Understanding biomarkers in patients undergoing high-risk surgery
Biomarkers to Guide Perioperative Management and Improve Outcome in High-risk Surgery
St. Antonius Hospital · NCT05199025
This study is trying to find out if certain blood markers can help predict complications after high-risk surgeries to improve patient care and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Antonius Hospital (other) |
| Locations | 2 sites (Breda, North Brabant and 1 other locations) |
| Trial ID | NCT05199025 on ClinicalTrials.gov |
What this trial studies
This observational study aims to analyze the perioperative biomarker responses in patients undergoing high-risk surgeries, such as cardiac, colorectal, vascular, and lung procedures. By collecting blood samples and clinical data from 4,819 patients, the study seeks to identify biomarkers that can predict postoperative complications and improve risk stratification. The goal is to develop a predictive model that can guide treatment decisions and enhance patient outcomes following surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are adults undergoing elective high-risk surgeries, including cardiac, gastrointestinal, vascular, or lung procedures.
Not a fit: Patients under 18 years old, pregnant individuals, those requiring emergent surgery, or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prediction and management of postoperative complications, enhancing patient safety and quality of life.
How similar studies have performed: Other studies have shown promise in using biomarkers for predicting postoperative complications, indicating that this approach has potential based on previous findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cardiac surgery (isolated coronary artery bypass grafting or combined with single valve surgery, isolated single valve surgery) * Gastrointestinal surgery (colorectal, pancreatic, gastric surgery). * Vascular surgery (open and endovascular aortic surgery, peripheral vascular surgery) * Lung surgery (pneumonectomy,(bi)(sleeve)lobectomy or segmentectomy) Exclusion Criteria: * Age \< 18 years * Pregnancy * Emergent surgery * No informed consent
Where this trial is running
Breda, North Brabant and 1 other locations
- Amphia Hospital — Breda, North Brabant, Netherlands (RECRUITING)
- St Antonius Hospital — Nieuwegein, Utrecht, Netherlands (RECRUITING)
Study contacts
- Study coordinator: Peter Noordzij
- Email: p.noordzij@antoniusziekenhuis.nl
- Phone: 0031883203000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Postoperative Complications, Quality of Life, Death