Understanding and Treating Gastroparesis: New Registry, Ongoing Studies, and a Possible Targeted Therapy
Official title: Advancing Science for the Diagnosis and Treatment of Gastroparesis
Funded at Mayo Clinic Arizona · NIH-11384498 · Data updated 2026-11-12
A Mayo Clinic team is proposing to improve diagnosis and treatment for gastroparesis and related conditions by finishing current studies, creating a larger patient registry, and exploring a potential therapy that targets immune activity in the stomach.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | April 15, 2006 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $160,495 |
| NIH project number | 5U01DK073983-20 |
| Project ID | NIH-11384498 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with gastroparesis or functional dyspepsia who can participate in registries, studies, and biological sample collection.
✕Less likely to help
Patients not willing or able to participate in registry enrollment, ongoing studies, or biological sampling.
What this research studies
This grant supports translational work on gastroparesis and functional dyspepsia, focusing on finishing existing studies, building a comprehensive registry of patients, and investigating how macrophage activity may influence symptoms. Researchers will use patient data and biological samples to better define disease characteristics, track outcomes, and identify subtypes that could respond to targeted treatments. The work aims to connect clinical findings with biology to move toward more accurate diagnosis and effective care for people living with these conditions.
Why it matters
Potential benefit: If successful, patients could receive faster diagnosis, more personalized treatment options, and better symptom relief.
How similar studies have gone: Previous work in gastroparesis has shown that multi-center registries and translational approaches can improve understanding and guide therapy.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Pasricha, Pankaj J — Mayo Clinic Arizona
- Study coordinator: Pasricha, Pankaj J
Related research
Other NIH-funded projects on the same topics.
-
New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
-
Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.