Pre-surgery nutrition and inflammation markers and early recovery after sleeve gastrectomy
The Relationship Between Preoperative Nutritional and Inflammatory Markers and Early Postoperative Clinical Outcomes in Patients Undergoing Bariatric Surgery
This project tests whether pre-surgery nutrition and inflammation lab markers (PNI, HALP, NLR, CRP) can help predict early recovery, complications, and hospital stay length in adults having elective laparoscopic sleeve gastrectomy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 86 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Istinye University Academic / other |
| Locations | 1 site (Istanbul, Merkez Mahallesi) |
| Trial ID | NCT07007494 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational study enrolling adults with BMI ≥35 who are scheduled for elective laparoscopic sleeve gastrectomy at Istinye University in Istanbul. Investigators will collect preoperative laboratory data to calculate PNI, HALP score, NLR, and CRP and then track early postoperative outcomes including time to oral intake, mobilization, complications, and length of hospital stay. Key exclusions include severe hepatic or renal dysfunction, active infection, history of immunosuppressive therapy or hematologic malignancy, perioperative albumin or blood product use, and need for ICU admission within the first 72 hours. Associations between preoperative marker levels and early clinical outcomes will be analyzed using regression models and predictive performance metrics.
Who should consider this trial
Good fit: Adults aged 18–65 with BMI ≥35 kg/m² who are scheduled for elective laparoscopic sleeve gastrectomy and have complete preoperative lab results are ideal candidates.
Not a fit: Patients with severe liver or kidney failure, active infection, hematologic malignancies, recent immunosuppression, or those requiring ICU within 72 hours are unlikely to benefit from these marker-based predictions.
Why it matters
Potential benefit: If successful, this could help clinicians identify patients at higher risk for delayed recovery or complications before surgery so they can tailor perioperative care.
How similar studies have performed: Similar biomarker approaches (PNI, NLR, CRP) have shown associations with outcomes in other surgical populations, but their predictive value specifically for sleeve gastrectomy is not yet well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 65 years * Body mass index (BMI) ≥ 35 kg/m² * Scheduled for elective laparoscopic sleeve gastrectomy * Availability of complete preoperative laboratory test results * Signed informed consent Exclusion Criteria: * Severe hepatic or renal dysfunction * Presence of active infection * History of immunosuppressive therapy or hematologic malignancy * Need for intensive care unit (ICU) admission within the first 72 hours postoperatively * Preoperative administration of albumin or blood products
Where this trial is running
Istanbul, Merkez Mahallesi
- Istinye Üniversity — Istanbul, Merkez Mahallesi, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: ilke dolgun
- Email: ilkeser2004@gmail.com
- Phone: +905555485632
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.