Pre-surgery nutrition and inflammation markers and early recovery after sleeve gastrectomy
Official title: The Relationship Between Preoperative Nutritional and Inflammatory Markers and Early Postoperative Clinical Outcomes in Patients Undergoing Bariatric Surgery
Run by Istinye University · NCT07007494 · Data updated 2026-11-12
This project tests whether pre-surgery nutrition and inflammation lab markers (PNI, HALP, NLR, CRP) can help predict early recovery, complications, and hospital stay length in adults having elective laparoscopic sleeve gastrectomy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 86 (estimated) |
| Sponsor | Istinye University Academic / other |
| Locations | 1 site (Istanbul, Merkez Mahallesi) |
| Status | Recruiting |
| Started | June 2, 2025 |
| Main results expected | August 2, 2025 |
| Study ends | August 15, 2025 |
| Registry record updated | July 16, 2025 |
| Trial ID | NCT07007494 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with BMI ≥35 kg/m² who are scheduled for elective laparoscopic sleeve gastrectomy and have complete preoperative lab results are ideal candidates.
✕Probably not a fit
Patients with severe liver or kidney failure, active infection, hematologic malignancies, recent immunosuppression, or those requiring ICU within 72 hours are unlikely to benefit from these marker-based predictions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study enrolling adults with BMI ≥35 who are scheduled for elective laparoscopic sleeve gastrectomy at Istinye University in Istanbul. Investigators will collect preoperative laboratory data to calculate PNI, HALP score, NLR, and CRP and then track early postoperative outcomes including time to oral intake, mobilization, complications, and length of hospital stay. Key exclusions include severe hepatic or renal dysfunction, active infection, history of immunosuppressive therapy or hematologic malignancy, perioperative albumin or blood product use, and need for ICU admission within the first 72 hours. Associations between preoperative marker levels and early clinical outcomes will be analyzed using regression models and predictive performance metrics.
Why it matters
Potential benefit: If successful, this could help clinicians identify patients at higher risk for delayed recovery or complications before surgery so they can tailor perioperative care.
How similar studies have gone: Similar biomarker approaches (PNI, NLR, CRP) have shown associations with outcomes in other surgical populations, but their predictive value specifically for sleeve gastrectomy is not yet well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 65 years * Body mass index (BMI) ≥ 35 kg/m² * Scheduled for elective laparoscopic sleeve gastrectomy * Availability of complete preoperative laboratory test results * Signed informed consent Exclusion Criteria: * Severe hepatic or renal dysfunction * Presence of active infection * History of immunosuppressive therapy or hematologic malignancy * Need for intensive care unit (ICU) admission within the first 72 hours postoperatively * Preoperative administration of albumin or blood products
Where it's running
-
Istinye Üniversity
Istanbul, Merkez Mahallesi, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: ilke dolgun
- Email: ilkeser2004@gmail.com
- Phone: +905555485632
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.