Comparing treatments for hair loss in African-American women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the effectiveness of different treatment regimens for Central Centrifugal Cicatricial Alopecia (CCCA) in African-American women. Participants will be randomized into two groups: one receiving a topical steroid with an oral antibiotic and the other receiving a topical steroid with intralesional steroid injections, both followed by topical minoxidil after eight months. The study aims to analyze photos taken before and after treatment to assess the outcomes of these interventions. The goal is to determine which treatment combination yields better results for patients suffering from CCCA.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* African-American women, ages 18-60 years old
* with a clinical diagnosis and biopsy-proven CCCA, with Central Scalp Alopecia Scale severity 1 through 4 will be included in this study
* These subjects will be seen and treated in Wake Forest Baptist Health Dermatology Outpatient Clinic

Exclusion Criteria:

* Patients with other forms of hair loss in addition to CCCA will be excluded
* Other patients to be excluded are those with other forms of inflammatory scalp disease (with the exception of mild seborrheic dermatitis)
* patients who have had topical treatment for CCCA within the past 4 months (including topical steroids, topical minoxidil, or any other topical hair regrowth medication)
* patients who have been on a long-term oral antibiotics for hair loss within the past year
* patients who have undergone more than two rounds of intralesional steroid injections to the scalp in the past one year.

Where it's running

• Wake Forest Baptist Health Department of Dermatology
  Winston-Salem, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Amy J McMichael, MD — Wake Forest Baptist Health Department of Dermatology
• Study coordinator: Amy J McMichael, MD
• Email: amcmichael@wakehealth.edu
• Phone: 336.716.3926

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tirzepatide for Active Central Centrifugal Cicatricial Alopecia (CCCA)

  This pilot test will see if weekly tirzepatide can help adults with active CCCA regrow hair and reduce scarring.

  Recruiting at 2 sites Phase 2 Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT07734870

• Deucravacitinib for scarring hair loss (frontal fibrosing and central centrifugal alopecia)

  This trial will test whether taking deucravacitinib once daily for 48 weeks helps adults with frontal fibrosing alopecia or central centrifugal cicatricial alopecia.

  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07508488

• Topical delgocitinib 2% cream for Lichen Planopilaris and Central Centrifugal Cicatricial Alopecia

  This trial tests whether applying 2% delgocitinib cream twice daily is safe and changes scalp biomarkers in adults with Lichen Planopilaris or Central Centrifugal Cicatricial Alopecia over 48 weeks.

  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07487948

• Using a special LED cap to treat a type of hair loss in women

  This study is testing if a special LED cap can help middle-aged women with a type of hair loss called Central Centrifugal Cicatricial Alopecia by stopping hair loss and possibly encouraging regrowth.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT04764331

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.