Gut-resident macrophages and gastric function in gastroparesis
Official title: Gut-resident macrophage regulation of gastric dysmotility and barrier dysfunction in gastroparesis
Funded at University of Nevada Reno · NIH-11430037 · Data updated 2026-11-12
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | September 9, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $642,756 |
| NIH project number | 1R01DK148906-01 |
| Project ID | NIH-11430037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with gastroparesis who are eligible for research participation and can undergo gut-related assessments.
✕Less likely to help
People without gastroparesis or those unable to participate due to medical or logistical reasons may not benefit.
What this research studies
Gastroparesis causes slow stomach emptying and a poor quality of life, and there are no disease-modifying therapies yet. This research tests a macrophage-focused model of gastroparesis using human-relevant analyses to explore how immune cells in the gut influence nerve and muscle function and the gut barrier. The team will integrate multi-omics profiling and functional studies to trace signals from the gut lining to the stomach, aiming to identify new therapeutic targets centered on the miR-10b–KLF7–IL-6 axis. If successful, the work could inform strategies not only for gastroparesis but also other gut-brain and barrier-dysfunction conditions.
Why it matters
Potential benefit: If successful, the findings could lead to new treatments that improve gastric motility and gut barrier health for people with gastroparesis.
How similar studies have gone: Previous work suggests immune and barrier components influence gut motility, but this macrophage-focused model in gastroparesis is relatively novel and exploratory.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Singh, Rajan — University of Nevada Reno
- Study coordinator: Singh, Rajan
Related research
Other NIH-funded projects on the same topics.
-
New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
-
Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
-
Prucalopride for gastroparesis in adults: a multi-site trial
A multicenter study tests a medicine called prucalopride to help adults with gastroparesis feel better and have fewer stomach symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.