Exploring new MRI technology to understand diabetic gastroparesis
Official title: Use of novel MRI technology to study pathophysiology diabetic gastroparesis
Funded at University of Michigan at Ann Arbor · NIH-10912689 · Data updated 2026-11-12
This study is looking at how food moves through the stomach in people with diabetic gastroparesis, using special MRI technology to help us understand the problem better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 30, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $364,186 |
| NIH project number | 5R01DK131524-04 |
| Project ID | NIH-10912689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with long-standing diabetes who experience symptoms of delayed gastric emptying.
✕Less likely to help
Patients without diabetes or those who do not experience symptoms of gastroparesis may not benefit from this research.
What this research studies
This research investigates the complex process of gastric emptying in patients with diabetic gastroparesis, a condition often caused by poorly controlled diabetes. Using advanced contrast-enhanced MRI technology, the study aims to visualize and quantify gastric motility and emptying in both rats and humans. By analyzing the coordination of various gastric motor functions, the research seeks to uncover the underlying mechanisms of this disorder, which could lead to improved treatment options. Patients may benefit from a better understanding of their condition and the development of new therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from diabetic gastroparesis.
How similar studies have gone: Previous research using advanced imaging techniques has shown promise in understanding gastric motility, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Chen, Jiande — University of Michigan at Ann Arbor
- Study coordinator: Chen, Jiande
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
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Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
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Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.