Understanding how diabetes affects stomach emptying
Pathophysiology of Diabetic Gastroparesis
This study is looking into how diabetes affects certain immune cells in the stomach, which may help explain why some people with diabetes experience slow stomach emptying, and the goal is to find new ways to manage this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10839767 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind diabetic gastroparesis, a condition where the stomach takes too long to empty its contents. It focuses on how diabetes alters the behavior of immune cells, specifically monocytes and macrophages, in the stomach's muscular layer. By studying diabetic mice and human samples, the researchers aim to uncover the genetic and environmental factors that contribute to delayed gastric emptying. The findings could lead to new insights into managing this complication of diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who experience symptoms of gastroparesis, such as nausea, vomiting, and bloating.
Not a fit: Patients without diabetes or those who do not experience gastric emptying issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from diabetic gastroparesis.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in gastrointestinal disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Farrugia, Gianrico — Mayo Clinic Rochester
- Study coordinator: Farrugia, Gianrico
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.