Pediatric and Young Adult Gastroparesis Registry and Disease Course
Official title: The GpCRC Pediatric Gastroparesis Registry 2 (PGpR2): Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants with Symptoms of Gast
Funded at Texas Tech University Health Sciences Center at El Paso · NIH-11575566 · Data updated 2026-11-12
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Sciences Center at El Paso NIH-funded |
| Lab location | 1 site (El Paso, United States) |
| Project start | September 30, 2008 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $61,800 |
| NIH project number | 3U01DK074035-17S1 |
| Project ID | NIH-11575566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and young adults aged 8–25 with symptoms suggestive of gastroparesis who may have delayed gastric emptying or a GLS (gastroparesis-like syndrome).
✕Less likely to help
Participants without these symptoms or those not followed for the full study period may not benefit from the insights gained.
What this research studies
This is an observational, multicenter registry that enrolls participants aged 8–25 with symptoms of gastroparesis, collecting regular data on symptoms, clinical outcomes, and quality of life. It compares those with confirmed delayed gastric emptying to those with similar symptoms but normal emptying to identify distinct disease patterns. Participants are followed for up to three years, with standardized data gathered from medical records, physiological tests, and patient-reported outcomes. Results will help doctors understand the natural history of pediatric and young adult gastroparesis and improve future care. The study emphasizes real-world data rather than an interventional treatment.
Why it matters
Potential benefit: If successful, the findings could clarify how gastroparesis progresses in young people and guide personalized management in the future.
How similar studies have gone: Similar observational registries have helped characterize gastroparesis phenotypes, but this study focuses on a pediatric/young adult population with parallel comparison groups.
Where this research is happening
-
Texas Tech University Health Sciences Center at El Paso
El Paso, United States Active
Researchers
- Principal investigator: Sarosiek, Irene — Texas Tech University Health Sciences Center at El Paso
- Study coordinator: Sarosiek, Irene
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
-
Prucalopride for gastroparesis in adults: a multi-site trial
A multicenter study tests a medicine called prucalopride to help adults with gastroparesis feel better and have fewer stomach symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.