A new endoscopic procedure to treat severe stomach emptying issues.
Per-Oral Pyloromyotomy (POP) in the treatment of medical refractory gastroparesis : A randomized, sham-controlled trial
This study is looking at a new, less invasive surgery called per-oral pyloromyotomy (POP) to see if it helps people with gastroparesis feel better and improve their quality of life, compared to a fake treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10825515 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of a novel endoscopic surgery called per-oral pyloromyotomy (POP) for patients suffering from gastroparesis, a condition that causes delayed stomach emptying. The study compares the outcomes of this procedure against a sham treatment to determine its true efficacy. Patients will undergo this minimally invasive procedure, which aims to relieve symptoms without the need for more invasive surgeries. The research will track improvements in symptoms and quality of life for participants over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gastroparesis who have not responded adequately to standard medical treatments.
Not a fit: Patients with mechanical obstructions in the stomach or those who have not been diagnosed with gastroparesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a less invasive treatment option for patients with medically refractory gastroparesis, potentially improving their quality of life.
How similar studies have performed: Previous small-scale studies have shown promising results for the use of per-oral pyloromyotomy in treating gastroparesis, indicating potential for success in this larger trial.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Allemang, Matthew Thomas — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Allemang, Matthew Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.