Novel MRI to see how diabetes affects stomach emptying
Use of novel MRI technology to study pathophysiology diabetic gastroparesis
Advanced MRI is being used to watch how the stomach moves and empties in people with diabetes who have slow stomach emptying.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11181323 on NIH RePORTER |
What this research studies
You would get contrast-enhanced MRI scans that take detailed moving pictures of your stomach while it digests a test meal. Automated image processing will measure fundic accommodation, antral contractions, pyloric opening, and overall emptying so doctors can see which parts of the stomach are not working together. The project compares human scans with animal and computer-model data to better understand the mechanics behind delayed gastric emptying. Results aim to pinpoint specific motor problems that could be targeted by new treatments.
Who could benefit from this research
Good fit: Ideal candidates are adults with diabetes who have symptoms of delayed gastric emptying (nausea, vomiting, bloating, early fullness) or a prior diagnosis of gastroparesis.
Not a fit: People without diabetic-related gastric emptying problems, those with mechanical obstruction of the stomach, or anyone who cannot undergo MRI are unlikely to benefit.
Why it matters
Potential benefit: If successful, this work could improve diagnosis and lead to more targeted treatments for diabetic gastroparesis.
How similar studies have performed: Early pilot studies and animal work using MRI and computational models have shown promise, but applying this integrated imaging and automated analysis in patients is relatively new.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Chen, Jiande — University of Michigan at Ann Arbor
- Study coordinator: Chen, Jiande
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.