Evaluating the risk of blood cancers in firefighters
Official title: Pre-malignant States to Hematologic Malignancies in Firefighters
Run by Wake Forest University Health Sciences · NCT06870760 · Data updated 2026-11-12
This study is testing if firefighters who have been exposed to harmful substances are at a higher risk for blood cancers and related conditions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 49 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Wake Forest University Health Sciences Academic / other |
| Locations | 1 site (Charlotte, North Carolina) |
| Status | Recruiting |
| Started | June 23, 2026 |
| Main results expected | April 2027 |
| Study ends | April 2027 |
| Registry record updated | July 13, 2026 |
| Trial ID | NCT06870760 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are firefighters aged 40-49 with a minimum of five years of experience at the Charlotte Fire Department.
✕Probably not a fit
Patients currently diagnosed with a hematologic malignancy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess whether firefighters' exposure to hazardous compounds increases the incidence of pre-malignant hematological conditions, which may lead to hematologic malignancies. Participants aged 40-49 from the Charlotte Fire Department with at least five years of service will undergo lab tests to evaluate for clonal hematopoiesis and monoclonal gammopathy. Additionally, buccal swabs and blood samples will be collected for future research. If any abnormalities are detected, participants will receive referrals for further diagnostic assessments.
Why it matters
Potential benefit: If successful, this study could lead to early detection and management of pre-malignant conditions in firefighters, potentially reducing the risk of developing blood cancers.
How similar studies have gone: While there is ongoing research into the health impacts of occupational exposures in firefighters, this specific focus on pre-malignant hematological conditions is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Written informed consent and HIPAA authorization for release of personal health information. 2. Age ≥ 40-49 years at the time of consent (self-reported) 3. Ability of the participant to understand and comply with study procedures for the entire length of the study 4. Currently employed by Charlotte Fire Department (CFD) with at least 5 years on-the -job experience (self-reported) Exclusion Criteria: Anyone with a current diagnosis of a hematologic malignancy will be excluded.
Where it's running
-
Levine Cancer Institute
Charlotte, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Larry Druhan, PhD — Wake Forest University Health Sciences
- Study coordinator: Megan Lattanze
- Email: Megan.Lattanze@advocatehealth.org
- Phone: 980-442-4239
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.