Condition

Achalasia clinical trials and research

• 12Clinical trials
• 4NIH research projects
• 1New in 30 days
• 7Countries

Newest Achalasia clinical trials

All recruiting trials (12)

• Full-thickness vs progressive myotomy in POEM for achalasia

  This trial tests whether a full-thickness myotomy during POEM works better than a partial, progressive approach for people with achalasia, to see which method better relieves symptoms with fewer side effects.

  Recruiting at 2 sites Phase 2 Cairo University · Cairo and 1 other locations · NCT07875686

• Impact of Patient Position on EndoFLIP Measurements in Kids and Young Adults

  This study tests whether EndoFLIP measurements differ when patients are in the supine versus left-side position during the procedure.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07780981

• A registry for adults with esophageal movement and reflux problems.

  This project will collect esophageal function tests (manometry, pH-impedance, FLIP) and clinical data from adults with reflux or swallowing symptoms to see if combining these results helps guide diagnosis and long-term care.

  Recruiting IRCCS San Raffaele · Milan, Lombardy · NCT07506746

• Speedboat UltraSlim™ for POEM in adults with achalasia and other esophageal motility disorders.

  This registry will see if using the Speedboat UltraSlim™ device for POEM is safe and effective for adults with achalasia or other esophageal motility disorders.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT07496840

• Using the SpydrBlade Flex device during POEM for achalasia and EGJ outflow obstruction

  This will test whether using the SpydrBlade Flex device during POEM is safe and effective for adults with achalasia or EGJ outflow obstruction.

  Recruiting at 2 sites Chinese University of Hong Kong · Guayaquil and 1 other locations · NCT07406945

• Indocyanine green fluorescence during laparoscopic Heller–Dor for achalasia

  This study will try using indocyanine green dye during laparoscopic Heller‑Dor in adults with type I or II achalasia to find mucosal leaks during surgery and help guide repairs.

  Recruiting Federico II University · Naples · NCT07181070

• Comparing electrosurgical techniques for treating achalasia

  This study is testing two different electrosurgical techniques during a procedure for achalasia to see which one works better and causes less tissue damage.

  Recruiting Phase 3 Cairo University · Cairo · NCT06189859

• New procedure for treating achalasia to reduce reflux

  This study is testing a new procedure for treating achalasia to see if it can reduce the chance of reflux in adults who have trouble swallowing.

  Recruiting Chinese University of Hong Kong · Baltimore, Maryland and 6 other locations · NCT06042127

• Evaluating the use of endoscopic myotomy for gastrointestinal motility disorders

  This study is testing how well a procedure called endoscopic myotomy works for people with different gastrointestinal motility disorders like achalasia and gastroparesis over several years.

  Recruiting AdventHealth · Orlando, Florida · NCT05905016

• Investigating the role of Varicella zoster virus in achalasia

  This study is testing if a treatment that targets the chickenpox virus can help people with achalasia feel better by improving how food moves from the esophagus to the stomach.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05550194

• Understanding muscle fibrosis in achalasia using new imaging technology

  This study is testing a new imaging method to see how muscle changes in the esophagus relate to achalasia, hoping to find better ways to help patients with this condition.

  Recruiting at 2 sites Phase 4 Emory University · Atlanta, Georgia and 1 other locations · NCT04641702

• Endoscopic Myotomy for Achalasia Treatment

  This study looks at how well a specific procedure called endoscopic myotomy works for treating achalasia in patients who have already had the treatment at Methodist Dallas Medical Center.

  Recruiting Methodist Health System · Dallas, Texas · NCT04640753

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Immune Mechanisms Behind Achalasia

  This grant looks at how the immune system may drive achalasia and scarring in the esophagus, with findings possibly guiding new treatments for patients.

  NIH research Emory University · Atlanta, United States · NIH-11454811

• PRECISION MEDICINE IN ACHALASIA: PREMEDIA

  A patient-centered project to understand and improve treatments for achalasia and related esophageal disorders using precise, tailored approaches.

  NIH research Northwestern University · Chicago, United States · NIH-11416283

• Investigating the role of fibrosis in the lower esophageal sphincter for achalasia patients

  This study is looking at how thickening and scarring of muscle tissue affects swallowing in people with achalasia, and it aims to find new treatment options to help improve their condition.

  NIH research Emory University · Atlanta, United States · NIH-10918083

• Improving treatment for achalasia using a new endoscopic technique

  This study is looking at a new procedure called POEM to see how well it helps people with achalasia, a condition that makes swallowing difficult, and it will compare different techniques to find the best way to improve treatment for patients.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10722321

Related topics

Quick answers

How many Achalasia clinical trials are recruiting right now?

12, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (7 trials), Egypt (2 trials), Italy (2 trials), Hong Kong (2 trials), Ecuador (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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