Sponsor or institution
Clinical trials and research at Wake Forest University Health Sciences
As of November 12, 2026, Find a Trial lists 147 clinical trials run by Wake Forest University Health Sciences that are recruiting, at sites in 4 countries (most in United States (146), Australia (2), Puerto Rico (1)). By phase: Phase 2 (15), Phase 4 (10), Phase 3 (8), Phase 1 (4). There are also 522 NIH-funded research projects at this institution, with $329.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 147Clinical trials
- 522NIH research projects
- 4Countries
Newest trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Cognitive changes after BCMA CAR-T in multiple myeloma | — | Charlotte, North Carolina | Recruiting | Jul 31, 2026 |
| Pelashield vs Xeroform for donor-site dressings in skin graft patients | Phase 4 | Winston-Salem, North Carolina | Recruiting | Jul 29, 2026 |
| Optimizing how patients get blood pressure cuffs and how they log readings in primary care | — | Chicago, Illinois and 5 other locations | Recruiting | Jul 9, 2026 |
| Two hospital-to-home transition programs for older adults and their family caregivers | — | Bermuda Run, North Carolina and 3 other locations | Recruiting | Jun 22, 2026 |
| How well stroke patients move early after a severe stroke using a wearable | — | Winston-Salem, North Carolina | Recruiting | Jun 10, 2026 |
| LP-118 in combination with standard therapy for newly diagnosed Ph+ ALL | Phase 1 | Charlotte, North Carolina and 1 other locations | Recruiting | May 29, 2026 |
| Higher methotrexate discharge after standard osteosarcoma chemo | Phase 2 | Chapel Hill, North Carolina and 8 other locations | Recruiting | May 1, 2026 |
| Head-frame pain relief: Suzetrigine vs. acetaminophen for adults | Phase 3 | Winston-Salem, North Carolina | Recruiting | Apr 13, 2026 |
| Personalized Exercise Plan for Breast Cancer Survivors on Chemotherapy | — | Winston-Salem, North Carolina and 3 other locations | Recruiting | Mar 16, 2026 |
| Boosted exercise with group coaching for HFpEF | — | Winston-Salem, North Carolina | Recruiting | Feb 17, 2026 |
All recruiting trials (147)
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Cognitive changes after BCMA CAR-T in multiple myeloma
This study tests whether cognitive function changes over time in adults with relapsed or refractory multiple myeloma who receive BCMA CAR-T therapy.
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Pelashield vs Xeroform for donor-site dressings in skin graft patients
A randomized, patient-treated trial tests whether Pelashield, a new skin graft dressing, can better control pain and improve donor-site appearance compared with the standard Xeroform in split-thickness skin grafts.
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Optimizing how patients get blood pressure cuffs and how they log readings in primary care
We’re testing the best way to provide a standard, validated blood pressure cuff and the easiest way for patients to log their readings in routine primary care among adults with uncontrolled hypertension.
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Two hospital-to-home transition programs for older adults and their family caregivers
Aims to see if adding family support to a patient-focused discharge plan helps older adults stay at home safely and reduces ER visits or hospital readmissions.
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How well stroke patients move early after a severe stroke using a wearable
This study tests how adults with severe acute ischemic stroke move during their hospital stay by wearing a small activity monitor to see early mobility patterns.
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LP-118 in combination with standard therapy for newly diagnosed Ph+ ALL
This study tests whether adding LP-118 to the standard therapy for adults with Philadelphia chromosome–positive ALL is safe and useful.
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Higher methotrexate discharge after standard osteosarcoma chemo
In newly diagnosed osteosarcoma patients 22 or younger, this study tests whether they can go home earlier with higher methotrexate levels after standard HD-MTX-based chemotherapy.
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Head-frame pain relief: Suzetrigine vs. acetaminophen for adults
This study tests whether Suzetrigine or acetaminophen better reduces pain during stereotactic head frame placement in adults.
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Personalized Exercise Plan for Breast Cancer Survivors on Chemotherapy
This trial tests whether adding a guided exercise program to a healthy-lifestyle education plan helps breast cancer patients undergoing chemotherapy maintain fitness, heart health, and quality of life.
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Boosted exercise with group coaching for HFpEF
This trial tests a blended, guided exercise program with group coaching and remote monitoring to see if it helps older adults with HFpEF improve activity and health at a lower cost.
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Intravenous oxytocin to change how skin nerves respond to heat and touch
This study will test whether a single IV dose of oxytocin can reduce localized heat-induced pain and change how peripheral nerves respond in healthy adults aged 18–65.
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Peripheral Venous Pressure–Guided Care in Heart Failure
In people with congestive heart failure, this study tests whether daily peripheral venous pressure measurements, used to guide treatment, can shorten hospital stays and reduce readmissions compared with standard care.
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Walk On! community walking program for older adults with mobility limits
This program tests whether a 12-week, twice-weekly group walking program can help prevent falls and reduce loneliness in older adults who have trouble moving around or feel isolated.
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Quantitative MRI measurement of muscle changes in myotonic dystrophy
This project will test whether advanced quantitative MRI scans can measure muscle structure and link to disease severity and RNA changes in adults with myotonic dystrophy.
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Culturally tailored food bundles and nutrition support for adults with food insecurity and diabetes
This program will try culturally familiar food bundles and easy recipes to help adults with type 2 diabetes who have trouble affording healthy food.
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Telehealth and remote blood pressure management for pregnant women with chronic high blood pressure
This study tests whether alternating telehealth visits with home blood pressure monitoring and health coaching helps pregnant women (18–45) with chronic high blood pressure compared with standard in-person care.
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Virtual reality to reduce anxiety during radiation therapy
This study will try using VR during radiation sessions to see if it reduces anxiety for adults receiving radiation for prostate, breast, lung, or head and neck cancer.
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Mobile patient health technology to increase lung cancer screening in high‑risk adults
This project will test whether a mobile health tool combined with portal and text message outreach increases lung cancer screening among high‑risk adults eligible under current Medicare criteria.
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Metformin plus standard first-line therapy for advanced soft tissue sarcoma
This trial tests whether adding metformin to standard first-line systemic treatment helps people with previously untreated advanced or metastatic soft tissue sarcoma.
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Community support program to address families' social needs during childhood cancer care
This project will try a community-designed support program (CERCA) to help families of children with cancer get services for unmet social needs.
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Two ways to fix distal femur fractures in older adults
This trial tests whether a single implant or two implants help older adults with distal femur fractures return to work and daily activities sooner.
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Weekly self-monitoring feedback and goal prompts to support weight loss
This trial will test different weekly feedback messages and goal prompts delivered by smartphone to see which help adults with overweight or obesity stick to tracking their diet, activity, and weight and lose more weight.
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Flexible bandage-style conductive hearing aid for conductive hearing loss
This study will test a flexible, Band-Aid–like conductive hearing aid for children and adults with permanent conductive or mixed hearing loss to see if it improves comfort and hearing without surgery.
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Tracking frailty and thinking before and after pre-surgery chemotherapy for advanced ovarian and endometrial cancer
This study will see if an automated frailty score and brief thinking tests change after 3–4 cycles of neoadjuvant (pre-surgery) chemotherapy in people over 55 with advanced ovarian or endometrial cancer.
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Does emptying the stomach improve TEE heart images?
This will see if suctioning stomach contents during heart surgery improves the clarity of transesophageal echocardiography (TEE) images for patients having TEE-guided cardiac operations.
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Virtual reality headsets to reduce pain and anxiety during bone marrow biopsy
This will try a virtual reality headset to see if it reduces pain and anxiety for adults having an outpatient bone marrow biopsy or aspiration.
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Comprehensive care needs for adolescents and young adults with cancer
See what education and support gaps adolescents and young adults with cancer have around exercise, sexual health, fertility, survivorship, finances, relationships, and clinical trials.
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Boosting resilience with an electronic frailty index guided care plan
This program sees if using an electronic frailty index to guide tailored supportive care and weekly symptom check-ins helps people 65 and older stay resilient while receiving chemotherapy.
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Enhancing Deep Sleep in Depression with Non-Invasive Brain Stimulation
This pilot test will try non-invasive brain stimulation during sleep to see if it increases deep sleep and improves mood and thinking in adults with major depressive disorder.
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Standardized bedside feeding checks using the SMART Tool
This project will test whether using the SMART Tool for premature and medically complex infants in the NICU improves feeding safety and shortens hospital stays.
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Phone conversations with EMS physicians to reduce ambulance transport refusals
This will test whether adult patients who speak by phone with an EMS physician are less likely to refuse ambulance transport after a 911 call than those who do not.
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R.E.C.K versus Exparel for pain control during robotic kidney removal
This will test whether intraoperative R.E.C.K or Exparel gives better pain control and reduces opioid use in adults having robotic partial or radical nephrectomy.
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How mitochondrial function relates to resilience in ovarian and endometrial cancer
This pilot tries whether people 50 and older with advanced ovarian or endometrial cancer will complete physical and cognitive tests plus blood and muscle sampling before and after treatment to see if mitochondrial function links to resilience.
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Skin image reference tool to help doctors diagnose skin conditions
This project will test whether Belle.ai can use three de-identified photos to help dermatologists at an Advocate Health clinic pick the right diagnosis for common skin conditions.
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Adaptive program to reduce food insecurity for people with uncontrolled high blood pressure
This study will test whether different food-support approaches—resource information, community health worker help, or medically-tailored meals—help adults with uncontrolled hypertension who face food insecurity stick to diet and medication plans and lower their blood pressure.
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Meals and grocery support for families of hospitalized children
This project tests whether giving prepared family meals or grocery gift cards to caregivers of hospitalized children who screen positive for food insecurity can reduce household food insecurity and improve post-discharge outcomes.
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Mobile app support for young women with breast cancer
This project will test whether the Mighty Pro mobile app can help lower cancer-related distress in women aged 18–45 with breast cancer.
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Vibegron for energy, thinking, and resilience in obesity in older adults
This 12-week study tests whether Vibegron can boost energy metabolism, heart and metabolic health, and physical and cognitive function in adults aged 45–75 with obesity.
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Liquid biopsy (ctDNA) blood test for bone and soft tissue sarcoma
This study will test whether low-pass whole genome sequencing of a blood liquid biopsy can detect tumor DNA in adults and children with bone or soft tissue sarcomas.
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Systematic financial navigation for adults with acute myeloid leukemia
This program will test whether adding systematic financial navigation to usual support helps adults 18–64 with acute myeloid leukemia lower financial stress and improve quality of life.
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Functional knee bracing after quadriceps ACL reconstruction
This trial will test whether wearing a functional knee brace after quadriceps-tendon ACL reconstruction helps young athletes and military personnel return to sport and reduces graft failures over two years.
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Adaptive program to improve food access and maternal and child health during pregnancy
This pilot will test whether giving food-insecure pregnant people different supports—like WIC referrals, produce prescriptions, or medically tailored meals—based on their needs helps improve food access and health.
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Comparison of urinary flow with two female intermittent catheters
This test will see if two different female intermittent catheters produce different urinary flow speeds in adults who regularly catheterize.
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Evaluating a new device for securing surgical drains to improve patient outcomes
This study is testing a new device called K-LOCK™ to see if it can better secure surgical drains and improve recovery for patients after surgery.
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COACH-APP: education and mentorship to help advanced practice providers join community oncology clinical teams
This program will test whether focused education and structured mentorship helps nurse practitioners and physician assistants in community oncology feel more confident taking part in clinical research.
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Magnesium plus prochlorperazine for migraine relief
This trial will test whether adding IV magnesium to IV prochlorperazine helps adults with migraine get better pain relief in the emergency department.
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Better quality-of-life questions for adolescents and young adults with cancer
This project will test how adolescents and young adults with cancer (ages 15–39) and their caregivers in the U.S. answer quality-of-life questions so the questions can be improved.
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Quitting Matters: a smoking quit program for people living with HIV
This 6-month program will test whether a tailored smartphone app plus nicotine patches and gum helps people living with HIV quit smoking better than a standard quit app.
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Continuous belly pressure monitoring during pulsed field ablation for atrial fibrillation/flutter
This will test whether using an Accuryn Foley catheter to continuously measure intra-abdominal pressure during pulsed field ablation can reveal pressure changes related to different types of anesthesia in adults treated for atrial fibrillation or atrial flutter.
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Single versus Dual Perclose Device Closure for Large-Bore Femoral Access in TAVR
This will test whether using one Perclose device instead of two closes large-bore femoral access faster and with similar or fewer complications in people having transfemoral TAVR.
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Evaluating the risk of blood cancers in firefighters
This study is testing if firefighters who have been exposed to harmful substances are at a higher risk for blood cancers and related conditions.
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Low-dose aspirin to prevent venous blood clots during chemotherapy for advanced germ cell (testicular) cancer
This trial will see if taking one daily low-dose aspirin (81 mg) during cisplatin chemotherapy prevents venous blood clots over six months in adults up to age 70 with high-risk advanced germ cell or testicular cancer.
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Preventing seizures in traumatic brain injury using two medications
This study tests which of two medications, levetiracetam or lacosamide, is better at preventing seizures in people with moderate to severe traumatic brain injuries.
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Test with Dexcom G7 glucose monitor during heart surgery
Researchers will see if the Dexcom G7 continuous glucose monitor accurately reflects blood sugar during cardiopulmonary bypass and in the ICU after heart surgery in adults.
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Fisetin for fatigue in older cancer survivors
This will see if taking fisetin pills in short dosing periods reduces fatigue in cancer survivors aged 65 and older.
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Understanding how chronic stress affects brain and immune function in HIV positive individuals using stimulants
This study is testing how chronic stress affects the brain and immune system in people with HIV who use stimulants, to see if a new online program can help improve their health.
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Using 3D-printed mouth splints to improve oral function
This study is testing if custom 3D-printed mouth splints can help people with small mouths from burn injuries eat and speak better while making their daily lives easier.
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Evaluating opioid use after surgery in genitourinary cancer patients
This study looks at how much pain medicine people use after surgery for genitourinary cancers and whether they are happy with their care, while also teaching them how to safely get rid of leftover medicine.
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Bump the Lump: a speech-language therapy program for persistent throat lump sensations
This project will try a standardized speech-language therapy program to see if it reduces the persistent lump or tightness in the throat in adults with globus pharyngeus.
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Improving physical function in older adults with advanced chronic kidney disease
We will try a 12-week high-velocity resistance training program to see if it safely improves muscle power and physical function in mobility-limited older adults with advanced chronic kidney disease.
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Telehealth support for caregivers of cancer patients
This study tests if a telehealth support program can help caregivers of cancer patients feel less stressed about money and depression while improving their confidence and satisfaction in caring for their loved ones.
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Using cranial ultrasound to detect brain injuries in children
This study is testing if a special type of ultrasound can help doctors find serious brain injuries in children with head trauma without using radiation.
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Evaluation of a postpartum education and support program for rural women
This study is testing a new support program for new moms in rural North Carolina to see if it helps them stay healthier and reduces hospital visits compared to regular care.
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Assessing and managing taste changes in cancer patients undergoing chemotherapy
This study is testing if a special program led by nurses can help cancer patients undergoing chemotherapy better manage changes in their taste and feel more in control of their symptoms.
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Identifying precancerous multiple myeloma in African American adults
This study is testing a way to find early signs of multiple myeloma in Black and African American adults aged 30 and older to help catch it sooner and improve their health outcomes.
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Understanding cancer-related fatigue in survivors
This study looks at how cancer-related fatigue affects survivors and how they talk about it with their doctors to help improve communication and support.
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Program to reduce concussions and head impacts in youth football
This study is testing a new safety program for youth football coaches to see if it can help reduce concussions and head impacts for young players.
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Comparing accelerated and standard radiotherapy for head and neck cancer after surgery
This study is testing whether getting six radiation treatments a week instead of five can help patients with head and neck cancer who are starting treatment after surgery feel better and live longer.
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Genetic factors affecting treatment response in acute myeloid leukemia
This study is testing how certain genetic differences affect the side effects and success of a treatment for people newly diagnosed with acute myeloid leukemia who are receiving azacitidine and venetoclax.
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Understanding cancer-related fatigue in lung cancer patients on immunotherapy
This study is trying to understand how cancer-related fatigue affects people with lung cancer who are receiving immunotherapy and what their caregivers experience during this time.
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Managing high blood pressure in Black patients remotely
This study tests whether managing high blood pressure at home with help from a pharmacist and a community health worker works better than regular clinic care for Black patients with uncontrolled hypertension.
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Cardiovascular risk assessment for patients with lipid disorders in emergency care
This study is testing a new way to help emergency room patients with high cholesterol lower their heart disease risk by providing better care compared to the usual treatment.
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Understanding the risks of thrombosis in CALR-mutated MPN patients
This study is trying to understand why people with CALR mutations in myeloproliferative neoplasms have a different risk of blood clots compared to those with JAK2 mutations by looking at certain blood markers.
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Examining the effects of cannabis use in cancer patients undergoing treatment
This study is trying to see how using cannabis affects newly diagnosed cancer patients who are starting treatment for their illness.
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Improving the appearance of cesarean section scars
This study is testing two different ways to close the skin after a cesarean delivery to see which one makes the scar look better.
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Comparing different doses of magnesium for treating rapid atrial fibrillation
This study is testing whether different doses of magnesium can help people with rapid atrial fibrillation feel better compared to a placebo.
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Optimizing bowel habits after pelvic surgery
This study tests whether taking oral senna or using rectal bisacodyl suppositories can help women who have had vaginal surgery for pelvic organ prolapse avoid constipation after their surgery.
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Comparing single and dual implant methods for fixing distal femur fractures
This study is testing whether using one or two implants to fix certain types of thigh bone fractures helps patients heal better and get back to their daily activities faster.
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Surgical options for treating severe heel fractures
This study is testing two different surgical methods for treating severe heel fractures to see which one helps patients get back to work faster.
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Topical treatment for atopic dermatitis
This study is testing if teaching patients the right way to use a cream for atopic dermatitis can help them stick to their treatment better and improve their skin condition.
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Comparing microneedling and dermabrasion for treating facial scars
This study tests whether microneedling or dermabrasion works better to improve the look of new surgical scars on the face for adults.
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Exercise program for patients with cardiac amyloidosis
This study tests whether a supervised exercise program can help people with cardiac amyloidosis and heart failure feel better and improve their heart health.
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Virtual wellness program for migraine management
This study tests two online wellness programs to see if they can help people with migraines feel better while they continue their usual medications.
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Screening and treating depression in orthopedic trauma patients
This pilot will test whether screening orthopedic trauma patients for depression and offering fluoxetine or duloxetine improves depressive symptoms and recovery compared with choosing no medication.
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Preventing knee osteoarthritis through diet and exercise in obese women over 50
This study is testing if a weight loss diet and exercise can help prevent knee osteoarthritis in obese women over 50 who don’t have much knee pain.
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Evaluating outpatient care versus hospitalization for patients with chest pain
This study is testing whether a quick outpatient care plan for patients with moderate chest pain is better than being hospitalized for treatment.
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Multisensory Training to Help Hemianopia After Stroke
We’re testing a multisensory training approach to see if it can improve vision in people with homonymous hemianopia after a stroke, comparing long-standing cases to those treated soon after the stroke.
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Inhaled nitric oxide during mechanical clot removal for acute ischemic stroke
This test gives inhaled nitric oxide during mechanical clot removal to adults with acute ischemic stroke to see if it is safe and can help protect vulnerable brain tissue.
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Identifying challenges to healthy aging in older adults with HIV
This study is trying to understand frailty in older adults with HIV and see if personalized activity and nutrition plans can help improve their health.
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Using antidepressants to prevent depression after fragility fractures in older adults
This study is testing if giving antidepressants to older adults with leg fractures when they leave the hospital can help prevent depression.
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Evaluating anesthesia methods in young patients
This study is testing how different anesthesia methods affect young patients' breathing and recovery after surgery to find the best ways to safely wake them up.
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Comparing Incremental Hemodialysis to Conventional Hemodialysis
This study is testing if a new way of doing hemodialysis called incremental hemodialysis can help people with end-stage kidney disease feel better and have fewer hospital visits compared to the standard method.
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Chemotherapy sequence for pancreatic cancer treatment
This study is testing a new order of chemotherapy drugs to see if it helps people with hard-to-treat pancreatic cancer have their tumors completely removed through surgery.
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A program to help rural smokers who aren't ready to quit
This study is testing a new program to help rural adults who smoke but aren't ready to quit by providing them with support and resources through mobile health technology and community paramedics.
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Using a custom orthotic and rehabilitation program for lower limb injuries
This study is testing if using a special orthotic along with a focused rehab program can help people with lower limb injuries recover better and improve their performance.
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Using an antibiotic depot to prevent infections in open tibia fractures
This study is testing if a new antibiotic treatment can help prevent infections in people with open tibia fractures compared to standard care.
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Combining exercise and medication to reduce bone loss during weight loss in older adults
This study is testing if combining exercise and medication can help older adults lose weight without losing bone strength.
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Improving oral hygiene to reduce risk of infective endocarditis
This study tests if better oral hygiene, through dental cleaning and education, can help reduce bacteria in the blood for people at risk of infective endocarditis.
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Effects of very low nicotine cigarettes on heart health
This study is testing how smoking very low nicotine cigarettes affects heart health in both daily and occasional smokers.
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Quick start of Durvalumab after chemotherapy and radiation for advanced lung cancer
This study is testing if starting Durvalumab treatment right after chemotherapy and radiation can help people with advanced lung cancer feel better and improve their outcomes.
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Monitoring the brain with MRI to detect cancer spread early
This study is testing if regular brain MRI scans after radiation therapy can help catch cancer spread in patients with advanced lung cancer before they start showing symptoms.
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Implanting a tissue-engineered vagina for women with vaginal aplasia
This study is testing a new way to create and implant a tissue-engineered vagina for women who were born without one, to help restore normal vaginal function.
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Program to reduce obesity and diabetes risks in women planning pregnancy
This study tests a special online program to help young women who are overweight or obese lower their diabetes and obesity risks before getting pregnant.
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Rehabilitation for older patients with heart failure
This study is testing a new physical rehabilitation program for older patients with heart failure to see if it helps them stay out of the hospital and improves their mobility.
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Effects of Physical Therapy on Wound Healing in Spinal Cord Injury Patients
This study is testing whether different types of physical therapy can help improve wound healing in people with spinal cord injuries.
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Using coconut oil mouth rinse to prevent mouth sores in kids undergoing chemotherapy
This study is testing if using a mouth rinse made from coconut oil can help prevent mouth sores in kids and young adults undergoing chemotherapy.
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Using antibiotic-coated nails to prevent infections in severe tibia fractures
This study is testing whether using antibiotic-coated nails can help prevent infections in adults with severe tibia fractures compared to regular nails.
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Using cryoablation to improve pain control after rib fracture surgery
This study is testing if using cryoablation on certain nerves after rib fracture surgery can help patients feel less pain and use fewer pain medications.
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Injections of muscle fiber fragments to treat fecal incontinence
This study is testing if injecting muscle fiber fragments can help people with fecal incontinence by improving the strength and function of their anal sphincter muscle.
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Exploring genetic factors linked to cancer cachexia in pancreatic cancer patients
This study is trying to see if certain genetic factors are linked to weight loss and muscle wasting in patients with advanced pancreatic cancer.
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Predicting brain function changes in high-grade glioma patients after radiation
This study is trying to see if brain scans and blood tests can help predict how radiation treatment affects brain function and memory in patients with high-grade glioma.
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Improving health for dementia caregivers using Cereset
This study is testing if a new treatment called Cereset can help caregivers of people with dementia feel less stressed, anxious, and improve their sleep.
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Using advanced sequencing to improve treatment for urinary tract infections
This study is testing if new lab techniques can help women with urinary tract infections get better antibiotic treatment, especially when their urine tests show low levels of bacteria.
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PEMF therapy for women with bladder pain syndrome
This study is testing if a new non-invasive treatment using pulsed electromagnetic fields can help women with bladder pain syndrome feel less pain and improve their urinary symptoms.
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Exercise program for children and young adults with cancer
This study tests if a structured exercise program can help children and young adults with cancer feel better physically and emotionally while they are undergoing treatment.
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Evaluating immune response to vaccines in pediatric cancer survivors
This study tests how well booster vaccines or full revaccination help improve the immune response in kids who have survived cancer compared to their healthy siblings.
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Addressing food insecurities in people living with HIV
This study is testing a new program to see if it can help people living with HIV who struggle with food insecurity improve their health and manage diabetes better.
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Using risedronate to prevent bone loss after bariatric surgery
This study is testing if the medication risedronate can help prevent bone and muscle loss in people who have had bariatric surgery.
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Evaluating Xeomin® for improving mobility after stroke
This study is testing if Xeomin® injections can help improve walking and movement in adults who have weakness on one side after a stroke.
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Using low-dose clonidine to treat PTSD in veterans
This study is testing if a low dose of clonidine can help veterans with PTSD feel better and improve their sleep and daily activities.
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Combination treatment for multiple myeloma using new and standard drugs
This study is testing a new combination of treatments for multiple myeloma to see if it can help newly diagnosed, high-risk patients feel better and improve their outcomes.
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Examining how chronic marijuana use affects inflammation and brain injury in HIV patients
This study is testing how long-term marijuana use affects inflammation and brain health in people living with HIV.
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Using a special LED cap to treat a type of hair loss in women
This study is testing if a special LED cap can help middle-aged women with a type of hair loss called Central Centrifugal Cicatricial Alopecia by stopping hair loss and possibly encouraging regrowth.
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Understanding pediatric hypertension and its effects on the body
This study looks at how different factors related to blood pressure affect children aged 7-18 who have just been diagnosed with high blood pressure, to see how it impacts their health over two years.
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Using aloe vera capsules to manage symptoms of interstitial cystitis
This study is testing if taking aloe vera capsules can help people with interstitial cystitis feel less bladder pain and urinary frequency.
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Vitamin D supplementation for patients with triple negative breast cancer
This study is testing if giving vitamin D to patients with triple negative breast cancer who are low in vitamin D can help them respond better to chemotherapy compared to those who have enough vitamin D.
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Observing recovery in patients with pelvic and acetabular fractures
This study looks at how different treatments for pelvic and acetabular fractures affect recovery and quality of life for patients over time.
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Mobile low-dose CT screening for lung cancer in younger adults
This study is testing if a mobile low-dose CT scan can help find lung cancer earlier in younger adults aged 40-54 who have a significant history of smoking.
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Training healthcare providers on cervical exams during labor and delivery
This study is testing whether training healthcare providers with a special simulator can make cervical exams during labor more accurate and consistent for expectant mothers.
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Cetuximab treatment for advanced head and neck cancer after immunotherapy
This study is testing if the drug Cetuximab can help people with advanced head and neck cancer who didn’t respond to or couldn’t tolerate previous immunotherapy treatments.
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Using omeprazole to enhance treatment for advanced prostate cancer
This study is testing if adding omeprazole to taxane treatments can help men with advanced prostate cancer who haven't responded to these therapies before.
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Using round spermatids to help infertile couples conceive
This study is testing a new way to help couples with male infertility by using special cells called round spermatids to see if they can successfully fertilize eggs and lead to pregnancy.
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Comparing treatment outcomes in lung cancer patients with different performance statuses
This study is testing if immunotherapy treatments can help lung cancer patients with lower performance status feel better and live longer compared to those with better performance status.
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Comparing treatments for hair loss in African-American women
This study is testing two different treatment combinations for hair loss in African-American women with Central Centrifugal Cicatricial Alopecia to see which one works better.
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Examining the effects of low muscle mass on chemotherapy toxicity in older adults with colorectal cancer
This study looks at how having low muscle mass affects the side effects of chemotherapy in older adults with advanced colorectal cancer to see if it impacts their survival.
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Measuring normal pressures in brain veins during angiograms
This study is trying to measure normal pressure in the brain's veins during angiograms to help doctors better understand how pressure works in the brain.
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Exploring Cereset for improving stress and anxiety symptoms
This study is testing whether a new treatment called Cereset can help people aged 11 and older who are dealing with stress, anxiety, or insomnia feel better by using sounds that match their brainwaves.
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Using muscle fiber fragments to enhance rotator cuff recovery
This study is testing whether injecting muscle fiber fragments from the chest into the shoulder can help people recover better and regain strength after rotator cuff surgery.
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Using laser therapy to treat pain and promote healing in chronic venous leg ulcers
This study is testing if laser therapy can help relieve pain and speed up healing for people with chronic venous leg ulcers.
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Examining factors that affect the effectiveness of post-transplant cyclophosphamide
This study is trying to see how genetic factors and drug levels affect the success of a treatment called post-transplant cyclophosphamide in patients who have had a stem cell transplant.
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Using engineered urethral constructs to treat urethral strictures in men
This study is testing a new way to treat urethral strictures in men by using specially grown tissue from their own bladder to see if it helps them feel better over time.
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Observational study on Alzheimer's disease and cognitive impairment
This study is trying to gather important information and samples from adults aged 55 and older, with or without memory problems, to help improve early detection and treatment of Alzheimer's disease.
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Evaluating high-dose methotrexate for breast cancer with leptomeningeal metastasis
This study is testing if high-dose methotrexate can help breast cancer patients with leptomeningeal disease feel better and improve their treatment options.
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Treatment for urinary incontinence using muscle fiber fragments
This study is testing if using muscle fibers from women's thighs can help improve bladder control for those dealing with urinary incontinence.
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Collecting and reporting data on patients receiving stem cell transplants
This study is trying to gather and share information about patients getting stem cell transplants for blood cancers to better understand how well these treatments work.
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Using facial analysis to predict intubation difficulty
This study is testing a computer program that uses pictures of patients' faces to see if it can predict how easy or hard it will be to insert a breathing tube.
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Collecting and storing tissue samples from patients with suspected solid tumors
This study is collecting blood and tissue samples from patients with suspected solid tumors to help with future cancer research and understand how normal tissue changes to cancerous tissue.
NIH-funded research (newest 40 of 522)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Evaluating a combined approach to manage chronic pain
This study is looking at whether taking duloxetine along with online therapy can help people with chronic pain feel better, and it includes some support to help you stick with the therapy; you'll be randomly placed in one of three groups to see which approach works best over six months.
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Drd3 gene variants and cocaine seeking in rats
A study in rats will map different Drd3 gene variants to how cocaine-seeking and taking behavior is influenced, aiming to uncover targets for treating cocaine use disorder.
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Intensive dental care during cancer follow-up to protect teeth after head and neck radiation
A program delivered in oncology clinics to provide fluoride varnish and dental follow-up aims to reduce tooth decay and improve oral health and quality of life for head and neck cancer patients after radiation therapy.
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Wake Forest NCORP Cancer Center Research Base
A patient-focused opportunity to advance real-world cancer care through community-based studies that address how cancer and its treatments affect daily life and well-being.
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Hybrid approach to peer-supported mood and incentive program to reduce HIV risk among women who inject drugs
A pilot program tests a combined peer-supported mood-boosting approach with contingency management to help stimulant-using women who inject drugs reduce HIV risk.
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Coordinating Center for the MoTrPAC project
A large nationwide effort seeks to map how physical activity changes the body at the molecular level, with a coordinating center that handles data, biospecimens, and collaboration across sites.
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HeartShare HFpEF Clinical Center at Wake Forest
A large, patient-centered program at Wake Forest to deeply profile people with HFpEF and healthy controls to uncover new disease mechanisms and treatment targets.
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Genomic clues for early-onset Alzheimer’s disease beyond known genes
A large study will look for new genetic factors behind early-onset Alzheimer’s disease in people without the common APP, PSEN1, or PSEN2 mutations.
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Toward a cure for Hepatitis B using DNA-targeting PNAs
Aims to develop a new, liver-targeted therapy that could remove persistent HBV DNA from liver cells to potentially cure infection.
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Understanding why guideline-concordant endometrial cancer treatment varies in high-risk groups
This project looks at why some patients with endometrial cancer don’t receive care that follows national guidelines, aiming to find ways to ensure more patients get the best-supported treatments.
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Pathway to youth-onset type 2 diabetes: understanding puberty-driven risk
A longitudinal study following high-risk youths through puberty to better understand how puberty affects the development and complications of youth-onset type 2 diabetes.
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Cancer community outreach and engagement in the Wake Forest region
This program connects people across a 30-county Wake Forest area to cancer screenings, education, and opportunities to help shape research.
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How the GSK3α enzyme affects Alzheimer's disease
Researchers are testing whether targeting a specific brain enzyme called GSK3α can reduce the brain changes and memory problems linked to Alzheimer's disease.
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Sleep and mood links in Fragile X Syndrome
A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.
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Assessing real-world effects of a low nicotine standard on smoked tobacco in New Zealand
This study follows adults who smoke daily to see how a policy that lowers nicotine in all smoked tobacco products could change their smoking behavior and health in real life.
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Impact of a low nicotine standard for smoked tobacco in real life
This project follows adults who smoke daily to see how a nationwide, very low nicotine standard would affect their smoking, health, and well-being over several years.
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Impact of a low nicotine standard on real-world tobacco use in New Zealand
A real-world study will follow adults who smoke to see how a mandated lower nicotine level across all smoked tobacco affects their smoking habits and health over several years.
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Sensory nerves and joint cells talk to each other in knee arthritis
This grant tests how nerve signals and joint cells interact in knee osteoarthritis, with a focus on CGRP pathways and how they affect pain and joint damage.
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POINTER-zzz: Sleep and brain health study for people at risk of Alzheimer’s disease
A large, long-term study is testing whether two lifestyle programs, including better sleep, can boost thinking skills in older adults at risk for Alzheimer's dementia.
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How immune cells in the brain may influence opioid use and relapse
A researcher is studying how certain brain-immune cells (CD8+ T cells) might drive opioid taking and relapse, with the goal of finding non-opioid targets to help people with opioid use disorder.
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ASPIRE: Making self-measured blood pressure work for primary care patients
A practical plan to help adults manage high blood pressure by using home blood pressure readings in regular clinic care.
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Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health
This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.
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Look AHEAD Aging Extension for older adults with type 2 diabetes
A study of people with type 2 diabetes and overweight or obesity to find ways to promote healthier aging and better quality of life in later years.
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cGMP production of FVIII-making placental cells to help people with Hemophilia A
A new, patient-friendly therapy aims to make FVIII-producing placental cells in the lab to help adults with Hemophilia A, potentially offering a longer-lasting and more affordable treatment.
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Development of antibodies to prevent disseminating Klebsiella pneumoniae infections
A short, patient-friendly proposal to create antibodies that could help prevent dangerous bloodstream infections caused by Klebsiella pneumoniae, especially in people with weakened immune systems.
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Pointer Neurovascular Extension in Alzheimer’s risk
A long-term study will follow people at risk for Alzheimer’s to see if a structured lifestyle program helps brain health by improving blood flow and nervous system function.
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Guidelines and toolkit to roll out population-wide genetic screening for cancer risk
A large study aims to create and test an online toolkit to help clinics implement population-wide genetic screening for hereditary cancer and cholesterol risk.
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Real-world impact of a lower nicotine standard on smoking in New Zealand
A large study in adults who smoke daily will follow how reducing nicotine in smoked tobacco changes their use, health, and well-being over several years.
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Using ECG and AI to find childhood cancer survivors at risk for late cardiomyopathy
This project uses routine ECG tracings plus artificial intelligence to spot childhood cancer survivors who may develop heart muscle disease years later.
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Common stem cell origin in Barrett's-related cancers
This research looks at whether a single stem cell type drives both esophageal and gastric cancers that arise from Barrett’s esophagus, with the aim of finding shared clues to prevent or treat these diseases.
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Understanding how brain epigenetics may predispose to risky drinking in primates
A primate study looks at how epigenetic changes in the brain before drinking might make some individuals more likely to develop heavy alcohol use later.
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How placental growth factor affects the blood-retina barrier in diabetic eye disease
A scientist plans to study how a protein called placental growth factor influences the blood-retina barrier in people with diabetes to help prevent vision loss.
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Ghrelin hormone and hippocampal changes in Alzheimer’s disease
This work looks at how changes in the hunger hormone ghrelin and its modifying enzyme (GOAT) relate to memory-region damage in people with Alzheimer’s disease.
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Leaking mitochondrial DNA that turns on brain immune cells in Alzheimer's
This research explains how fragments of mitochondrial DNA can switch on immune responses in the brain and contribute to inflammation in people with Alzheimer's.
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Understanding and addressing medical mistrust to boost HIV prevention for HLMSM
A multi-part study will explore why Hispanic/Latino gay, bisexual, and other men who have sex with men experience mistrust in medical care and test a culturally aligned plan to improve HIV testing and PrEP use in Mecklenburg County, NC.
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Solid-state nanopore tools to analyze vital sugars for bladder cancer care
A new technology uses tiny solid-state nanopores to measure glycosaminoglycans, like HA, from small patient samples to help understand bladder cancer biology.
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A new approach to improve HIV prevention and care in rural Appalachia
This project tests a community-based plan using CHWs and mobile tools to boost PrEP, doxyPEP, and condom use among MSM in rural Appalachia.
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Cannabis use and its benefits and risks for cancer patients in community clinics
This project follows cancer patients in community clinics to understand how cannabis use relates to symptoms, treatments, and safety.
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Improving Mobility After Revascularization in Peripheral Artery Disease
A data coordinating center plans to support a large multi-site trial that aims to improve mobility after revascularization in people with peripheral artery disease.
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Wake Forest NeuroNext Clinical Site (WAKENN)
A funded program at Wake Forest Health Sciences helps run and coordinate clinical studies for adults at multiple hospitals, aiming to improve how NeuroNEXT trials are conducted and enroll participants.
Quick answers
How many clinical trials run by Wake Forest University Health Sciences are recruiting right now?
147, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (146 trials), Australia (2 trials), Puerto Rico (1 trial), Sweden (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 15, Phase 4: 10, Phase 3: 8, Phase 1: 4. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.