Condition

Gastroparesis clinical trials and research

• 26Clinical trials
• 33NIH research projects
• 10Countries

Newest Gastroparesis clinical trials

All recruiting trials (26)

• Gastric-focused ultrasound to see if it changes stomach activity and symptoms

  This study tests whether noninvasive stomach-focused ultrasound can alter post-meal stomach electrical activity and symptoms in adults with gastroparesis or delayed gastric emptying, using a sham control in a crossover design.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07851727

• Gastric emptying and feeding tolerance in ICU patients by vasopressor dose

  This study tests whether vasopressor dose affects how well stomach contents empty during tube feeding in critically ill patients.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul · NCT07802379

• Virtual poetry workshops to boost well-being for people with digestive symptoms

  This study tests whether participating in online poetry workshops can improve emotional well-being for adults with chronic digestive symptoms and anxiety or depression.

  Recruiting Ohio State University · Columbus, Ohio · NCT07717541

• Risk prediction for gastric retention during sedated gastroscopy

  This study will test a simple grading system and prediction model to see if clinicians can identify which adults are likely to have significant stomach contents before sedated gastroscopy.

  Recruiting at 2 sites Zhejiang University · Hangzhou, Zhejiang and 2 other locations · NCT07104214

• Prokinetics and Body Surface Gastric Mapping in Dyspeptic Patients

  This study tests whether using Body Surface Gastric Mapping can help predict which medications will help people with gastroparesis or functional dyspepsia see improvement.

  Recruiting at 2 sites University of Auckland, New Zealand · Philadelphia, Pennsylvania and 2 other locations · NCT06854120

• Using Growth Hormone to Treat Gastroparesis

  This study is testing if Growth Hormone can help people with gastroparesis feel better when other treatments haven't worked.

  Recruiting at 2 sites Early Phase 1 Mayo Clinic · Phoenix, Arizona and 1 other locations · NCT06803589

• Implanting a gastric pacemaker to treat gastroparesis

  This study is testing whether a gastric pacemaker can help people with severe gastroparesis who haven't found relief from other treatments by improving their stomach function and reducing symptoms like nausea and bloating.

  Recruiting Evangelic Hospital Kalk Cologne · Cologne, North Rhine-Westphalia · NCT06661668

• Exploring the effects of ear acupuncture on delayed gastric emptying after abdominal surgery

  This study is testing whether ear acupuncture can help people aged 40-70 who have had certain abdominal surgeries feel better and manage symptoms like nausea caused by delayed gastric emptying.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06580197

• Enhanced programming stimulation for gastroparesis treatment

  This study is testing if a new way of programming a device for treating gastroparesis can help people feel better and improve their quality of life faster.

  Recruiting at 6 sites Enterra Medical, Inc. · Tampa, Florida and 5 other locations · NCT06560307

• Improving nutrition in critically ill patients with gastrointestinal issues

  This study tests if combining two types of nutrition methods can help critically ill patients with gut issues get the right amount of food they need to recover.

  Recruiting Romanian Society for Enteral and Parenteral Nutrition · Bucharest · NCT06510348

• Using Body Surface Gastric Mapping to Improve G-POEM Outcomes

  This study is testing if a new mapping technique can help doctors find the right patients with gastroparesis who would benefit from a specific procedure called G-POEM.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06493032

• Comparing G-POEM and PEG-J treatments for gastroparesis

  This study is testing whether a new procedure called G-POEM or a feeding tube method called PEG-J can help people with stubborn gastroparesis feel better.

  Recruiting Maastricht University Medical Center · Maastricht, Zuid-Limburg · NCT06372132

• Assessing gastric functions in patients with diabetes

  This study looks at how diabetes affects stomach function in people with Type 1 and Type 2 diabetes to see if there are any problems and how these issues relate to their overall health.

  Recruiting at 5 sites Institute for Clinical and Experimental Medicine · Ostrava and 4 other locations · NCT06068114

• National registry for children and young adults with gastroparesis

  This study is creating a national registry to track the symptoms and experiences of children and young adults with gastroparesis to better understand the condition and how it affects their lives.

  Recruiting at 6 sites Johns Hopkins Bloomberg School of Public Health · Boston, Massachusetts and 5 other locations · NCT05981300

• Evaluating Enterra Device Programming for Gastroparesis Relief During Sleep

  This study is testing different ways to program the Enterra® device at night to see if it helps people with gastroparesis feel better while they sleep.

  Recruiting at 2 sites Enterra Medical, Inc. · Louisville, Kentucky and 1 other locations · NCT05980455

• Evaluating the use of endoscopic myotomy for gastrointestinal motility disorders

  This study is testing how well a procedure called endoscopic myotomy works for people with different gastrointestinal motility disorders like achalasia and gastroparesis over several years.

  Recruiting AdventHealth · Orlando, Florida · NCT05905016

• Evaluating gastric activity in children with gastrointestinal symptoms

  This study tests how stomach activity in children with tummy problems compares to healthy kids to see if a new device can help understand their symptoms better.

  Recruiting at 5 sites Children's Hospital of Philadelphia · San Diego, California and 4 other locations · NCT05880199

• Registry for patients with gastroparesis and functional dyspepsia

  This study is trying to learn more about people with gastroparesis and functional dyspepsia by collecting information on their symptoms and experiences over 48 weeks.

  Recruiting at 6 sites Johns Hopkins Bloomberg School of Public Health · Scottsdale, Arizona and 5 other locations · NCT05846802

• Examining gastric motility in patients with eosinophilic gastritis

  This study is trying to see if people with eosinophilic gastritis have problems with how their stomach moves and digests food.

  Recruiting at 3 sites Children's Hospital Medical Center, Cincinnati · Chicago, Illinois and 2 other locations · NCT05229432

• Using domperidone to help young people with severe stomach issues

  This study is testing if the medication domperidone can help young people aged 12 to 21 with severe stomach problems that haven't improved with other treatments.

  Recruiting Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT04699591

• Checking pyloric sphincter function in people with gastroparesis symptoms

  We will test whether EndoFLIP, a water‑load satiety test, and a gastric electrical test (Gastric Alimetry) can find pyloric sphincter abnormalities in adults with gastroparesis symptoms compared with people without symptoms.

  Recruiting at 5 sites Johns Hopkins Bloomberg School of Public Health · Scottsdale, Arizona and 4 other locations · NCT04661215

• Registry for gastrointestinal motility disorders at Indiana University

  This study is creating a detailed list of patients with gastrointestinal motility disorders to help doctors better understand and treat these conditions.

  Recruiting Indiana University · Indianapolis, Indiana · NCT04506593

• Endoscopic procedure for treating gastroparesis

  This study is testing a new endoscopic procedure called G-POEM to see if it can help people with gastroparesis feel better and manage their symptoms.

  Recruiting Indiana University · Indianapolis, Indiana · NCT04434781

• Using IVIG to treat gastrointestinal autoimmune neuropathy

  This study is testing whether intravenous immunoglobulin (IVIG) can help people with autoimmune gastrointestinal issues feel better when other treatments haven't worked.

  Recruiting University of Louisville · Louisville, Kentucky · NCT04208828

• Longitudinal database for patients with gastroparesis symptoms

  This study is tracking patients with gastroparesis symptoms over time to see how their health and quality of life change, regardless of the treatments they receive.

  Recruiting University of Louisville · Louisville, Kentucky · NCT03876288

• Registry for understanding gastroparesis and related motility disorders

  This study is trying to understand the causes of gastroparesis and related digestive issues by collecting samples and information from patients having surgery for these conditions.

  Recruiting Indiana University · Indianapolis, Indiana · NCT02165059

NIH-funded research (33)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• New England Gastroparesis Consortium: Neurobiology of Gastroparesis

  A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11583186

• Pediatric and Young Adult Gastroparesis Registry and Disease Course

  This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.

  NIH research Texas Tech University Health Sciences Center at El Paso · El Paso, United States · NIH-11575566

• Pediatric gastroparesis: building a nationwide patient registry

  This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11567122

• Gut-resident macrophages and gastric function in gastroparesis

  A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.

  NIH research University of Nevada Reno · Reno, United States · NIH-11430037

• Gastric electrical stimulation for stomach pain in gastroparesis

  A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.

  NIH research University of Louisville · Louisville, United States · NIH-11416260

• Peptide therapies for gastroparesis in diabetes

  A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.

  NIH research Cga Therapeuticals Incorporated · San Diego, United States · NIH-11410020

• Prucalopride for gastroparesis in adults: a multi-site trial

  A multicenter study tests a medicine called prucalopride to help adults with gastroparesis feel better and have fewer stomach symptoms.

  NIH research Texas Tech University Health Sciences Center at El Paso · El Paso, United States · NIH-11393898

• Gastroparesis: understanding causes and improving treatments for this stomach-emptying disorder

  A national research effort at University of Louisville is studying why gastroparesis happens and how to treat it, with patients experiencing symptoms like nausea, vomiting, and abdominal pain in mind.

  NIH research University of Louisville · Louisville, United States · NIH-11386523

• Temple University Gastroparesis Clinical Center: Advancing Understanding and Care

  A patient-centered grant from NIH supports Temple University to enroll people with gastroparesis in ongoing studies to better understand causes and improve treatments.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11386478

• Advancing Pediatric Gastroparesis Care and Understanding

  A long-running NIH grant aims to improve how gastroparesis affects children and young people, by building better patient-reported measures and understanding what makes the disease worse.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11384700

• Exploring subtypes of gastroparesis and related symptoms using physiological tests

  This grant supports research to better classify gastroparesis and gastroparesis-like symptoms by physiological testing to guide personalized care.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11384672

• New England Gastroparesis Consortium: Neurobiology of Gastroparesis

  A multi-site project to understand the brain and gut factors behind gastroparesis and to test a potential cognitive behavioral therapy to help people living with this condition.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11384657

• Understanding and Treating Gastroparesis: New Registry, Ongoing Studies, and a Possible Targeted Therapy

  A Mayo Clinic team is proposing to improve diagnosis and treatment for gastroparesis and related conditions by finishing current studies, creating a larger patient registry, and exploring a potential therapy that targets immune activity in the stomach.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11384498

• Gastroparesis data center continues to support kids and adults with gastroparesis

  A national research program at Johns Hopkins will keep gathering and sharing data and biospecimens from adults and children with gastroparesis to improve diagnosis, treatment, and care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11384385

• Gastroparesis and brain–gut connections in children

  This project is building a national registry of children and teens with gastroparesis or similar nausea and vomiting conditions to learn what makes symptoms and quality of life worse.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11363811

• Pediatric Gastroparesis Registry 2: tracking symptoms and gastric emptying in kids and young adults

  This registry follows children, teens, and young adults (ages 8–25) with symptoms like nausea, vomiting, bloating, early fullness, or abdominal pain to document symptom patterns, gastric emptying, and quality of life over time.

  NIH research Texas Tech University Health Sciences Center at El Paso · El Paso, United States · NIH-11354505

• Understanding gastroparesis in children and teens

  This project is building a national registry to learn more about gastroparesis and similar stomach conditions in children and adolescents.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11337071

• Novel MRI to see how diabetes affects stomach emptying

  Advanced MRI is being used to watch how the stomach moves and empties in people with diabetes who have slow stomach emptying.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11181323

• Temple University Gastroparesis Clinical Center

  This program follows people with gastroparesis to learn what causes symptoms, to look at immune and pyloric muscle changes, and to try treatments such as buspirone.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11171447

• Improving diagnosis and care for gastroparesis and related stomach disorders

  This project will grow a patient registry and test whether the drug pioglitazone can help adults with gastroparesis and related functional dyspepsia.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11161590

• Understanding how the brain and nerves affect gastroparesis symptoms

  This project will look at biological and psychological causes of chronic gastroparesis and try a cognitive behavioral therapy approach to help people with ongoing nausea, vomiting, fullness, and pain.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11159453

• Understanding different types of gastroparesis and similar stomach‑emptying problems

  This project uses stomach muscle and nerve tests plus procedures and medication trials to find distinct types of gastroparesis and help people with chronic upper‑abdominal symptoms.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11158974

• Improving understanding and treatment of gastroparesis at the University of Louisville

  This consortium effort brings clinical experts together to learn more about what causes gastroparesis and to improve care for people with delayed stomach emptying, nausea, vomiting, and related symptoms.

  NIH research University of Louisville · Louisville, United States · NIH-11158674

• Gastroparesis data center supporting patient trials and registries

  This program runs and coordinates clinical trials and patient registries to test new treatments and collect health and sample data for adults and children with gastroparesis.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11158619

• Understanding delayed stomach emptying and indigestion in children

  This project collects health information from children and teens with delayed stomach emptying or related indigestion symptoms to create and confirm child-friendly symptom and quality-of-life questionnaires.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11158609

• Prucalopride to help symptoms of diabetic and idiopathic gastroparesis

  People with diabetic or idiopathic gastroparesis are given prucalopride or a placebo to see if taking prucalopride eases stomach-emptying problems and related symptoms.

  NIH research Texas Tech University Health Sciences Center at El Paso · El Paso, United States · NIH-11158600

• How immune cells in the stomach may drive gastroparesis

  This work looks at whether specific immune cells in the stomach differ in people with gastroparesis and how those differences link to delayed emptying and symptoms.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11144478

• Individual cell analysis of diabetes-related slow stomach emptying

  The team compares individual stomach and blood immune cells from people with and without diabetes who have upper‑GI symptoms to find how diabetes contributes to slow stomach emptying.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11144379

• Exploring new MRI technology to understand diabetic gastroparesis

  This study is looking at how food moves through the stomach in people with diabetic gastroparesis, using special MRI technology to help us understand the problem better and find new ways to treat it.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10912689

• Investigating the cellular mechanisms of diabetic gastroparesis

  This study is looking at how diabetes affects stomach function and aims to find new ways to help people with diabetes-related stomach problems by examining immune cells from both the stomach and blood of patients with and without diabetes.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10894674

• Understanding immune cells' role in gastroparesis

  This study is looking at how certain immune cells in the stomach might be affecting people with gastroparesis, a condition that makes it hard for the stomach to empty properly, and it hopes to find new ways to help manage the symptoms.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10889075

• Understanding how diabetes affects stomach emptying

  This study is looking into how diabetes affects certain immune cells in the stomach, which may help explain why some people with diabetes experience slow stomach emptying, and the goal is to find new ways to manage this issue.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10839767

• A new endoscopic procedure to treat severe stomach emptying issues.

  This study is looking at a new, less invasive surgery called per-oral pyloromyotomy (POP) to see if it helps people with gastroparesis feel better and improve their quality of life, compared to a fake treatment.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-10825515

Related topics

Quick answers

How many Gastroparesis clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (19 trials), China (2 trials), Germany (1 trial), Australia (1 trial), New Zealand (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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