Outcomes
Official title: A Prospective Multicenter Cohort Study on the Incidence, Risk Factors, and Postoperative Functional Outcomes of Axillary Web Syndrome After Breast Cancer Surgery
Run by Antalya City Hospital · NCT07780240 · Data updated 2026-11-12
This study tests how often AWS occurs after breast cancer surgery and what factors make it more likely, using a forward-looking approach in women undergoing SLNB or ALND.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | Women only |
| Enrollment | 250 (estimated) |
| Sponsor | Antalya City Hospital Academic / other |
| Locations | 2 sites (Istanbul, BAGCILAR and 1 other locations) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | October 2027 |
| Study ends | October 2027 |
| Registry record updated | August 21, 2026 |
| Trial ID | NCT07780240 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18 or older with breast cancer undergoing SLNB or ALND who can consent and are able to comply with follow-up.
✕Probably not a fit
Patients who do not develop AWS or who have no meaningful changes in shoulder function may not benefit from any intervention in this observational design.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, multicenter observational cohort study of women undergoing breast cancer surgery with axillary staging. Participants are followed before surgery and at 2, 4, and 8 weeks, and at 3 and 6 months after surgery to document the appearance, course, and potential factors related to axillary web syndrome. Data are collected using standardized assessments to determine incidence, timing, clinical features, and associations with lymphedema and functional outcomes. There is no treatment assignment or control group within the study; comparisons are made within the cohort between those who develop AWS and those who do not.
Why it matters
Potential benefit: If successful, the study could clarify when AWS tends to occur and which patients are at higher risk, informing monitoring and early management.
How similar studies have gone: Previous data are mainly retrospective; this prospective approach aims to provide clearer incidence and risk factors, with some prior studies suggesting AWS is relatively common.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Diagnosis of breast cancer with planned surgical treatment * Axillary staging performed by sentinel lymph node biopsy or axillary lymph node dissection * Written informed consent provided Exclusion Criteria: * Preoperative restriction of shoulder range of motion * History of neuromuscular disease affecting the upper extremity * Metastatic disease * Anticipated inability to comply with the follow-up protocol
Where it's running
-
Bagcilar Training and Research Hospital
Istanbul, Bagcilar, Turkey (Türkiye) Recruiting -
Antalya City Hospital
Antalya, Kepez, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Mehmet Olcum, Md
- Email: mehmetolcum@hotmail.com
- Phone: +905388101828
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.