New England Gastroparesis Consortium: Neurobiology of Gastroparesis
Official title: New England Gastropareis Consortium: Neurobiology of Gastroparesis
Funded at Massachusetts General Hospital · NIH-11384657 · Data updated 2026-11-12
A multi-site project to understand the brain and gut factors behind gastroparesis and to test a potential cognitive behavioral therapy to help people living with this condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 25, 2016 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $420,000 |
| NIH project number | 5U01DK112193-10 |
| Project ID | NIH-11384657 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with gastroparesis enrolled in the New England Gastroparesis Collaborative or similar registries.
✕Less likely to help
People without gastroparesis or those not engaging in psychotherapy components may not experience direct benefits.
What this research studies
This project builds on a nationwide effort to better characterize gastroparesis by looking at biopsychosocial factors that influence symptoms and quality of life. It will continue a multi-center registry and recruit participants to study how nervous system and psychological aspects relate to gastroparesis in everyday life. At Massachusetts General Hospital, researchers will explore novel biopsychosocial contributors to symptoms and test the preliminary effectiveness of a cognitive behavioral therapy approach. If successful, these insights could lead to more personalized care that targets both mind and body in gastroparesis. The study emphasizes patient-reported experiences and aims to translate findings into practical strategies for symptom relief and improved daily functioning.
Why it matters
Potential benefit: If successful, the work could lead to new, brain-gut–based treatments and supportive therapies that improve daily functioning and quality of life for people with gastroparesis.
How similar studies have gone: Prior research has shown that addressing biopsychosocial factors and providing behavioral therapy can help manage gastroparesis symptoms in some patients.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Burton Murray, Helen — Massachusetts General Hospital
- Study coordinator: Burton Murray, Helen
Related research
Other NIH-funded projects on the same topics.
-
New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
-
Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.