Gastroparesis: understanding causes and improving treatments for this stomach-emptying disorder
Official title: U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium
Funded at University of Louisville · NIH-11386523 · Data updated 2026-11-12
A national research effort at University of Louisville is studying why gastroparesis happens and how to treat it, with patients experiencing symptoms like nausea, vomiting, and abdominal pain in mind.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | April 15, 2006 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $349,914 |
| NIH project number | 5U01DK074007-20 |
| Project ID | NIH-11386523 on NIH RePORTER |
Who could benefit from this research
✓Could help
People diagnosed with gastroparesis or those with chronic gastric delay seeking better management options.
✕Less likely to help
Patients not currently experiencing gastroparesis or not eligible for the study may not see direct benefits.
What this research studies
This program brings together clinicians and researchers to explore what drives gastroparesis and how best to manage it. It uses patient data and clinical observations to connect symptoms with underlying biology and to test potential treatments over time. The goal is to improve long-term outcomes and quality of life for people, especially younger women, affected by this condition.
Why it matters
Potential benefit: If successful, the research could lead to better treatments, fewer symptoms, and improved daily functioning for gastroparesis patients.
How similar studies have gone: Previous collaborations within the Gastroparesis Clinical Research Consortium have advanced understanding and management, with ongoing efforts building on earlier findings.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Abell, Thomas Lyman — University of Louisville
- Study coordinator: Abell, Thomas Lyman
Related research
Other NIH-funded projects on the same topics.
-
New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
-
Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.