Improving physical function in older adults with advanced chronic kidney disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot randomized controlled trial will enroll mobility-limited older adults with advanced CKD to compare a 12-week high-velocity resistance training (HVRT) program against an attention control of weekly healthy-lifestyle group sessions. The HVRT group will perform low-load, functional movements performed "as fast as possible" to target muscle power, while the control group receives education and social contact. The trial focuses on feasibility and safety and will collect preliminary outcome data on muscle power and physical function to inform a larger efficacy trial. Participants must be able to exercise safely, not be on dialysis, and attend in-person sessions at Wake Forest in Winston-Salem, NC.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic kidney disease stages 3-5
* Capacity to complete physical exercise
* Lives within 20 miles of Wake Forest Reynolda Campus
* Fluent English speaker
* Does not plan to travel outside of home area for an extended period of time during study
* Willing to be randomized to either intervention group

Exclusion Criteria:

* Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months
* Dependent on a wheelchair
* Current participation in a resistance training program
* Joint replacement or orthopedic surgery in the previous 6 months or planning to have surgery in the next 6 months months
* Absolute contraindications to exercise testing according to ACSM:

Acute myocardial infarction within the past 6 months Ongoing unstable angina Uncontrolled cardiac arrhythmia with hemodynamic compromise Active endocarditis Symptomatic severe aortic stenosis Decompensated heart failure Acute pulmonary embolism, pulmonary infarction, or deep venous thrombosis Acute myocarditis or pericarditis Acute aortic dissection

* Parkinson's disease
* Respiratory disease requiring oxygen
* Cancer requiring treatment
* Currently receiving physical therapy or cardiopulmonary rehabilitation
* Type I or insulin dependent Type II Diabetes
* Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS)
* Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence

Where it's running

• Wake Forest University Health Sciences
  Winston-Salem, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Eliott Arroyo, PhD — Wake Forest University Health Sciences
• Study coordinator: Rodrigo Lion
• Email: epicstudy@wfu.edu
• Phone: 336-758-3784

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.