Improving diagnosis and care for gastroparesis and related stomach disorders
Advancing Science for the Diagnosis and Treatment of Gastroparesis
This project will grow a patient registry and test whether the drug pioglitazone can help adults with gastroparesis and related functional dyspepsia.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project ID | NIH-11161590 on NIH RePORTER |
What this research studies
From a patient's perspective, the team will finish ongoing clinical studies coordinated by the Gastroparesis Clinical Research Consortium, start a larger gastroparesis registry that includes more people with idiopathic functional dyspepsia, and run a clinical study of pioglitazone to see if it affects immune activity linked to stomach nerve problems. The registry will collect medical information and samples to better understand symptom patterns and disease causes. The pioglitazone work will examine whether calming certain immune cells (macrophages) can improve gastric function and symptoms. Together these efforts aim to speed diagnosis and lead to better, more targeted treatments.
Who could benefit from this research
Good fit: Adults with diagnosed gastroparesis or persistent functional dyspepsia symptoms (chronic nausea, vomiting, early satiety, postprandial fullness, or related abdominal pain) are the likely candidates.
Not a fit: Children, people without gastroparesis or functional dyspepsia, or individuals with medical contraindications to pioglitazone may not benefit from this project.
Why it matters
Potential benefit: If successful, this work could lead to clearer diagnoses, new treatment options such as pioglitazone for some patients, and more personalized care plans.
How similar studies have performed: Previous consortium studies have improved understanding of gastroparesis, but using pioglitazone to target macrophage-related damage in humans is relatively novel and not yet proven in large trials.
Where this research is happening
Scottsdale, United States
- Mayo Clinic Arizona — Scottsdale, United States (Active)
Researchers
- Principal investigator: Pasricha, Pankaj J — Mayo Clinic Arizona
- Study coordinator: Pasricha, Pankaj J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.