Evaluating a combined approach to manage chronic pain
Official title: Pain Response Evaluation of a Combined Intervention to Cope Effectively (PRECICE)
Funded at Wake Forest University Health Sciences · NIH-9870024 · Data updated 2026-11-12
This study is looking at whether taking duloxetine along with online therapy can help people with chronic pain feel better, and it includes some support to help you stick with the therapy; you'll be randomly placed in one of three groups to see which approach works best over six months.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2020 |
| Award (this year) | $3,929,419 |
| NIH project number | 1UG3NR019196-01 |
| Project ID | NIH-9870024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing chronic musculoskeletal pain who are seeking new treatment options.
✕Less likely to help
Patients who do not have chronic musculoskeletal pain or those who are already receiving effective treatment may not benefit from this research.
What this research studies
This research investigates the effectiveness of a combination therapy involving duloxetine and web-based cognitive behavioral therapy (CBT) for patients suffering from chronic musculoskeletal pain (CMP). The study aims to enhance treatment outcomes by incorporating motivational interviewing to support adherence to the CBT program. Participants will be randomly assigned to receive either the combination therapy with nurse support, combination therapy without support, or duloxetine alone over a 24-week period. The goal is to determine if the combined approach leads to better pain management compared to duloxetine alone.
Why it matters
Potential benefit: If successful, this research could provide a more effective treatment option for patients with chronic musculoskeletal pain, potentially improving their quality of life.
How similar studies have gone: Previous research has shown promise in using combination therapies for chronic pain management, suggesting that this approach may yield beneficial results.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Ang, Dennis Chua — Wake Forest University Health Sciences
- Study coordinator: Ang, Dennis Chua
Related research
Other NIH-funded projects on the same topics.
-
Drd3 gene variants and cocaine seeking in rats
A study in rats will map different Drd3 gene variants to how cocaine-seeking and taking behavior is influenced, aiming to uncover targets for treating cocaine use disorder.
-
Intensive dental care during cancer follow-up to protect teeth after head and neck radiation
A program delivered in oncology clinics to provide fluoride varnish and dental follow-up aims to reduce tooth decay and improve oral health and quality of life for head and neck cancer patients after radiation therapy.
-
Wake Forest NCORP Cancer Center Research Base
A patient-focused opportunity to advance real-world cancer care through community-based studies that address how cancer and its treatments affect daily life and well-being.
-
Hybrid approach to peer-supported mood and incentive program to reduce HIV risk among women who inject drugs
A pilot program tests a combined peer-supported mood-boosting approach with contingency management to help stimulant-using women who inject drugs reduce HIV risk.
-
Coordinating Center for the MoTrPAC project
A large nationwide effort seeks to map how physical activity changes the body at the molecular level, with a coordinating center that handles data, biospecimens, and collaboration across sites.
-
HeartShare HFpEF Clinical Center at Wake Forest
A large, patient-centered program at Wake Forest to deeply profile people with HFpEF and healthy controls to uncover new disease mechanisms and treatment targets.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.