Exploring subtypes of gastroparesis and related symptoms using physiological tests
Official title: Exploration of Subtypes of Gastroparesis and Gastroparesis-like Symptoms based on Physiological Testing
Funded at Wake Forest University Health Sciences · NIH-11384672 · Data updated 2026-11-12
This grant supports research to better classify gastroparesis and gastroparesis-like symptoms by physiological testing to guide personalized care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | April 15, 2006 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $321,500 |
| NIH project number | 5U01DK073974-20 |
| Project ID | NIH-11384672 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with gastroparesis or gastroparesis-like symptoms who have participated in or could participate in the GPCRC studies and related protocols.
✕Less likely to help
Patients without GP or GP-like symptoms or those not matching the study's specific subtypes or eligibility criteria may not benefit.
What this research studies
If funded, researchers at Wake Forest will continue and expand studies from the Gastroparesis Clinical Research Consortium, using tests of gastric muscle activity, stomach filling responses, and pyloric function to identify subtypes. A new protocol will test whether balloon dilation of the pylorus helps reduce symptoms in gastroparesis and similar conditions. The work builds on existing registries and previous trials to improve diagnosis and tailor treatments for patients with GP or GP-like symptoms, including those with normal gastric emptying. The project aims to clarify disease mechanisms and refine therapeutic approaches for better patient outcomes.
Why it matters
Potential benefit: Better identification of GP subtypes could lead to more targeted and effective treatments for patients.
How similar studies have gone: Previous GPCRC studies and related trials have yielded important insights, with ongoing efforts to refine subtyping and therapies.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Moshiree, Baharak — Wake Forest University Health Sciences
- Study coordinator: Moshiree, Baharak
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
-
Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.