Condition

Constipation clinical trials and research

• 37Clinical trials
• 10NIH research projects
• 5New in 30 days
• 17Countries

Newest Constipation clinical trials

All recruiting trials (37)

• Gut health follow-along with Peachbiotic in adults

  This single-arm study tests whether Peachbiotic taken daily for 12 weeks helps adults with gut symptoms feel better.

  Recruiting Peach Perfect · Las Vegas, Nevada · NCT07927907

• Prebiotic and Probiotic Combo for Constipation Symptoms

  This study tests whether adding 1-kestose to a probiotic (BBH112) helps adults with constipation-related symptoms see more relief and better quality of life.

  Recruiting Seoul National University Hospital · Seongnam-si, Gyeonggi-do · NCT07923279

• Constipation Prevention Checklist in hip surgery patients

  A simple checklist is used to see if hip surgery patients can stay regular by staying hydrated, eating well, moving early, and using abdominal massage.

  Recruiting Cumhuriyet University · Sivas · NCT07895316

• Abdominal massage training for caregivers to help manage constipation

  Caregivers receive training to use abdominal massage and help their loved ones with constipation in palliative care to see if it improves symptoms and caregiver confidence.

  Recruiting Saglik Bilimleri Universitesi · Istanbul · NCT07886125

• Relationship between body awareness and posture in IBS-C patients compared with healthy people

  This study tests whether people with constipation-predominant IBS have different interoceptive awareness and posture compared with healthy controls.

  Recruiting Saglik Bilimleri Universitesi · Istanbul · NCT07870915

• Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns

  This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.

  Recruiting University of Cambridge · Cambridge, CB2 · NCT07786116

• Probiotics for constipation in adults

  This randomized, placebo-controlled study tests whether probiotics can help adults with constipation, compared with a placebo over 8 weeks.

  Recruiting Wecare Probiotics Co., Ltd. · Suzhou, Jiangsu · NCT07765004

• Radicle GI Health VNB: A test of health and wellness products for constipation

  This study tests whether Radicle GI Health products can improve constipation symptoms in adults in the U.S., compared with a placebo, while keeping participants blind to the product identity.

  Recruiting Radicle Science · Del Mar, California · NCT07713810

• Test anxiety and bowel health in university students

  This observational study tests whether stress from exams is linked to bowel health and constipation in university students during final exams.

  Recruiting Lokman Hekim University · Ankara, Ankara · NCT07654959

• Brenipatide (LY3537031) for IBS with constipation

  This trial will test whether brenipatide (LY3537031), given by a small under-the-skin injection, helps adults with IBS-C have less belly pain and more normal bowel movements compared with a placebo.

  Recruiting at 64 sites Phase 2 Eli Lilly and Company · Mesa, Arizona and 69 other locations · NCT07545772

• Probiotics vs. placebo for adults with constipation

  This trial tests whether daily probiotics for 8 weeks help adults with constipation compared with a non-active placebo.

  Recruiting Wecare Probiotics Co., Ltd. · Suzhou, Jiangsu · NCT07529457

• Probiotic to ease chronic constipation

  This trial will test whether a daily probiotic supplement helps adults with chronic constipation have more regular bowel movements compared with a placebo.

  Recruiting Wecare Probiotics Co., Ltd. · Suzhou, Jiangsu · NCT07462481

• BioAmicus Complete probiotic drops for infant tummy and skin issues

  This test will see if daily BioAmicus Complete probiotic drops help infants (about 1 to 4 months old) with colic, constipation, diarrhea, reflux, or atopic dermatitis.

  Recruiting NovoNatum Ltd · Saint Petersburg · NCT07444008

• Daily Weizmannia (Bacillus) coagulans JBI-YZ6.3 for constipation and gut health in active adults

  This test will see if taking a daily Weizmannia (Bacillus) coagulans JBI‑YZ6.3 probiotic improves constipation and other gut symptoms in healthy, physically active adults aged 18–50.

  Recruiting Lindenwood University · Saint Charles, Missouri · NCT07388264

• Treating dyssynergic defecation and constipation

  This trial tests whether biofeedback therapy, with or without inspiratory muscle training, helps adults with dyssynergic defecation or chronic constipation improve bowel function.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07225803

• TCI604 probiotic to improve intestinal function

  This trial will test whether the TCI604 probiotic can improve gut function and relieve constipation in adults with functional constipation.

  Recruiting TCI Co., Ltd. · Taipei · NCT07135362

• Ma-Zi-Ren-Wan (MZRW) herbal treatment for constipation in cancer survivors

  This will see if the herbal formula Ma-Zi-Ren-Wan (MZRW) helps relieve functional constipation in adult cancer survivors compared with a placebo.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07091084

• LcS-fermented milk for constipation in Filipino adults

  This trial will test whether a daily probiotic drink containing Lacticaseibacillus paracasei strain Shirota (LcS) helps Filipino adults with constipation get softer stools and more regular bowel movements and reduce gastrointestinal discomfort.

  Recruiting University of Santo Tomas · Manila, Manila · NCT07083596

• Self-administered acupressure for constipation in adult psychiatric inpatients

  This project tests whether adult psychiatric inpatients can reduce constipation symptoms by using self-administered acupressure.

  Recruiting Hong Kong Metropolitan University · Tuenmen, New Territories · NCT07039448

• Probiotics for preventing constipation in children

  This study is testing whether a probiotic called BioKid LR can help children aged 6 months to 17 years avoid constipation after stopping laxatives.

  Recruiting Phase 4 HaEmek Medical Center, Israel · Afula · NCT06959758

• Podcast to prevent constipation before and after orthopedic surgery

  This study is testing whether a podcast that shares tips about preventing constipation can help patients having orthopedic surgery avoid this problem before and after their operations.

  Recruiting Central Jutland Regional Hospital · Silkeborg · NCT06877078

• Microbiome transplant to treat constipation and bloating in systemic sclerosis

  This Phase 2 trial tests whether a frozen or lyophilized microbiome transplant (PRIM‑DJ2727) can help people with systemic sclerosis who have constipation and/or significant bloating.

  Recruiting Phase 2 The University of Texas Health Science Center, Houston · Houston, Texas · NCT06827977

• Online pelvic health program for breast and gynecologic cancer survivors

  This study is testing an online program to help breast and gynecologic cancer survivors improve their pelvic health and quality of life through group sessions with a physiotherapist.

  Recruiting at 2 sites Laval University · Edmonton, Alberta and 1 other locations · NCT06822582

• Comparing Remimazolam and Propofol for sedation during endoscopic procedures

  This study is testing whether using Remimazolam alone, Propofol alone, or a combination of both can provide better and safer sedation for patients undergoing endoscopic procedures.

  Recruiting Phase 4 Kaohsiung Veterans General Hospital. · Kaohsiung City · NCT06777758

• Evaluating the effectiveness of Danning Tablets for digestive symptoms

  This study is testing if Danning Tablets can help people aged 18 to 75 feel better from digestive issues like indigestion and bloating while they are already using the medication.

  Recruiting Shanghai Hutchison Pharmaceuticals Limited · Hangzhou, Zhejiang · NCT06755671

• Acupuncture for treating constipation in Parkinson's disease

  This study is testing if acupuncture can help people with Parkinson's disease who have constipation feel better by increasing their bowel movements.

  Recruiting Xi'an No.3 Hospital · Xi'an, Shaanxi · NCT06390761

• Optimizing bowel habits after pelvic surgery

  This study tests whether taking oral senna or using rectal bisacodyl suppositories can help women who have had vaginal surgery for pelvic organ prolapse avoid constipation after their surgery.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06335797

• Washing and transplanting gut bacteria to treat chronic constipation

  This study is testing if washing and transplanting gut bacteria can help adults with chronic constipation feel better.

  Recruiting at 2 sites Phase 1/2 The Second Hospital of Nanjing Medical University · Nanjing, Jiangsu and 1 other locations · NCT06106685

• Exploring how electrical stimulation affects constipation in systemic sclerosis patients

  This study is testing whether a new electrical stimulation treatment can help people with systemic sclerosis who have constipation feel better by improving how their digestive system works.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05989763

• Evaluating changes in gut bacteria after enema treatment for constipation in children

  This study is testing how a special enema treatment for constipation affects the gut bacteria in children aged 2 to 18 over several months.

  Recruiting at 2 sites Phase 4 Indiana University · Carmel, Indiana and 1 other locations · NCT05821309

• Using a new device to improve biofeedback therapy for constipation patients

  This study is testing a new device to see if it can help doctors figure out which constipation patients will benefit from biofeedback therapy.

  Recruiting at 2 sites The California Medical Innovations Institute, Inc. · San Diego, California and 1 other locations · NCT05807321

• Using preoperative laxatives to improve recovery after robotic urologic surgery

  This study is testing if taking a laxative before robotic surgery for prostate or kidney cancer can help patients recover better and feel less discomfort afterward.

  Recruiting Phase 4 University of Iowa · Iowa City, Iowa · NCT05805436

• Using pyridostigmine to treat constipation in Parkinson's disease

  This study is testing if pyridostigmine can help people with Parkinson's disease who struggle with chronic constipation feel better.

  Recruiting Phase 2 University of Vermont Medical Center · Burlington, Vermont · NCT05603715

• High-resolution manometry for chronic constipation

  This study will test whether high-resolution manometry can better detect abnormal colorectal muscle activity in adults (18–65) with chronic constipation that has not improved with laxatives.

  Recruiting at 3 sites University Hospital, Rouen · Caen and 2 other locations · NCT04623359

• Registry for gastrointestinal motility disorders at Indiana University

  This study is creating a detailed list of patients with gastrointestinal motility disorders to help doctors better understand and treat these conditions.

  Recruiting Indiana University · Indianapolis, Indiana · NCT04506593

• Using fecal microbiota transplantation to treat gut disorders

  This study is testing whether a treatment that involves using healthy stool to help restore gut bacteria can improve symptoms for people with gut disorders like Crohn's disease and irritable bowel syndrome.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04014413

• Understanding why constipation happens and improving diagnosis

  This study is trying to find out why constipation happens and improve how it's diagnosed by looking at bowel habits and taking samples from people who have this issue.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03842007

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding constipation in systemic sclerosis and how autonomic stimulation may help

  A patient-centered look at a study testing whether stimulating the autonomic nervous system can improve constipation in people with systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11381944

• Abdominal Myofascial Release for IBS-C in patients of all ages

  A study tests a hands-on therapy called abdominal myofascial release to help kids, teens, and adults with IBS with constipation feel better and have fewer tummy symptoms.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11287557

• A New Way to Understand Chronic Constipation

  This project aims to better understand chronic constipation and improve how we identify its causes using a new device called Fecobionics.

  NIH research California Medical Innovations Institute · San Diego, United States · NIH-11164491

• Constipation treatment to improve gut and kidney health in people with chronic kidney disease

  This pilot will see if treating constipation improves gut bacteria, blood markers, and overall health in people with chronic kidney disease.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11159760

• Constipation in systemic sclerosis: nerve and muscle causes

  This project tests whether problems with gut nerves and pelvic floor muscles explain different types of constipation in people with systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11159431

• Developing an open-source system for nerve stimulation to treat chronic constipation.

  This study is testing a new, flexible device that helps stimulate nerves to treat chronic constipation, aiming to provide patients with a more effective and affordable treatment option.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11080155

• Improving care for patients with chronic constipation using a new clinical pathway

  This study is working on a new tool to help doctors quickly diagnose and treat chronic constipation, so patients can get the right care without going through lots of extra tests.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11018561

• Effects of treating constipation in patients with chronic kidney disease

  This study is looking at how treating constipation might help people with chronic kidney disease feel better and improve their overall health, by checking how laxatives can change gut health and other important health markers.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10906180

• How brain-gut interactions affect IBS and constipation symptoms in women during their menstrual cycle and menopause

  This study is looking at how the brain, gut bacteria, and hormone changes during your menstrual cycle and menopause affect IBS and constipation symptoms in women, and it’s inviting participants to help researchers learn more about these connections.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10903906

• Understanding constipation in patients with systemic sclerosis

  This study is looking into why people with systemic sclerosis often have constipation, focusing on how their body's nerves and muscles might be affecting their bowel movements, with the goal of finding better ways to help them feel better.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10896425

Related topics

Quick answers

How many Constipation clinical trials are recruiting right now?

37, as of November 12, 2026. 5 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (15 trials), China (7 trials), Turkey (Türkiye) (4 trials), United Kingdom (2 trials), Canada (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 2: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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