Understanding immune cells' role in gastroparesis
From stomach tissue to cellular mechanisms: unraveling the role of mononuclear phagocytes in the pathophysiology of gastroparesis
This study is looking at how certain immune cells in the stomach might be affecting people with gastroparesis, a condition that makes it hard for the stomach to empty properly, and it hopes to find new ways to help manage the symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10889075 on NIH RePORTER |
What this research studies
This research investigates the role of immune cells, specifically mononuclear phagocytes, in the gastrointestinal disorder known as gastroparesis, which causes delayed gastric emptying and various gastrointestinal symptoms. By analyzing stomach tissue samples from patients, the researchers aim to uncover how these immune cells are altered in gastroparesis and how these changes may contribute to the disease's symptoms. The study employs advanced techniques like mass cytometry to identify and characterize the immune cell populations in the stomach, providing insights that could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gastroparesis who experience symptoms like nausea, vomiting, and abdominal pain.
Not a fit: Patients without a diagnosis of gastroparesis or those with other gastrointestinal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing gastroparesis, potentially improving patients' quality of life.
How similar studies have performed: While the specific approach of examining immune cell dysregulation in gastroparesis is relatively novel, similar studies in other gastrointestinal disorders have shown promising results.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Idoyaga, Juliana — University of California, San Diego
- Study coordinator: Idoyaga, Juliana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.