Investigating the cellular mechanisms of diabetic gastroparesis
Official title: Single-cell epigenomics and transcriptomics of diabetic gastroparesis in humans
Funded at Mayo Clinic Rochester · NIH-10894674 · Data updated 2026-11-12
This study is looking at how diabetes affects stomach function and aims to find new ways to help people with diabetes-related stomach problems by examining immune cells from both the stomach and blood of patients with and without diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 30, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $381,600 |
| NIH project number | 5R01DK131455-04 |
| Project ID | NIH-10894674 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with diabetic gastroparesis or upper gastrointestinal symptoms related to diabetes.
✕Less likely to help
Patients without diabetes or those who do not experience gastrointestinal symptoms may not benefit from this research.
What this research studies
This research focuses on understanding the cellular and molecular mechanisms behind diabetic gastroparesis, a complication of diabetes that affects the stomach's ability to empty properly. By analyzing single immune cells from the stomach and blood, the study aims to uncover how diabetes-related factors influence gastrointestinal symptoms. Patients with and without diabetes who experience upper gastrointestinal issues will be carefully phenotyped and assessed both in vivo and ex vivo. The goal is to identify potential new therapeutic targets that address the underlying disease rather than just the symptoms.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diabetic gastroparesis, improving the quality of life for affected patients.
How similar studies have gone: Other research has shown promise in understanding similar gastrointestinal complications in diabetes, but this specific approach is relatively novel.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Bharucha, Adil E. — Mayo Clinic Rochester
- Study coordinator: Bharucha, Adil E.
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
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Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.