Gastroparesis data center supporting patient trials and registries
Official title: Continuation of the Scientific Data Research Center (SDRC) of the Gastroparesis Clinical Research Consortium (GpCRC) 4
Funded at Johns Hopkins University · NIH-11158619 · Data updated 2026-11-12
This program runs and coordinates clinical trials and patient registries to test new treatments and collect health and sample data for adults and children with gastroparesis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2006 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,202,853 |
| NIH project number | 5U24DK074008-19 |
| Project ID | NIH-11158619 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults and children who have symptoms or a clinical diagnosis of gastroparesis and are willing to join a trial or registry at a participating center.
✕Less likely to help
People without gastroparesis or those who do not meet trial or registry eligibility criteria are unlikely to receive direct benefit from participating.
What this research studies
From a patient perspective, this center helps hospitals work together to enroll adults and children who have symptoms of gastroparesis into clinical trials and registries. Staff collect medical information, patient-reported symptoms, and biospecimens and manage these data securely across sites. The center will finish ongoing trials (including an adult buspirone trial and a pyloric sphincter study), continue adult and pediatric registries, and design new treatment trials. It also centralizes oversight with a single IRB and provides statistical, data-management, and quality-assurance support to the consortium.
Why it matters
Potential benefit: If successful, the work could speed development of better treatments, improve diagnosis, and guide personalized care for people with gastroparesis.
How similar studies have gone: The Gastroparesis Clinical Research Consortium has produced findings since 2006 that have advanced understanding and care, but new treatment trials remain necessary and their outcomes are not yet known.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Shade, David M — Johns Hopkins University
- Study coordinator: Shade, David M
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
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Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
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Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.