Improving Mobility After Revascularization in Peripheral Artery Disease
Official title: 2/2 Improving Mobility After Revascularization in Peripheral Artery Disease: The IMPACT PAD Trial
Funded at Wake Forest University Health Sciences · NIH-11404976 · Data updated 2026-11-12
A data coordinating center plans to support a large multi-site trial that aims to improve mobility after revascularization in people with peripheral artery disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $537,757 |
| NIH project number | 5U24HL169563-03 |
| Project ID | NIH-11404976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with peripheral artery disease undergoing revascularization and willing to participate in a multi-center clinical trial with follow-up.
✕Less likely to help
Patients not undergoing revascularization or those who cannot participate in long-term follow-up may not benefit.
What this research studies
This grant supports Wake Forest University School of Medicine's team as the data coordinating center for IMPACT PAD, a 386-participant, 2x2 factorial trial. The center will handle study design input, data management, recruitment support, follow-up, safety monitoring, and protocol/document development to ensure high-quality, standardized processes across seven field sites. The work is centered on coordinating complex multi-site operations to advance how mobility is improved after vascular procedures in PAD patients. By maintaining rigorous data integrity and collaboration with the Data Safety Monitoring Board and other committees, the DCC aims to enable reliable, patient-focused results. The grant emphasizes long-term trial management and methodological excellence to translate findings into improved patient care.
Why it matters
Potential benefit: If successful, the trial could lead to clearer guidelines and improved mobility for people recovering from procedures for PAD.
How similar studies have gone: Previous large multi-center trials and epidemiologic research support the feasibility of such coordinated efforts in PAD care.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Ambrosius, Walter T — Wake Forest University Health Sciences
- Study coordinator: Ambrosius, Walter T
Related research
Other NIH-funded projects on the same topics.
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Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
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-
Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life
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Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health
This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.
-
Enhancing muscle energy to help leg function in PAD
A study to boost how muscle mitochondria work in people with peripheral artery disease to improve walking and leg function.
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Low-dose colchicine for people with peripheral artery disease to reduce heart and limb risks
A large international study will test whether a low daily dose of colchicine can lower heart and limb complications for people with peripheral artery disease.
-
Low-dose colchicine for reducing vascular risk in people with PAD
A large international study will test whether a daily low dose of colchicine can lower heart and limb-related risks for people with peripheral artery disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.