A new endoscopic procedure to treat severe stomach emptying issues.
Official title: Per-Oral Pyloromyotomy (POP) in the treatment of medical refractory gastroparesis : A randomized, sham-controlled trial
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10825515 · Data updated 2026-11-12
This study is looking at a new, less invasive surgery called per-oral pyloromyotomy (POP) to see if it helps people with gastroparesis feel better and improve their quality of life, compared to a fake treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 15, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $270,480 |
| NIH project number | 5R01DK120830-05 |
| Project ID | NIH-10825515 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with gastroparesis who have not responded adequately to standard medical treatments.
✕Less likely to help
Patients with mechanical obstructions in the stomach or those who have not been diagnosed with gastroparesis may not benefit from this research.
What this research studies
This research investigates the effectiveness of a novel endoscopic surgery called per-oral pyloromyotomy (POP) for patients suffering from gastroparesis, a condition that causes delayed stomach emptying. The study compares the outcomes of this procedure against a sham treatment to determine its true efficacy. Patients will undergo this minimally invasive procedure, which aims to relieve symptoms without the need for more invasive surgeries. The research will track improvements in symptoms and quality of life for participants over time.
Why it matters
Potential benefit: If successful, this research could provide a less invasive treatment option for patients with medically refractory gastroparesis, potentially improving their quality of life.
How similar studies have gone: Previous small-scale studies have shown promising results for the use of per-oral pyloromyotomy in treating gastroparesis, indicating potential for success in this larger trial.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Allemang, Matthew Thomas — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Allemang, Matthew Thomas
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
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Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.