Temple University Gastroparesis Clinical Center
Funded at Temple Univ of the Commonwealth · NIH-11171447 · Data updated 2026-11-12
This program follows people with gastroparesis to learn what causes symptoms, to look at immune and pyloric muscle changes, and to try treatments such as buspirone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 15, 2006 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $182,546 |
| NIH project number | 5U01DK073975-19 |
| Project ID | NIH-11171447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a diagnosis of gastroparesis who can attend clinic visits and agree to the required tests and follow‑up are the ideal candidates.
✕Less likely to help
People without gastroparesis, those unable to travel to the clinic, or those who cannot undergo required tests or biopsies are unlikely to gain direct benefit from participating.
What this research studies
You can join the Gastroparesis Registry where Temple will enroll up to 400 people and follow them for 1–4 years to track symptoms, tests, and outcomes. The center runs ongoing projects including a clinical trial of buspirone for early satiety (BESST), a pathology study examining immune cell patterns in stomach tissue (PBG), and a new study of pyloric sphincter function. GpR3 has been expanded to collect information about how prior SARS‑CoV‑2 (COVID‑19) infection affects people with gastroparesis. Joining may involve clinic visits, questionnaires, medical testing, and in some studies a tissue biopsy.
Why it matters
Potential benefit: If successful, this work could lead to better symptom relief, more targeted treatments, and clearer explanations of why gastroparesis happens.
How similar studies have gone: Past gastroparesis registries and clinical trials have improved understanding of symptoms and found some promising therapies, but many questions remain and elements like immune profiling and COVID‑19 effects are relatively new.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Parkman, Henry Paul — Temple Univ of the Commonwealth
- Study coordinator: Parkman, Henry Paul
Related research
Other NIH-funded projects on the same topics.
-
New England Gastroparesis Consortium: Neurobiology of Gastroparesis
A national project to learn about gastroparesis in children and adults by creating a registry and gathering information from patients to understand symptoms, quality of life, and disease progression.
-
Pediatric and Young Adult Gastroparesis Registry and Disease Course
This project follows children, teens, and young adults with symptoms of gastroparesis to learn how their symptoms change over time and what factors are tied to different disease patterns.
-
Pediatric gastroparesis: building a nationwide patient registry
This grant funds a national registry to study gastroparesis and similar tummy problems in children and teens, with the goal of better understanding how the condition affects their daily lives.
-
Gut-resident macrophages and gastric function in gastroparesis
A study in people with gastroparesis to understand how gut macrophages affect stomach movement and gut barrier health, with the hope of finding new ways to treat the condition.
-
Gastric electrical stimulation for stomach pain in gastroparesis
A new approach tests how adjusting a stomach-stimulating implant may reduce pain for people with gastroparesis.
-
Peptide therapies for gastroparesis in diabetes
A new peptide-based treatment is being tested to help people with gastroparesis linked to diabetes by improving stomach emptying and reducing inflammation.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.