Gastroparesis and brain–gut connections in children
New England Gastropareis Consortium: Neurobiology of Gastroparesis
This project is building a national registry of children and teens with gastroparesis or similar nausea and vomiting conditions to learn what makes symptoms and quality of life worse.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11363811 on NIH RePORTER |
What this research studies
If your child joins, doctors at participating hospitals will enter medical history, symptom reports, quality-of-life questionnaires, and test results (like gastric emptying studies) into a secure, prospective registry and follow them over time. The team will use pediatric Rome IV criteria to classify conditions such as functional dyspepsia, chronic nausea‑vomiting syndrome, and cyclic vomiting, and will look for differences in symptom patterns and biology, including nervous‑system influences. Data from children and adolescents will be compared with adult findings to identify age-specific causes and outcomes. The goal is to find factors linked to worse symptoms and life impact that could guide better care for kids with these conditions.
Who could benefit from this research
Good fit: Children and adolescents diagnosed with gastroparesis or Gp-like disorders (including functional dyspepsia, chronic nausea/vomiting syndrome, or cyclic vomiting syndrome) are the intended participants.
Not a fit: People whose symptoms are caused by a mechanical blockage of the stomach or who do not have gastroparesis-like symptoms are unlikely to benefit from this registry.
Why it matters
Potential benefit: If successful, this work could improve diagnosis and help develop treatments tailored for children with gastroparesis and related disorders.
How similar studies have performed: There are prior adult and smaller pediatric registries and this project builds on Pediatric Gp Registry 2, but pediatric gastroparesis remains under-studied and many questions are unresolved.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Burton Murray, Helen — Massachusetts General Hospital
- Study coordinator: Burton Murray, Helen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.