Mobile low-dose CT screening for lung cancer in younger adults
Official title: Lung B.A.S.E.S 4 Life Mobile Low-dose Computed Tomography (LDCT) Screening: Assessing Incidence and Stage of Lung Cancer Diagnosis in Subjects Ages 40-54 With a 30 Pack Year History or More Within North and South Carolina
Run by Wake Forest University Health Sciences · NCT04577599 · Data updated 2026-11-12
This study is testing if a mobile low-dose CT scan can help find lung cancer earlier in younger adults aged 40-54 who have a significant history of smoking.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 54 Years |
| Sex | All |
| Enrollment | 1160 (estimated) |
| Sponsor | Wake Forest University Health Sciences Academic / other |
| Locations | 1 site (Charlotte, North Carolina) |
| Status | Recruiting |
| Started | January 7, 2021 |
| Main results expected | October 2028 |
| Study ends | October 2028 |
| Registry record updated | July 13, 2026 |
| Trial ID | NCT04577599 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 40-54 with a smoking history of 30 pack years or more, who are currently smoking or have quit within the last 15 years.
✕Probably not a fit
Patients with a known diagnosis of lung cancer in the past 5 years or contraindications to low-dose CT scans will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of mobile low-dose computed tomography (LDCT) screening for lung cancer in individuals aged 40-54 with a significant smoking history. It aims to determine the lung cancer diagnosis rate at the first screening and subsequent screenings, while also assessing the impact of demographic and socioeconomic factors on screening outcomes. The study plans to enroll approximately 1160 participants to identify 174 evaluable subjects, focusing on a high-risk population in North and South Carolina.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of lung cancer in younger high-risk individuals, potentially improving survival rates.
How similar studies have gone: Previous studies have shown that low-dose CT screening can significantly improve lung cancer detection rates in older populations, suggesting potential success in this younger demographic.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject must meet all the following applicable inclusion criteria to participate in this study: 1. Written informed consent and HIPAA authorization for release of personal health information. NOTE: HIPAA authorization may be included in the informed consent or obtained separately. 2. Age 40-54 years at the time of consent. 3. A positive smoking history of greater/equal to 30 pack years and they are either currently smoking or have quit within the last 15 years. 4. Ability to read and understand the English and/or Spanish language. 5. Ability to understand and comply with study procedures for the entire length of the study. Exclusion Criteria: * Subjects meeting any of the criteria below may not participate in the study: 1. Known diagnosis of lung cancer in the past 5 years. 2. Any known contraindication to having a low-dose CT Scan. 3. Known pregnancy.
Where it's running
-
Levine Cancer Institute
Charlotte, North Carolina, United States Recruiting
Study contacts
- Principal investigator: Daniel Carrizosa, MD — Lci
- Study coordinator: Darcy Doege, RN
- Email: Darcy.Doege@atriumhealth.org
- Phone: 913-424-6431
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.