Sleep and mood links in Fragile X Syndrome
Official title: Sleep and Mood Dysregulation in Fragile X Syndrome: A Multidisciplinary Investigation of Behavioral and Neurobiological Correlates
Funded at Wake Forest University Health Sciences · NIH-11456853 · Data updated 2026-11-12
A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 11, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $417,249 |
| NIH project number | 1R21HD123275-01 |
| Project ID | NIH-11456853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Fragile X–associated autism (ASD) who experience sleep disturbances and mood symptoms.
✕Less likely to help
Participants without sleep disturbances or mood symptoms may have limited direct benefit.
What this research studies
This project will look at how sleep patterns connect with mood and depressive-like behaviors in Fragile X autism. Researchers will use sleep studies and brain activity monitoring to identify biomarkers that could help predict treatment response. The goal is to find clues that could guide better sleep and mood interventions for ASD with Fragile X features. The findings may pave the way for new approaches to diagnose and treat mood issues in this population.
Why it matters
Potential benefit: If successful, the study could lead to better screening and personalized interventions for mood and sleep problems in Fragile X–associated autism.
How similar studies have gone: Previous research in ASD and Fragile X suggests sleep and mood are interconnected, but targeted biomarkers are still emerging.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Raab-Graham, Kimberly Frances — Wake Forest University Health Sciences
- Study coordinator: Raab-Graham, Kimberly Frances
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.