Investigating the cellular mechanisms of diabetic gastroparesis
Single-cell epigenomics and transcriptomics of diabetic gastroparesis in humans
This study is looking at how diabetes affects stomach function and aims to find new ways to help people with diabetes-related stomach problems by examining immune cells from both the stomach and blood of patients with and without diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10894674 on NIH RePORTER |
What this research studies
This research focuses on understanding the cellular and molecular mechanisms behind diabetic gastroparesis, a complication of diabetes that affects the stomach's ability to empty properly. By analyzing single immune cells from the stomach and blood, the study aims to uncover how diabetes-related factors influence gastrointestinal symptoms. Patients with and without diabetes who experience upper gastrointestinal issues will be carefully phenotyped and assessed both in vivo and ex vivo. The goal is to identify potential new therapeutic targets that address the underlying disease rather than just the symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with diabetic gastroparesis or upper gastrointestinal symptoms related to diabetes.
Not a fit: Patients without diabetes or those who do not experience gastrointestinal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diabetic gastroparesis, improving the quality of life for affected patients.
How similar studies have performed: Other research has shown promise in understanding similar gastrointestinal complications in diabetes, but this specific approach is relatively novel.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Bharucha, Adil E. — Mayo Clinic Rochester
- Study coordinator: Bharucha, Adil E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.