Head-frame pain relief: Suzetrigine vs. acetaminophen for adults
Official title: A Randomized Controlled Trial Comparing Suzetrigine and Acetaminophen for Reducing Pain During Local Anesthetic Infiltration and Head Frame Application
Run by Wake Forest University Health Sciences · NCT07525219 · Data updated 2026-11-12
This study tests whether Suzetrigine or acetaminophen better reduces pain during stereotactic head frame placement in adults.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Wake Forest University Health Sciences Academic / other |
| Locations | 1 site (Winston-Salem, North Carolina) |
| Status | Recruiting |
| Started | June 22, 2026 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | July 28, 2026 |
| Trial ID | NCT07525219 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for procedures requiring stereotactic head frame placement who are eligible to receive either Suzetrigine or acetaminophen as part of standard care.
✕Probably not a fit
Patients who do not respond to the chosen analgesic or have adverse reactions may not experience a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a Phase 3 interventional trial comparing two non-opioid pain relief options given before stereotactic head frame placement. Participants are adults undergoing a standard head-frame–based procedure and are randomly assigned to receive Suzetrigine or acetaminophen to see which provides greater relief from procedure-related pain. The trial uses routine clinical procedures and measures pain scores to determine relative efficacy and safety. Both medications are already used to prevent pain around similar procedures, and this study seeks to establish which option is more effective in this context.
Why it matters
Potential benefit: If Suzetrigine proves superior, patients may experience better pain control during head-frame placement and potentially reduced need for additional analgesia.
How similar studies have gone: Prior pain-prevention studies for head-frame or similar procedures have shown promise with non-opioid analgesics, but direct comparisons like this are relatively novel for this exact setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients scheduled for a standard of care procedure requiring a stereotactic head frame to be placed Exclusion Criteria: * Patients not scheduled for a standard of care procedure requiring a stereotactic head frame to be placed will not be approached
Where it's running
-
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Stephen B Tatter, MD — Wake Forest University Health Sciences
- Study coordinator: Wendy Jenkins, BSN RN, CCRC
- Email: Wendy.Jenkins@AdvocateHealth.org
- Phone: 336.716.3842
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Quadro‑Iliac Plane Block versus Erector Spinae Plane for pain after total hip replacement
This will test whether the quadro‑iliac plane block or the erector spinae plane block controls pain better after total hip replacement in adults having spinal anesthesia.
-
Continuous versus bolus ibuprofen for pain after laparoscopic surgery
This trial tests whether giving ibuprofen as a continuous infusion instead of intermittent bolus doses reduces pain and opioid use for adults having elective laparoscopic surgery.
-
Cognitive changes after BCMA CAR-T in multiple myeloma
This study tests whether cognitive function changes over time in adults with relapsed or refractory multiple myeloma who receive BCMA CAR-T therapy.
-
Pelashield vs Xeroform for donor-site dressings in skin graft patients
A randomized, patient-treated trial tests whether Pelashield, a new skin graft dressing, can better control pain and improve donor-site appearance compared with the standard Xeroform in split-thickness skin grafts.
-
Optimizing how patients get blood pressure cuffs and how they log readings in primary care
We’re testing the best way to provide a standard, validated blood pressure cuff and the easiest way for patients to log their readings in routine primary care among adults with uncontrolled hypertension.
-
Two hospital-to-home transition programs for older adults and their family caregivers
Aims to see if adding family support to a patient-focused discharge plan helps older adults stay at home safely and reduces ER visits or hospital readmissions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.