Understanding how diabetes affects stomach emptying
Official title: Pathophysiology of Diabetic Gastroparesis
Funded at Mayo Clinic Rochester · NIH-10839767 · Data updated 2026-11-12
This study is looking into how diabetes affects certain immune cells in the stomach, which may help explain why some people with diabetes experience slow stomach emptying, and the goal is to find new ways to manage this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 15, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $514,330 |
| NIH project number | 5R01DK127992-04 |
| Project ID | NIH-10839767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who experience symptoms of gastroparesis, such as nausea, vomiting, and bloating.
✕Less likely to help
Patients without diabetes or those who do not experience gastric emptying issues may not benefit from this research.
What this research studies
This research investigates the mechanisms behind diabetic gastroparesis, a condition where the stomach takes too long to empty its contents. It focuses on how diabetes alters the behavior of immune cells, specifically monocytes and macrophages, in the stomach's muscular layer. By studying diabetic mice and human samples, the researchers aim to uncover the genetic and environmental factors that contribute to delayed gastric emptying. The findings could lead to new insights into managing this complication of diabetes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from diabetic gastroparesis.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cells in gastrointestinal disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Farrugia, Gianrico — Mayo Clinic Rochester
- Study coordinator: Farrugia, Gianrico
Related research
Other NIH-funded projects on the same topics.
-
New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
-
Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.