Using antidepressants to prevent depression after fragility fractures in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to assess the feasibility of prescribing serotonin-norepinephrine reuptake inhibitors (SNRIs) to older patients with lower extremity fragility fractures at the time of discharge. It will explore barriers to patient enrollment and medication prescription, evaluate the prevalence of depressive symptoms in this population, and develop a transition of care plan for those requiring further mental health support. Participants will be screened for depression, prescribed Duloxetine, and monitored for medication compliance and outcomes over a year.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Geriatric (greater than or equal to 65 years old)
* Lower extremity fragility fractures managed operatively

Exclusion Criteria:

* Polytrauma
* Pathological fractures
* Patients on hospice
* Patients with previously diagnosed psychiatric disorders
* Patients with previously diagnosed dementia
* Patients already taking Selective serotonin reuptake inhibitors (SSRI)s and Serotonin- norepinephrine reuptake inhibitors (SNRI)s
* Patients already taking mood stabilizing medication
* Unable to provide informed consent (no use of a legal authorized representative)
* Patients with pre-existing life limiting diagnoses (cancer, etc.)

Where it's running

• Wake Forest University Health Sciences
  Winston-Salem, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Rachel Seymour, PhD — Wake Forest University Health Sciences
• Study coordinator: Erica Grochowski, MPH
• Email: Erica.Grochowski@advocatehealth.org
• Phone: 704-403-4980

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.