Prucalopride for gastroparesis in adults: a multi-site trial
Official title: A multicenter, double-blind, randomized, placebo- controlled, parallel study to assess the efficacy of 5- HT4 agonist prucalopride for the treatment of diabetic and idiopathic gastroparesis
Funded at Texas Tech University Health Sciences Center at El Paso · NIH-11393898 · Data updated 2026-11-12
A multicenter study tests a medicine called prucalopride to help adults with gastroparesis feel better and have fewer stomach symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Sciences Center at El Paso NIH-funded |
| Lab location | 1 site (El Paso, United States) |
| Project start | September 30, 2008 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $345,000 |
| NIH project number | 5U01DK074035-17 |
| Project ID | NIH-11393898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with diagnosed gastroparesis (diabetic or idiopathic) who meet study criteria and consent to participation.
✕Less likely to help
Patients without gastroparesis or who do not meet inclusion criteria are unlikely to benefit from this trial.
What this research studies
This study plans to enroll adults with gastroparesis at several centers to see if prucalopride improves their symptoms compared with a placebo. It uses a double-blind design so neither participants nor researchers know who receives the medicine, and it follows patients over time to monitor effects and safety. The researchers will collect clinical data and tissue samples to understand how the drug works in the stomach and to explore related mechanisms. Outcomes will include symptom relief, gastric motility, and any adverse effects. The project builds on existing GP registries and tissue-biology analyses to deepen knowledge about gastroparesis.
Why it matters
Potential benefit: If successful, prucalopride could provide symptom relief and improve quality of life for many people with gastroparesis.
How similar studies have gone: Previous similar trials have shown variable results; this study aims to confirm efficacy in a larger, diverse patient group.
Where this research is happening
-
Texas Tech University Health Sciences Center at El Paso
El Paso, United States Active
Researchers
- Principal investigator: Sarosiek, Irene — Texas Tech University Health Sciences Center at El Paso
- Study coordinator: Sarosiek, Irene
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
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Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
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Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.