Improving diagnosis and care for gastroparesis and related stomach disorders
Official title: Advancing Science for the Diagnosis and Treatment of Gastroparesis
Funded at Mayo Clinic Arizona · NIH-11161590 · Data updated 2026-11-12
This project will grow a patient registry and test whether the drug pioglitazone can help adults with gastroparesis and related functional dyspepsia.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | April 15, 2006 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $106,479 |
| NIH project number | 5U01DK073983-19 |
| Project ID | NIH-11161590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with diagnosed gastroparesis or persistent functional dyspepsia symptoms (chronic nausea, vomiting, early satiety, postprandial fullness, or related abdominal pain) are the likely candidates.
✕Less likely to help
Children, people without gastroparesis or functional dyspepsia, or individuals with medical contraindications to pioglitazone may not benefit from this project.
What this research studies
From a patient's perspective, the team will finish ongoing clinical studies coordinated by the Gastroparesis Clinical Research Consortium, start a larger gastroparesis registry that includes more people with idiopathic functional dyspepsia, and run a clinical study of pioglitazone to see if it affects immune activity linked to stomach nerve problems. The registry will collect medical information and samples to better understand symptom patterns and disease causes. The pioglitazone work will examine whether calming certain immune cells (macrophages) can improve gastric function and symptoms. Together these efforts aim to speed diagnosis and lead to better, more targeted treatments.
Why it matters
Potential benefit: If successful, this work could lead to clearer diagnoses, new treatment options such as pioglitazone for some patients, and more personalized care plans.
How similar studies have gone: Previous consortium studies have improved understanding of gastroparesis, but using pioglitazone to target macrophage-related damage in humans is relatively novel and not yet proven in large trials.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Pasricha, Pankaj J — Mayo Clinic Arizona
- Study coordinator: Pasricha, Pankaj J
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
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Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
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Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
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Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.