Comparing treatments for hair loss in African-American women
Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study
This study is testing two different treatment combinations for hair loss in African-American women with Central Centrifugal Cicatricial Alopecia to see which one works better.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | Female |
| Sponsor | Wake Forest University Health Sciences Academic / other |
| Locations | 1 site (Winston-Salem, North Carolina) |
| Trial ID | NCT04207931 on ClinicalTrials.gov |
What this trial studies
This study examines the effectiveness of different treatment regimens for Central Centrifugal Cicatricial Alopecia (CCCA) in African-American women. Participants will be randomized into two groups: one receiving a topical steroid with an oral antibiotic and the other receiving a topical steroid with intralesional steroid injections, both followed by topical minoxidil after eight months. The study aims to analyze photos taken before and after treatment to assess the outcomes of these interventions. The goal is to determine which treatment combination yields better results for patients suffering from CCCA.
Who should consider this trial
Good fit: Ideal candidates are African-American women aged 18-60 with biopsy-proven CCCA and a severity scale of 1 to 4.
Not a fit: Patients with other forms of hair loss or inflammatory scalp diseases, as well as those who have recently undergone specific treatments for CCCA, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide effective treatment options for women suffering from CCCA, potentially improving hair regrowth and quality of life.
How similar studies have performed: Previous studies have shown varying degrees of success with similar treatment approaches for hair loss, but this specific comparison in CCCA is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * African-American women, ages 18-60 years old * with a clinical diagnosis and biopsy-proven CCCA, with Central Scalp Alopecia Scale severity 1 through 4 will be included in this study * These subjects will be seen and treated in Wake Forest Baptist Health Dermatology Outpatient Clinic Exclusion Criteria: * Patients with other forms of hair loss in addition to CCCA will be excluded * Other patients to be excluded are those with other forms of inflammatory scalp disease (with the exception of mild seborrheic dermatitis) * patients who have had topical treatment for CCCA within the past 4 months (including topical steroids, topical minoxidil, or any other topical hair regrowth medication) * patients who have been on a long-term oral antibiotics for hair loss within the past year * patients who have undergone more than two rounds of intralesional steroid injections to the scalp in the past one year.
Where this trial is running
Winston-Salem, North Carolina
- Wake Forest Baptist Health Department of Dermatology — Winston-Salem, North Carolina, United States (Recruiting)
Study contacts
- Principal investigator: Amy J McMichael, MD — Wake Forest Baptist Health Department of Dermatology
- Study coordinator: Amy J McMichael, MD
- Email: amcmichael@wakehealth.edu
- Phone: 336.716.3926
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.