How mitochondrial function relates to resilience in ovarian and endometrial cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, non-randomized pilot focused on feasibility of measuring physical and cognitive resilience and mitochondrial bioenergetics in patients aged 50 and older with newly diagnosed FIGO stage II–IV ovarian or endometrial cancer. Participants complete pre- and post-treatment measures including the Short Physical Performance Battery, handgrip strength, ESAS-r symptom scores, and cognitive testing (ICCTF battery and NAB Naming Test). Blood is collected at baseline and muscle tissue is obtained at the time of surgery for correlative mitochondrial respiration studies. Clinical care follows standard neoadjuvant chemotherapy, tumor-reduction surgery, and adjuvant chemotherapy while the study evaluates whether these measurements can be collected and related to resilience outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to understand and willingness to sign an IRB-approved informed consent
* Age ≥50 years at the time of enrollment
* Newly diagnosed or suspected FIGO Stage II-IV ovarian/primary peritoneal/fallopian tube carcinoma of any histological subtype OR FIGO Stage II-IV endometrial carcinoma of any histological subtype
* Planned, standard of care treatment consisting of neoadjuvant chemotherapy, tumor reduction surgery, and adjuvant chemotherapy OR tumor reduction surgery with adjuvant chemotherapy
* Ability to read and understand the English language

Exclusion Criteria:

* Previously treated for ovarian or endometrial cancer
* History of brain metastases, whole brain irradiation, poorly controlled psychiatric disorders defined by hospitalization within the last 3 months for psychiatric diagnoses, traumatic brain injury, cerebrovascular event, or dementia
* Currently taking anti-amyloid agents, cholinesterase inhibitors, or glutamate regulator
* Documented physical or psychological comorbidity that would limit participant's ability to understand or comply with study procedures for the entire length of the study

Where it's running

• Atrium Health Levine Cancer
  Charlotte, North Carolina, United States Recruiting
• Atrium Health Wake Forest Baptist Comprehensive Cancer Center
  Winston-Salem, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Bumsoo Ahn, PhD — Wake Forest University Health Sciences
• Study coordinator: Brandy Baker
• Email: brandy.baker@advocatehealth.org
• Phone: (336) 713-8941

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.