Improving understanding and treatment of gastroparesis at the University of Louisville
Official title: U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium
Funded at University of Louisville · NIH-11158674 · Data updated 2026-11-12
This consortium effort brings clinical experts together to learn more about what causes gastroparesis and to improve care for people with delayed stomach emptying, nausea, vomiting, and related symptoms.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | April 15, 2006 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $342,909 |
| NIH project number | 5U01DK074007-19 |
| Project ID | NIH-11158674 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (especially women) with a diagnosis of gastroparesis or persistent symptoms such as chronic nausea, vomiting, early satiety, or documented delayed gastric emptying would be the main candidates.
✕Less likely to help
People without gastroparesis or with unrelated gastrointestinal conditions, or those unwilling to undergo testing or follow‑up visits, are unlikely to benefit from participation.
What this research studies
If you join, you would work with specialists who follow people with gastroparesis over time to better understand symptoms, test results, and long‑term outcomes. You may have standardized symptom surveys, stomach emptying tests, and other clinical measurements, and you might be asked to give biological samples for research. The program coordinates multiple centers to compare patients by cause, severity, and test findings and may offer access to clinical treatment options or trials. The goal is to make care less trial‑and‑error and to develop clearer, more effective treatment approaches.
Why it matters
Potential benefit: Better understanding of causes and disease course could lead to more effective, targeted treatments and clearer guidance on nutrition and long‑term outcomes.
How similar studies have gone: Previous work from the Gastroparesis Clinical Research Consortium has improved knowledge and led to some treatment advances, but many therapies remain only partially effective and more study is needed.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Abell, Thomas Lyman — University of Louisville
- Study coordinator: Abell, Thomas Lyman
Related research
Other NIH-funded projects on the same topics.
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New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
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Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
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Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.