Understanding immune cells' role in gastroparesis
Official title: From stomach tissue to cellular mechanisms: unraveling the role of mononuclear phagocytes in the pathophysiology of gastroparesis
Funded at University of California, San Diego · NIH-10889075 · Data updated 2026-11-12
This study is looking at how certain immune cells in the stomach might be affecting people with gastroparesis, a condition that makes it hard for the stomach to empty properly, and it hopes to find new ways to help manage the symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 30, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $379,199 |
| NIH project number | 5R01DK131500-05 |
| Project ID | NIH-10889075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with gastroparesis who experience symptoms like nausea, vomiting, and abdominal pain.
✕Less likely to help
Patients without a diagnosis of gastroparesis or those with other gastrointestinal disorders may not benefit from this research.
What this research studies
This research investigates the role of immune cells, specifically mononuclear phagocytes, in the gastrointestinal disorder known as gastroparesis, which causes delayed gastric emptying and various gastrointestinal symptoms. By analyzing stomach tissue samples from patients, the researchers aim to uncover how these immune cells are altered in gastroparesis and how these changes may contribute to the disease's symptoms. The study employs advanced techniques like mass cytometry to identify and characterize the immune cell populations in the stomach, providing insights that could lead to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing gastroparesis, potentially improving patients' quality of life.
How similar studies have gone: While the specific approach of examining immune cell dysregulation in gastroparesis is relatively novel, similar studies in other gastrointestinal disorders have shown promising results.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Idoyaga, Juliana — University of California, San Diego
- Study coordinator: Idoyaga, Juliana
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
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Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
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Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
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Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.