Condition

Wound Healing clinical trials and research

• 21Clinical trials
• 130NIH research projects
• 2New in 30 days
• 14Countries

Newest Wound Healing clinical trials

All recruiting trials (21)

• Lactoferrin Gel for Healing and Implant Stability in Immediate Mandibular Molars

  A 4% bovine lactoferrin nanohydrogel is being tested to see if it helps soft tissue and bone heal better and improve implant stability after immediate mandibular molar implants.

  Recruiting Phase 2/3 Future University in Egypt · Cairo, Cairo Governorate · NCT07889674

• Curcumin topical spray for healing after a first molar extraction

  This study tests whether a curcumin spray applied to the extraction site helps healing and reduces pain compared with chlorhexidine spray or standard care in healthy adults undergoing a first molar extraction.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07874789

• Calcaneal Bone Marrow Cells in Foot/Ankle Surgery Patients

  This observational study tests whether routine preoperative blood tests relate to the quality and behavior of mesenchymal stem cells from calcaneal bone marrow in adults undergoing foot or ankle surgery.

  Recruiting Universidade Sao Francisco · Bragança Paulista, São Paulo · NCT07802106

• Obesity and normal-weight healing after gum graft surgery using collagen plug or PRF

  This study tests whether healing after a gum graft differs by weight class (obese vs. normal weight) and compares platelet-rich fibrin clot to the standard collagen plug.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07756112

• Early Wound Healing and Outcomes of Regenerative Periodontal Surgery

  This study looks to see if healing in the first 1–2 weeks after periodontal regenerative surgery can predict how well the treatment works at 12 months in people with advanced periodontitis.

  Recruiting University of Roma La Sapienza · Rome, Rome · NCT07683962

• Ozoaqua scar care after open abdominal surgery compared with standard care

  This study tests if adding Ozoaqua products after open abdominal surgery improves the scar quality at 3 months compared with usual care.

  Recruiting at 2 sites Laboratorios Ozoaqua · Pamplona, Navarre and 1 other locations · NCT07678372

• Effects of different CO2 and 1565 nm fractional laser doses on forearm skin healing

  This test looks at how different energy settings of CO2 and 1565 nm fractional lasers change skin damage and repair on the inner forearms of healthy Chinese women aged 18–60 with Fitzpatrick skin types III–V.

  Recruiting ChinaNorm · Shanghai, Shanghai Municipality · NCT07561242

• Can infrared thermography help predict how skin wounds heal after surgery?

  This study tests if a harmless infrared camera can spot early signs of wound problems after skin surgery so clinicians can act sooner.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams Brabant · NCT07524062

• Cold (non-thermal) plasma to improve healing and reduce complications after thyroid removal

  This will test whether applying helium-based non-thermal (cold) plasma during total thyroidectomy helps wounds heal faster and reduces pain, inflammation, and infections in adults having their thyroid removed.

  Recruiting National Institute of Nuclear Research - Mexico · Ocoyoacac, State of Mexico · NCT07382973

• Nano-biofusion gingival gel to improve palate wound healing after gum grafts

  We will try a nano-biofusion gingival gel (NBF) to see if it speeds healing, reduces pain, and lowers inflammation for adults who have a palatal donor wound after soft tissue gum graft surgery.

  Recruiting King Abdullah University Hospital · Irbid, Irbid Governorate · NCT07330154

• Monitoring blood markers during DIEP flap breast reconstruction

  We will see if measuring inflammation and oxidative stress markers in blood before and during the first 72 hours after DIEP flap reconstruction helps map recovery patterns for women having immediate breast reconstruction after mastectomy.

  Recruiting Hubei Cancer Hospital · Wuhan, Hubei · NCT07263347

• HealiAid collagen wound dressing for people having breast tumor surgery

  This will test a collagen wound dressing called HealiAid to see if it is safe and well tolerated in people having surgery to remove breast tumors.

  Recruiting at 3 sites Maxigen Biotech Inc. · New Taipei City, Taiwan and 2 other locations · NCT07209020

• Lower leg skin grafts after tumour removal: does negative pressure dressings help or not?

  This trial tests whether negative pressure wound therapy over split-thickness skin grafts on the lower leg reduces infection compared with traditional dressings in adults after skin tumour removal.

  Recruiting Region Skane · Malmö · NCT07040683

• St. John's Wort oil for cesarean scar healing and pain

  This test tries applying St. John's Wort (Hypericum perforatum) oil to the cesarean scar to see if it speeds healing and reduces pain for women after their first C-section.

  Recruiting Sakarya University · Sakarya · NCT07012278

• OROXID® mouthwash to support healing after oral surgery

  This trial will test whether OROXID® mouthwash helps wounds heal faster and reduces inflammation after tooth extraction or apicoectomy in adults.

  Recruiting ENIKAM d.o.o. · Muljava, Municipality of Ivančna Gorica · NCT06987253

• Using Timolol Solution to Heal Surgical Wounds Faster

  This study is testing if a special eye drop solution can help speed up the healing of surgical wounds on the legs after Mohs surgery compared to regular care.

  Recruiting Phase 1 Icahn School of Medicine at Mount Sinai · New York, New York · NCT06941467

• Silk bioprotein wound dressing for double‑incision mastectomy

  This project will test whether a silk bioprotein dressing reduces adhesive‑related skin injuries and other wound problems compared with Dermabond/Prineo in adults having double‑incision mastectomy for gender‑affirming surgery.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06921148

• Comparing wound healing methods in breast reduction surgery

  This study is testing if a special type of wound treatment helps women heal better after breast reduction surgery compared to regular bandages.

  Recruiting Medstar Health Research Institute · Washington D.C., District of Columbia · NCT06725459

• Wound care after pilonidal sinus surgery

  This study tests if a special wound treatment helps people heal better and feel happier after surgery for pilonidal sinus disease compared to regular wound care.

  Recruiting at 10 sites Royal College of Surgeons, Ireland · Castlebar and 9 other locations · NCT06647290

• Jaw ridge changes after tooth removal and ridge preservation

  We will see if a socket that widens right after a tooth is removed or stays the same changes ridge width and height four months later in adults having a single extraction with bone graft and a resorbable membrane.

  Recruiting Marquette University · Milwaukee, Wisconsin · NCT06624982

• Evaluating SLI-F06 for improving scar appearance in healthy volunteers

  This study is testing a new treatment called SLI-F06 to see if it can improve the appearance of scars in healthy volunteers aged 18 to 65.

  Recruiting at 2 sites Phase 2 Scarless Laboratories, Inc. · Encinitas, California and 1 other locations · NCT05501327

NIH-funded research (newest 40 of 130)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immunomodulatory therapy to speed up healing after oral cavity injuries in kids

  A new approach using a drug called FTY720 aims to improve healing and reduce pain after oral injuries or palate surgery in children.

  NIH research Old Dominion University · Norfolk, United States · NIH-11472773

• Aiming to slow dangerous lung inflammation to help fight bacterial infections like tuberculosis

  A patient-facing program tests whether stopping a specific inflammatory cell (Spp1+ macrophages) from overreacting can help control tuberculosis and possibly improve outcomes in other inflammatory diseases.

  NIH research Washington University · Saint Louis, United States · NIH-11436386

• Engineered protein materials to study wound healing and blood vessels

  A researcher team at the University of New England is studying how the environment around a protein changes its behavior to better understand wound healing and blood vessel formation.

  NIH research University of New England · Biddeford, United States · NIH-11429158

• Understanding how healing tissue uses tiny messengers and scaffolds to repair wounds

  A study to learn how cells talk to each other and how tiny vesicles and the extracellular matrix help skin wounds heal better.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11425396

• Hormone signals and sex differences in how wounds heal

  This grant explores how male- and female-specific hormones affect wound healing and scarring, with the goal of improving treatments for people who heal poorly.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11401209

• Therapeutic extracellular vesicles to boost skin wound healing

  A research grant is exploring how tiny cell messengers called extracellular vesicles can be engineered to improve skin wound repair in injury models.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11396458

• Understanding how RNA guides wound healing and regeneration in adults

  This NIH grant explores how RNA-related signals coordinate healing and tissue repair in adults who have wounds or injuries.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11393845

• How sex hormones like testosterone and estrogen change wound healing and scarring

  This project looks at how testosterone and estrogen change the way wounds heal and form scars so future care can be better matched to men and women.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11393563

• Multicomponent hydrogels to promote hair growth and scarless wound healing

  A researcher at UPenn is testing a special gel to help human-like wounds heal with hair follicles and fewer scars.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11385362

• Role of a skin-healing gene locus in speeding wound repair

  A study at UC Irvine will explore how a specific genetic region near the FAAH gene may make skin wounds heal faster with less scarring, with potential ideas for new therapies.

  NIH research University of California-Irvine · Irvine, United States · NIH-11382807

• Understanding how mechanical forces affect diabetic wound healing

  This NIH grant supports research to learn how physical forces influence healing of diabetes-related skin wounds, with the goal of improving outcomes for people who have diabetes.

  NIH research Stanford University · Stanford, United States · NIH-11380664

• Langerhans Cells and Nociception in Burn Wounds

  Researchers are studying how nerve signals and a skin immune cell type called Langerhans cells interact to influence healing and itch/pain after burns, using mouse models.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11377584

• Predicting obesity-related diabetes and wound healing with math models

  A math-based model is being built to better understand how obesity drives type 2 diabetes and slow wound healing in adults.

  NIH research Rochester Institute of Technology · Rochester, United States · NIH-11377524

• Neural signals in surgical wound healing and how regional anesthesia changes them

  Researchers are studying how nerve signals and the immune system interact after surgery and how regional anesthesia might improve healing.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11377380

• Biomaterial Models of Ancestral Contributions to Wound Healing

  Researchers are studying how ancestry may influence skin wound healing using lab models to uncover clues for more personalized therapies.

  NIH research Univ of Maryland, College Park · College Park, United States · NIH-11376545

• CD74 and Mucosal Wound Healing

  A study at the University of Florida looks at how the CD74 protein helps mucosal healing after injuries like surgery or infection, aiming to find ways to improve recovery.

  NIH research University of Florida · Gainesville, United States · NIH-11370161

• New insights into how corneal nerves support healing to help neurotrophic keratopathy patients

  Aimed at understanding how corneal nerves and their supporting Schwann cells keep the corneal surface healthy, with the goal of developing topical therapies for neurotrophic keratopathy.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11369632

• Why skin and mouth wounds heal slowly in diabetes

  This project tests a targeted drug (MM-102) to help adults with type 1 or type 2 diabetes heal skin and oral wounds more normally.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11367549

• Exosomes and skin healing in diabetes

  A study exploring how tiny vesicles from skin cells communicate with immune cells to improve healing of diabetic wounds.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11360166

• Neutrophil diversity and flexibility in healing burn injuries

  A study exploring how different neutrophil types behave during burn wound healing and whether blood neutrophils can signal how well a wound will recover.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11357664

• Immunomodulatory nanofiber gel to help chronic wounds heal faster

  A research team is testing a tiny, advanced gel made of nanofibers and peptides to steer immune cells toward healing so chronic wounds can close sooner.

  NIH research Terasaki Institute for Biomedical Innovation · Woodland Hills, UNITED STATES · NIH-11347242

• Opioids may help heal chemical-wound skin injuries in humans

  A small NIH-funded project will test whether topical opioids can speed up healing after skin damage caused by chemical vesicants like sulfur mustard and nitrogen mustard.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11336772

• PEDF-enriched urine-derived stem cell sheets for corneal healing after sulfur mustard injury

  A new therapy using a patient’s own urine-derived stem cells engineered to release PEDF aims to heal corneal wounds caused by sulfur mustard exposure.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11335528

• How salamanders rebuild organs fast to guide human healing

  Researchers study how salamanders rapidly regrow limbs and organs to find ways to help people heal better after injuries.

  NIH research Stanford University · Stanford, United States · NIH-11333324

• Nanoparticles that protect healing proteins for chronic leg, foot, and pressure wounds

  This project develops nanoparticles that protect growth-factor proteins to help older adults with venous leg ulcers, diabetic foot ulcers, or pressure sores heal better.

  NIH research University of South Florida · Tampa, United States · NIH-11326716

• Anal transition zone cells that repair the colon lining

  Seeing if special cells near the anus can help heal the damaged colon lining for people with inflammatory bowel disease.

  NIH research University of Chicago · Chicago, United States · NIH-11325804

• Helping tissues and organs heal better after injury

  This work aims to boost adult tissue cells' ability to renew themselves so wounds and organ injuries heal more fully with less scarring.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11325388

• Hydrogels that help wounds heal by guiding your own cells

  Researchers are creating soft, sponge-like gel materials that guide the body's own cells into injured tissue to help wounds close and repair more effectively.

  NIH research Purdue University · West Lafayette, United States · NIH-11319869

• NaNOCure: a nanoparticle ointment to prevent infection and speed healing in burn wounds

  A new topical nanoparticle ointment called NaNOCure is being developed to prevent infection, reduce inflammation, and speed healing for burn wounds at home.

  NIH research Nobiotics LLC · Raleigh, United States · NIH-11309966

• Throat bacteria and healing after voice-box injuries

  This project looks at how microbes living on the voice box affect healing after throat injuries to help people with voice problems recover better.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11306061

• Using nanoparticles to improve healing of chronic wounds in older adults

  This study is looking at tiny particles that can help deliver healing substances to stubborn wounds, especially for older adults dealing with issues like diabetic foot ulcers and pressure sores, to make it easier for them to heal.

  NIH research University of South Florida · Tampa, United States · NIH-11301475

• Self-powered bandage to speed skin wound healing

  A lightweight, disposable bandage that generates tiny electric pulses to help people with slow-healing or chronic skin wounds heal faster.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11292886

• High-frequency, low-amplitude vibration device to speed healing of diabetic foot ulcers

  A handheld vibration device is being used to help people with diabetes heal stage 2 foot ulcers faster and feel better sooner.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11291877

• Using the protein PIP to help heal corneal scarring

  This project uses a naturally occurring protein called PIP to try to reduce scarring and help the cornea heal in people with corneal injuries or disease.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11285218

• STAT4-driven immune problems and poor wound healing in disabling pansclerotic morphea

  The team will try blocking overactive STAT4/JAK signaling to reduce inflammation and help wound healing for children with disabling pansclerotic morphea.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11267975

• Immunomodulation and smart biomaterials to prevent and heal wound infections

  A NIH grant is funding research to develop advanced biomaterials and therapies that prevent surgical site infections and promote healing in hard-to-heal wounds, especially in people with diabetes.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11260059

• How a natural protein (MFG-E8) may help the liver heal after cell loss

  This work looks at whether the protein MFG-E8 helps the liver recover after liver-cell death, which could help people with acute or chronic liver injury.

  NIH research Jesse Brown VA Medical Center · Chicago, United States · NIH-11213919

• How Langerhans Cells and Nerves Affect Healing and Pain After Burns

  This project explores how certain immune cells and nerve endings work together to influence wound healing, itching, and pain after a burn injury.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11182723

• Blood protein markers to predict healing of diabetic foot wounds

  This project looks for patterns in blood proteins that can predict how well foot ulcers heal in people with diabetes.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11173857

• How immune cell metabolism helps wounds heal

  Researchers are seeing whether changing the metabolism of immune cells can help wounds heal better for people with chronic wounds or inflammatory diseases.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11172658

Related topics

Quick answers

How many Wound Healing clinical trials are recruiting right now?

21, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (6 trials), Turkey (Türkiye) (2 trials), China (2 trials), Egypt (1 trial), Mexico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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