Registry for understanding gastroparesis and related motility disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects biopsy samples from patients diagnosed with gastroparesis who are undergoing gastric electrical stimulation implantation surgery. It also includes a control group of patients without gastroparesis undergoing various digestive surgeries. The study aims to investigate the underlying causes of motility disorders, assess symptom severity through questionnaires, and follow patients over 24 months to evaluate outcomes. The collected data will help direct future investigations and improve prognosis for patients with these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria Study Group:

Patients who are undergoing surgical full-thickness biopsy of the stomach and/or proximal jejunum for the clinical evaluation of GI neuromuscular disorder.

Inclusion Criteria Control Group:

Patients undergoing esophagectomy, sleeve gastrectomy for obesity, or Roux-en Y gastric bypass Patients undergoing Whipple surgery Patients undergoing transplant surgery

Patients who are organ donors and undergoing surgery

Exclusion Criteria Study Group:

Contraindication for surgical full-thickness biopsy for any reason. Significant comorbidity due to severe cardiovascular, renal, pulmonary, or liver disease.

Significant coagulopathy Non-ambulatory patients: bed-ridden, nursing home resident. Pregnant Unable to give own informed consent Prisoners

Exclusion Criteria Control Group:

Prior diagnosis of gastroparesis Prior diagnosis of chronic intestinal pseudo-obstruction Unable to give own informed consent if not an organ donor

Where it's running

• Indiana University Hosptial
  Indianapolis, Indiana, United States Recruiting

Study contacts

• Principal investigator: John M Wo, MD — Indiana University
• Study coordinator: Maureen M Schilling, MD
• Email: maschi@iu.edu

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gastric-focused ultrasound to see if it changes stomach activity and symptoms

  This study tests whether noninvasive stomach-focused ultrasound can alter post-meal stomach electrical activity and symptoms in adults with gastroparesis or delayed gastric emptying, using a sham control in a crossover design.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07851727

• Gastric emptying and feeding tolerance in ICU patients by vasopressor dose

  This study tests whether vasopressor dose affects how well stomach contents empty during tube feeding in critically ill patients.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul · NCT07802379

• Virtual poetry workshops to boost well-being for people with digestive symptoms

  This study tests whether participating in online poetry workshops can improve emotional well-being for adults with chronic digestive symptoms and anxiety or depression.

  Recruiting Ohio State University · Columbus, Ohio · NCT07717541

• Risk prediction for gastric retention during sedated gastroscopy

  This study will test a simple grading system and prediction model to see if clinicians can identify which adults are likely to have significant stomach contents before sedated gastroscopy.

  Recruiting at 2 sites Zhejiang University · Hangzhou, Zhejiang and 2 other locations · NCT07104214

• Prokinetics and Body Surface Gastric Mapping in Dyspeptic Patients

  This study tests whether using Body Surface Gastric Mapping can help predict which medications will help people with gastroparesis or functional dyspepsia see improvement.

  Recruiting at 2 sites University of Auckland, New Zealand · Philadelphia, Pennsylvania and 2 other locations · NCT06854120

• Using Growth Hormone to Treat Gastroparesis

  This study is testing if Growth Hormone can help people with gastroparesis feel better when other treatments haven't worked.

  Recruiting at 2 sites Early Phase 1 Mayo Clinic · Phoenix, Arizona and 1 other locations · NCT06803589

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.