Clinical trial Recruiting at 44 sites Interventional Ages 18 and up

COACH-APP: education and mentorship to help advanced practice providers join community oncology clinical teams

Official title: Building Capacity Within the NCORP Network Through an Education and Mentorship Intervention for Advanced Practice Providers (COACH-APP)

Run by Wake Forest University Health Sciences · NCT06904391 · Data updated 2026-11-12

This program will test whether focused education and structured mentorship helps nurse practitioners and physician assistants in community oncology feel more confident taking part in clinical research.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment97 (estimated)
SponsorWake Forest University Health Sciences
Academic / other
Locations44 sites (Newark, Delaware and 43 other locations)
StatusRecruiting
StartedSeptember 5, 2025
Main results expectedJune 30, 2028
Study endsJune 30, 2028
Registry record updatedOctober 5, 2026
Trial IDNCT06904391 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal participants are practicing nurse practitioners or physician assistants at NCORP-affiliated community oncology practices who are registered as non-physician investigators (NPIVR), can enroll their practice in OPEN, and can commit about two hours per month for 12 months.

Probably not a fit

Practices without research infrastructure, APPs not registered as NPIVR, or APPs unable to commit the required time or administrative enrollment steps are unlikely to benefit from the intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized intervention compares a combined education plus structured mentorship program (COACH-APP) to an education-only control for advanced practice providers (APPs) in NCORP community oncology practices. The primary outcome is change in research self-efficacy (RSE) from baseline to 12 months post-randomization. Secondary outcomes include NCORP engagement, APP ratings of research team integration (ACE-15), practice-level trial activity over 24 months, and qualitative measures of acceptability and feasibility among participants and mentors. APPs in the intervention receive focused training plus mentor support while control sites receive education materials and usual support.

Why it matters

Potential benefit: If successful, the program could increase APP involvement in clinical research at community sites, improving patient access to trials and potentially enhancing care delivered locally.

How similar studies have gone: Educational and mentorship programs have shown promise for improving clinician engagement in research in other settings, but targeted randomized evidence focused on APPs within NCORP community oncology is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* APP PRACTICE: Must have one practicing APP who can dedicate approximately 2 hours/month to participate in the intervention and study activities over a 12-month period, supported by their direct supervisor via the APP Support Statement
* APP PRACTICE: Must attest to research infrastructure that can support APP trial enrollment, as declared on the APP Practice Attestation
* APP PRACTICE: Must have submitted the APP Practice Attestation within the Study Interest Survey
* APP PRACTICE: Must have received the required APP practice ID for Oncology Patient Enrollment Network (OPEN) enrollment in the Study Selection Email prior to enrollment
* APP PRACTICE: Must enroll eligible practice site(s) in OPEN within 14 days of receiving the Study Selection Email.
* APP: Practicing nurse practitioner (NP) or physician assistant (PA) registered as an active non-physician investigators (NPIVR) within the National Cancer Institute (NCI) Registration and Credential Repository (RCR)
* APP: Treats oncology patients at practice that is actively recruiting to NCORP and/or NCTN trials
* APP: Not planning to leave their clinical position within the APP practice (defined as one or more NCORP affiliate or sub-affiliate site\[s\] where the APP participating in the study sees patients and clinical research activities occur) in the next 12 months at enrollment
* APP: Willing to participate in a 30-minute recorded phone interview, if selected
* APP: Completed and submitted the APP Attestation within the Study Interest Survey
* APP: Completed and submitted an APP Support Statement from their direct supervisor approving participation in this study, within the Study Interest Survey
* APP: Identify and obtain signed Research Care (RC) Team Acknowledgements from two members (defined below) of their research care team to assist them in this study. The RC team for this study will consist of an oncologist and clinical research professional (i.e., clinical research coordinator, clinical research associate clinical research nurse, etc.) that the APP collaborated with over the past 6 months or could collaborate with in the future to enroll patients on NCORP and/or NCTN trials
* APP: Must have received the required APP practice ID for OPEN enrollment in the Study Selection Email
* APP: Must enroll consented APPs in OPEN within 14 days of receiving the Study Selection Email
* MENTOR: Must be a practicing APP chosen by the WF-2403 COACH-APP Study MPIs
* MENTOR: Must have the following criteria:

  * Clinical practice experience in a practice that enrolls to NCORP and/or NCTN trials.
  * Participation in a leadership role within NCTN or NCORP (i.e., serving on a Research Base committee, working group, taskforce or as a site PI)
  * Willing to complete COACH-APP mentor training.
  * Willing to complete a 30-minute recorded phone interview about their experience with the COACH-APP intervention
* RESEARCH CARE TEAM INTERVIEW: Must be an identified member of the Research Care Team for an APP assigned to the COACH-APP intervention arm. The Research Care Team will be reviewed by the APP in the 12 month survey for any changes
* RESEARCH CARE TEAM INTERVIEW: Willing to participate in a recorded phone interview (approximately 30 minutes) to assess their perceptions of the COACH-APP intervention, including feasibility, acceptability, and impact

Exclusion Criteria:

* APP PRACTICE: APP practice has an APP serving as a COACH-APP intervention mentor
* APP PRACTICE: Another APP at the same APP practice is already enrolled in this study (i.e., only 1 APP is allowed per APP practice)
* APP PRACTICE: Affiliate/sub-affiliate site(s) within this APP practice are already enrolled or are intended to be enrolled in this study under another APP practice
* APP: Has already completed the SWOG APP workshop
* APP: Served as a site principal investigator (PI) for an NCORP or NCTN study at any time
* APP: Participated as a presenter for the SWOG APP workshop
* APP: Participated on the planning committee for The Advanced Practice Provider Clinical Trials Research Manual
* APP: Participated on the planning committee for the SWOG APP workshop
* APP: Past or current member of SWOG APP Task Force Committee
* APP: Past or current member of Eastern Cooperative Oncology Group- American College of Radiology Imaging Network (ECOG-ACRIN) APP Committee
* MENTOR: Must not work at NC002-Wake Forest University Health Sciences or its affiliate/subaffiliate sites

Where it's running

  • Helen F Graham Cancer Center
    Newark, Delaware, United States
    Recruiting
  • Liberty County Cancer Care
    Hinesville, Georgia, United States
    Recruiting
  • Regional Cancer Care - Jesup
    Jesup, Georgia, United States
    Recruiting
  • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
    Savannah, Georgia, United States
    Recruiting
  • Queen's Medical Center
    Honolulu, Hawaii, United States
    Recruiting
  • University of Hawaii Cancer Center
    Honolulu, Hawaii, United States
    Recruiting
Show 38 more locations
  • The Queen's Medical Center - West Oahu
    ‘Ewa Beach, Hawaii, United States
    Recruiting
  • Illinois Cancer Care-Bloomington
    Bloomington, Illinois, United States
    Recruiting
  • John H Stroger Jr Hospital of Cook County
    Chicago, Illinois, United States
    Recruiting
  • Illinois Cancer Care - Eureka
    Eureka, Illinois, United States
    Recruiting
  • Illinois CancerCare-Galesburg
    Galesburg, Illinois, United States
    Recruiting
  • Illinois CancerCare-Macomb
    Macomb, Illinois, United States
    Recruiting
  • SSM Health Good Samaritan
    Mount Vernon, Illinois, United States
    Recruiting
  • Illinois Cancer Care-Pekin
    Pekin, Illinois, United States
    Recruiting
  • Illinois CancerCare-Peoria
    Peoria, Illinois, United States
    Recruiting
  • Illinois Cancer Care - Washington
    Washington, Illinois, United States
    Recruiting
  • HaysMed
    Hays, Kansas, United States
    Recruiting
  • University of Kansas Cancer Center-Overland Park
    Overland Park, Kansas, United States
    Recruiting
  • University of Kansas Hospital-Westwood Cancer Center
    Westwood, Kansas, United States
    Recruiting
  • Harold Alfond Center for Cancer Care
    Augusta, Maine, United States
    Recruiting
  • MaineHealth Cancer Care and IV Therapy - Brunswick
    Brunswick, Maine, United States
    Recruiting
  • MaineHealth Maine Medical Center - Portland
    Portland, Maine, United States
    Recruiting
  • MaineHealth Maine Medical Center- Scarborough
    Scarborough, Maine, United States
    Recruiting
  • Maine Health Cancer Care and IV Therapy - South Portland
    South Portland, Maine, United States
    Recruiting
  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
    Chelsea, Michigan, United States
    Recruiting
  • Corewell Health Reed City Hospital
    Reed City, Michigan, United States
    Recruiting
  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
    Ypsilanti, Michigan, United States
    Recruiting
  • Sanford Joe Lueken Cancer Center
    Bemidji, Minnesota, United States
    Recruiting
  • Baptist Memorial Hospital and Cancer Center-Golden Triangle
    Columbus, Mississippi, United States
    Recruiting
  • Mercy Hospital Joplin
    Joplin, Missouri, United States
    Recruiting
  • University of Kansas Cancer Center - Briarcliff
    Kansas City, Missouri, United States
    Recruiting
  • University of Kansas Cancer Center - North
    Kansas City, Missouri, United States
    Recruiting
  • Lovelace Women's Hospital
    Albuquerque, New Mexico, United States
    Recruiting
  • Lovelace Women's Hospital
    Albuquerque, New Mexico, United States
    Recruiting
  • Wake Forest NCORP Research Base
    Winston-Salem, North Carolina, United States
    Recruiting
  • Lewistown Hospital
    Lewistown, Pennsylvania, United States
    Recruiting
  • Prisma Health Cancer Institute - Faris
    Greenville, South Carolina, United States
    Recruiting
  • Prisma Health Cancer Institute - Eastside
    Greenville, South Carolina, United States
    Recruiting
  • Gibbs Cancer Center-Pelham
    Greer, South Carolina, United States
    Recruiting
  • Spartanburg Medical Center
    Spartanburg, South Carolina, United States
    Recruiting
  • Sanford Cancer Center Oncology Clinic
    Sioux Falls, South Dakota, United States
    Recruiting
  • Baptist Memorial Hospital and Cancer Center-Memphis
    Memphis, Tennessee, United States
    Recruiting
  • VCU Massey Comprehensive Cancer Center
    Richmond, Virginia, United States
    Recruiting
  • Saint Vincent Hospital Cancer Center at Saint Mary's
    Green Bay, Wisconsin, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.