Condition

Diabetes Mellitus, Type 1 clinical trials and research

• 68Clinical trials
• 28Countries

Newest Diabetes Mellitus, Type 1 clinical trials

All recruiting trials (68)

• Predictive CGM with App for people with type 1 or insulin-treated type 2 diabetes

  This study tests whether using the Accu-Chek SmartGuide CGM with its Predict App can reduce fear of hypoglycemia and improve related behaviors and confidence in adults with type 1 or insulin-treated type 2 diabetes.

  Recruiting Fidam Rdc · Bad Mergentheim, Baden-Wurttemberg · NCT07814508

• Tirzepatide for type 1 diabetes patients who are overweight or obese

  This study tests whether tirzepatide can affect stomach emptying in adults with type 1 diabetes and overweight or obesity.

  Recruiting Phase 1 Eli Lilly and Company · Miami, Florida · NCT07803744

• Oral insulin vs. subcutaneous insulin in adults with type 1 diabetes

  This study tests an oral insulin tablet (SCD0503) against subcutaneous insulin and placebo to see how it behaves in the blood and helps control blood sugar in adults with type 1 diabetes.

  Recruiting Phase 1 Sam Chun Dang Pharm. Co. Ltd. · Neuss, North Rhine-Westphalia · NCT07634770

• Genetic risk score and progression to insulin in type 1 diabetes

  This study tests whether a genetic risk score can predict which people with type 1 diabetes will need insulin progression over three years.

  Recruiting Second Xiangya Hospital of Central South University · Changsha, Hunan · NCT07621445

• Home-based use of an advanced hybrid closed-loop insulin pump with telemonitoring for adults with type 1 diabetes

  This study tests whether starting an advanced hybrid closed-loop insulin pump at home, with online education and telemonitoring, is feasible and safe for adults with type 1 diabetes.

  Recruiting Air Liquide Healthcare Spain · Cartagena, Murcia and 2 other locations · NCT07492992

• Diabetes multimorbidity and a voice diary app to help self-manage

  This study tests whether the Fabla-diabetesMM audio diary app is feasible and helpful for older adults with type 1 or type 2 diabetes who also have additional chronic conditions.

  Recruiting Emory University · Atlanta, Georgia · NCT07474376

• Eversense Gemini system with new flash glucose feature — testing accuracy and safety

  This will test whether the Eversense Gemini wearable glucose monitor with a new flash feature gives accurate and safe glucose readings for adults with type 1 or type 2 diabetes.

  Recruiting Senseonics, Inc. · Escondido, California · NCT07386340

• APGO automated insulin delivery with the TouchCare Nano patch pump for adults with type 1 diabetes

  This study will test whether the APGO algorithm in the Medtrum TouchCare Nano patch pump improves blood glucose control and is safe for adults with type 1 diabetes in everyday use.

  Recruiting Charles University, Czech Republic · Prague · NCT07320495

• Baricitinib to preserve insulin-producing beta cells in people newly diagnosed with type 1 diabetes

  This trial will test whether the drug baricitinib can help preserve insulin-producing beta cells in children and adults who were recently diagnosed with type 1 diabetes.

  Recruiting at 108 sites Phase 3 Eli Lilly and Company · Aurora, Colorado and 129 other locations · NCT07222332

• Baricitinib to delay the start of clinical (Stage 3) type 1 diabetes in at‑risk children and adults

  This will test whether the medicine baricitinib can delay the start of clinical type 1 diabetes in children and adults who are at high risk.

  Recruiting at 95 sites Phase 3 Eli Lilly and Company · Santa Barbara, California and 111 other locations · NCT07222137

• Control‑IQ automated insulin delivery for people with type 1 diabetes in France

  This project will try the Control‑IQ automated insulin pump (t:slim X2 with Dexcom G6/G7) in people with type 1 diabetes aged 6 and up in France to track safety, blood sugar control, and quality of life for 12 months.

  Recruiting at 25 sites Tandem Diabetes Care, Inc. · Agen and 24 other locations · NCT07211126

• How a child's new Type 1 diabetes diagnosis may change parents' diets

  This will see if parents of a child newly diagnosed with Type 1 diabetes change their own diets during the first year after diagnosis.

  Recruiting Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT07142681

• E-islet 01 therapy for people with long-standing Type 1 diabetes and impaired hypoglycemia awareness

  This trial will test whether E-islet 01, an allogeneic human islet cell therapy, is safe and helps reduce severe or unrecognized low blood sugars in people with Type 1 diabetes of more than five years’ duration.

  Recruiting Phase 1/2 EndoCell Therapeutics, Inc. · Shanghai, Shanghai Municipality · NCT07126873

• Cognitive behavioral therapy for insomnia in adults with type 1 diabetes

  This trial will test whether virtual cognitive behavioral therapy for insomnia (CBT-I) helps adults with type 1 diabetes sleep better and improves blood sugar control and quality of life.

  Recruiting Early Phase 1 University of Illinois Chicago · Chicago, Illinois · NCT07091318

• Repeated rituximab infusions for recent-onset type 1 diabetes in adolescents

  This test tries repeated rituximab infusions alongside regular insulin in adolescents 12–17 with recent-onset type 1 diabetes to see if it helps preserve their insulin-producing beta cells.

  Recruiting at 2 sites Phase 2 Pirogov Russian National Research Medical University · Moscow and 1 other locations · NCT07041268

• Evaluating LY4057996 in Healthy Individuals and Those with Type 1 and Type 2 Diabetes

  This study is testing a new drug called LY4057996 to see how well it is tolerated and what side effects it might have in healthy people and those with Type 1 or Type 2 diabetes.

  Recruiting Phase 1 Eli Lilly and Company · Neuss · NCT06945406

• ACTnow group program for diabetes distress in young adults with type 1 diabetes

  This will test whether a group ACT program called ACTnow can lower diabetes distress and improve mental well-being and blood sugar control in 18–35-year-olds with type 1 diabetes and moderate-to-severe diabetes distress.

  Recruiting at 3 sites Odense University Hospital · Esbjerg and 2 other locations · NCT06936280

• Improving access to advanced diabetes technology for people with Type 1 Diabetes

  This study is testing a new system to help doctors prescribe advanced diabetes tools more fairly for people with Type 1 Diabetes, especially focusing on reducing differences in access for non-white patients.

  Recruiting T1D Exchange, United States · Boston, Massachusetts and 1 other locations · NCT06931275

• Inhaled Technosphere versus rapid-acting insulin for exercise-related low blood sugar in adults with type 1 diabetes using automated insulin delivery

  This trial will test whether inhaled Technosphere insulin given at mealtime reduces exercise-related low blood sugar compared with usual rapid-acting insulin in adults 18–65 with type 1 diabetes who use Tandem Control‑IQ automated insulin pumps.

  Recruiting at 3 sites Jaeb Center for Health Research · Louisville, Kentucky and 2 other locations · NCT06880835

• Awiqli (insulin icodec) use and results in people with diabetes in Japan.

  This study will test Awiqli (insulin icodec) in people with diabetes to see if it's safe and works well during routine care in Japan.

  Recruiting at 25 sites Novo Nordisk A/S · Koriyama-shi, Fukushima, Fukushima, Japan and 115 other locations · NCT06807190

• Comparing fasted and post-meal exercise in people with type 1 diabetes

  This study tests whether exercising before meals helps people with type 1 diabetes manage their blood sugar better and use less insulin compared to exercising after meals.

  Recruiting University of Alberta · Edmonton, Alberta · NCT06748963

• RGB-5088 islet cell transplantation for Type 1 diabetes

  This trial will test whether transplanted RGB-5088 islet cells can safely reduce severe hypoglycemia and lower insulin needs in adults with Type 1 diabetes and very low C-peptide.

  Recruiting Phase 1 Hangzhou Reprogenix Bioscience, Inc · Tianjin, Tianjin Municipality · NCT06731218

• Treatment for pre-diabetes in children using Treg cells and rituximab

  This study is testing if using special immune cells and a medication can help children at high risk for type 1 diabetes avoid getting the disease.

  Recruiting at 8 sites Phase 2 PolTREG S.A. · Bialystok and 8 other locations · NCT06688331

• Investigating the safety and effectiveness of porcine pancreatic cells in patients with Type 1 diabetes

  This study is testing if using pig pancreas cells can help adults with tough-to-manage Type 1 diabetes feel better and avoid dangerous low blood sugar episodes.

  Recruiting Phase 1/2 Otsuka Pharmaceutical Factory, Inc. · Chicago, Illinois · NCT06575426

• Comparing single-session and multiple-session laser treatment for diabetic eye disease

  This study is testing whether one session or multiple sessions of laser treatment works better for people with newly diagnosed diabetic eye disease to help them keep their vision and avoid complications.

  Recruiting Vastra Gotaland Region · Mölndal · NCT06549023

• Testing a ketogenic diet for better blood sugar control in type 1 diabetes

  This study is testing if a very-low-carbohydrate ketogenic diet can help adults with type 1 diabetes manage their blood sugar better and reduce their need for insulin.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06503809

• Automated insulin delivery for type 1 diabetes

  This study is testing if using automated insulin delivery systems can improve sleep quality and heart health for people with type 1 diabetes compared to their usual treatment.

  Recruiting at 3 sites Steno Diabetes Center Copenhagen · Herlev, Greater Copenhagen and 2 other locations · NCT06469593

• Using hybrid closed-loop insulin pumps to improve diabetes management in diverse adults

  This study is testing if a new type of insulin pump can help adults with poorly controlled Type 1 Diabetes manage their condition better, especially those from different backgrounds who usually have trouble accessing diabetes technology.

  Recruiting at 3 sites University of California, Los Angeles · Santa Monica, California and 2 other locations · NCT06453928

• Vaccination to prevent type 1 diabetes in at-risk children

  This study is testing if giving a COVID-19 vaccine to young children at high risk for type 1 diabetes can help prevent the disease from developing.

  Recruiting at 6 sites Phase 4 Technical University of Munich · Vienna and 8 other locations · NCT06452654

• Combined mHealth-CBT for psychological well-being in young people with Type 1 diabetes

  This trial tests a mix of an app-based mHealth program plus in-person CBT sessions to see if it improves psychological well-being for children and teens with Type 1 diabetes.

  Recruiting Maimónides Biomedical Research Institute of Córdoba · Córdoba, Córdoba · NCT06450730

• Behavioral approaches to reduce diabetes distress in adults with type 1 diabetes

  This study tests two different group programs to see if they can help adults with type 1 diabetes feel less stressed about managing their condition.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT06405373

• Evaluating fetal hyperinsulinemia using ultrasound radiomics

  This study is testing if special ultrasound images can help tell if babies are at risk for high insulin levels when their mothers have type 1 diabetes, compared to healthy pregnancies.

  Recruiting at 2 sites Turku University Hospital · Turku and 1 other locations · NCT06343974

• Program to reduce food insecurity for hospitalized diabetics

  This study tests whether providing better access to healthy meals and nutrition education can help hospitalized patients with diabetes feel better and improve their overall health.

  Recruiting Stanford University · Palo Alto, California · NCT06329375

• Restoring low-blood-sugar awareness with closed-loop pumps or targeted education

  This study will test whether using hybrid closed-loop insulin systems or focused education can help adults with type 1 diabetes who no longer notice low blood sugar regain their awareness.

  Recruiting at 8 sites Milton S. Hershey Medical Center · La Jolla, California and 7 other locations · NCT06325202

• Insulin sensitivity patterns across the menstrual cycle in women with type 1 diabetes

  This project will use data from your automated insulin delivery system, glucose records, nutrition logs, and menstrual cycle notes to see if insulin needs and glucose patterns change across menstrual cycles in women with type 1 diabetes.

  Recruiting DCB Research AG · Bern · NCT06282055

• Evaluating hybrid closed loop therapy for adults with type 1 diabetes from underserved communities

  This study is testing if a new type of insulin pump therapy can help adults with type 1 diabetes from underserved communities manage their blood sugar better and improve their overall health.

  Recruiting at 2 sites Boston Medical Center · Boston, Massachusetts and 1 other locations · NCT06236607

• Using Sotagliflozin to Slow Kidney Decline in Type 1 Diabetes Patients

  This study is testing if sotagliflozin can help slow down kidney problems in people with type 1 diabetes and kidney disease.

  Recruiting at 19 sites Phase 3 Joslin Diabetes Center · Stanford, California and 18 other locations · NCT06217302

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Assessing gastric functions in patients with diabetes

  This study looks at how diabetes affects stomach function in people with Type 1 and Type 2 diabetes to see if there are any problems and how these issues relate to their overall health.

  Recruiting at 5 sites Institute for Clinical and Experimental Medicine · Ostrava and 4 other locations · NCT06068114

• Impact of Enhanced Care for Adults with Type 1 Diabetes Using Insulin Pumps

  This study is testing whether getting extra support from pharmacists helps adults with Type 1 diabetes using insulin pumps feel less stressed about their condition over a year.

  Recruiting timkl · Nice, Paca · NCT06050642

• Evaluating glucose metrics in diabetes patients with and without gastroparesis

  This study is testing how glucose levels change in people with diabetes who have gastroparesis compared to those who don’t, using a continuous glucose monitor to help spot early signs of gastroparesis.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06046833

• Comparing Lisdexamphetamine and Methylphenidate for Kids with ADHD and Type 1 Diabetes

  This study is testing whether two different medications can help kids aged 8 to 16 with both ADHD and Type 1 Diabetes feel better and manage their symptoms more effectively.

  Recruiting Phase 2 Medical University of Lodz · Lodz, Łódź Voivodeship · NCT05957055

• Effects of a ketogenic diet on type 1 diabetes in children

  This study is testing if a ketogenic diet can help young children with newly diagnosed type 1 diabetes manage their condition better and stay healthy for longer.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05899166

• Improving access to advanced diabetes technology for children with Type 1 Diabetes

  This study is testing if giving advanced diabetes technology to children and teens with Type 1 Diabetes from lower-income backgrounds can help them manage their condition better.

  Recruiting Nemours Children's Clinic · Jacksonville, Florida and 1 other locations · NCT05849753

• Effects of semaglutide on heart health in type 1 diabetes

  This study is testing whether the medication semaglutide can improve heart and kidney health in adults with type 1 diabetes.

  Recruiting at 2 sites Phase 3 University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT05819138

• Exercise program for improving health in young adults with Type 1 Diabetes

  This study is testing whether a structured exercise program can help young adults with Type 1 Diabetes improve their muscle health and reduce complications related to their condition.

  Recruiting McMaster University · Hamilton, Ontario · NCT05740514

• Optimizing diabetes foot care using eHealth tools

  This study is testing a new way to use digital tools to help people with diabetes take better care of their feet and prevent foot ulcers.

  Recruiting Sahlgrenska University Hospital · Gothenburg · NCT05692778

• Evaluating CELZ-201 for recent onset Type 1 Diabetes

  This study is testing a new treatment called CELZ-201 to see if it can help people who have recently been diagnosed with Type 1 Diabetes feel better when used alongside their usual care.

  Recruiting Phase 1/2 Creative Medical Technology Holdings Inc · Miami, Florida · NCT05626712

• Measuring a new biomarker in children with type 1 diabetes

  This study is testing a new blood marker in children with type 1 diabetes to see if it can help measure how well their insulin-producing cells are working.

  Recruiting University Hospital, Geneva · Geneva, Canton of Geneva · NCT05594706

• Observational study on fulminant type 1 diabetes in China

  This study is trying to learn more about fulminant type 1 diabetes by looking at the health data of patients experiencing it for the first time and comparing it to healthy individuals.

  Recruiting at 10 sites Second Xiangya Hospital of Central South University · Quanzhou, Fujian and 9 other locations · NCT05593081

• Using influenza vaccination to help manage type 1 diabetes

  This study is testing if getting the flu vaccine can help people with early type 1 diabetes keep their insulin-producing cells working better.

  Recruiting at 10 sites Phase 4 Aarhus University Hospital · Aalborg and 9 other locations · NCT05585983

• Improving blood flow in type 1 diabetes with medication and exercise

  This study is testing whether a combination of a medication called dulaglutide and exercise can improve blood flow in adults with type 1 diabetes.

  Recruiting Phase 2 AdventHealth Translational Research Institute · Orlando, Florida · NCT05478707

• Effect of Dichloroacetate on Brain Function in Type 1 Diabetes During Hypoglycemia

  This study is testing if a drug called dichloroacetate can help people with Type 1 Diabetes think better during low blood sugar episodes by improving how their brains use glucose.

  Recruiting Early Phase 1 Yale University · New Haven, Connecticut · NCT05317455

• Diabetes education for formerly incarcerated individuals using a virtual app

  This study tests a new app that helps people with diabetes who have recently been released from prison learn how to manage their condition better.

  Recruiting at 2 sites University of Connecticut · Storrs, Connecticut and 1 other locations · NCT05286892

• Evaluating VX-880 for Type 1 Diabetes with Severe Hypoglycemia

  This study is testing if a new treatment called VX-880 can help people with Type 1 diabetes who have trouble sensing low blood sugar and have had severe low blood sugar episodes.

  Recruiting at 26 sites Phase 3 Vertex Pharmaceuticals Incorporated · Duarte, California and 28 other locations · NCT04786262

• National cohort study of people with type 1 diabetes in France

  This study looks at how changes in blood sugar levels and different insulin treatments affect heart health in people with type 1 diabetes over ten years.

  Recruiting Fondation Francophone pour la Recherche sur le Diabete · Paris · NCT04657783

• Registry for individuals with type 1 diabetes

  This study is collecting information from people with type 1 diabetes to help researchers understand the condition better and improve diabetes management.

  Recruiting T1D Exchange, United States · Boston, Massachusetts · NCT04629586

• Improving diabetes control in kids using telehealth

  This study is testing if using video calls and remote monitoring can help kids with type 1 diabetes manage their blood sugar better than just regular check-ups.

  Recruiting University of California, Davis · Sacramento, California · NCT04428658

• Real-time continuous glucose monitoring for young adults at risk of DKA

  This project will try a Dexcom G6 real-time continuous glucose monitor to see if it helps 18-25-year-olds with insulin-treated diabetes who have poor blood sugar control or recent hospital admissions for high blood sugar.

  Recruiting Imperial College London · London · NCT04039763

• Identifying Monogenic Diabetes Misdiagnosed as Type 1

  This study is trying to find out how often young people are wrongly diagnosed with type 1 diabetes when they actually have a rare form called monogenic diabetes, by testing their blood and looking for specific genetic changes.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT03988764

• Transplanting stem cells and islet cells in children with type 1 diabetes and immune deficiency

  This study is testing if giving children with type 1 diabetes and immune problems a transplant of stem cells followed by insulin-producing cells can help them feel better and possibly cure their conditions.

  Recruiting Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT03835312

• Using Gastrin to Improve Islet Transplant Outcomes for Type 1 Diabetes

  This study is testing if giving Gastrin injections after an islet transplant can help people with tough-to-manage type 1 diabetes have better blood sugar control by improving the function of the transplanted insulin-producing cells.

  Recruiting Phase 1/2 City of Hope Medical Center · Duarte, California · NCT03746769

• Understanding the genetics of autoimmune responses in type 1 diabetes

  This study is trying to understand how genes and the environment affect the development of type 1 diabetes by looking at families with a history of the disease and healthy individuals.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT03648918

• Exploring how sleep patterns affect diabetes management

  This study is trying to see how different sleep patterns affect diabetes management in people aged 18 to 75 who have been living with diabetes for over six months.

  Recruiting University of Leicester · Leicester · NCT02973412

• Islet transplantation for patients with brittle Type 1 diabetes

  This study is testing whether islet transplantation can help people with brittle Type 1 diabetes manage their blood sugar better without needing insulin shots.

  Recruiting University of Chicago · Chicago, Illinois · NCT01630850

• Islet transplantation for better blood sugar control in type 1 diabetes after kidney transplant

  This study tests whether getting islet cells from donors after a kidney transplant can help people with type 1 diabetes control their blood sugar better without needing insulin shots.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT01241864

• Observational study on newly diagnosed diabetes and its complications

  This study looks at the health and lifestyle of newly diagnosed adults with diabetes to see how their condition changes over time compared to people without diabetes.

  Recruiting German Diabetes Center · Düsseldorf, North Rhine-Westphalia · NCT01055093

• Pathway to Prevention of Type 1 Diabetes

  This study is trying to see if a simple blood test can help identify people at risk for type 1 diabetes so they can be monitored and potentially prevent the disease.

  Recruiting at 19 sites University of South Florida · Orange, California and 21 other locations · NCT00097292

Related topics

Quick answers

How many Diabetes Mellitus, Type 1 clinical trials are recruiting right now?

68, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in United States (33 trials), Canada (8 trials), Germany (8 trials), United Kingdom (8 trials), France (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 5, Phase 2: 5, Phase 1: 4, Phase 1/2: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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