HeartShare HFpEF Clinical Center at Wake Forest
Official title: Wake Forest Atrium HeartShare Clinical Center
Funded at Wake Forest University Health Sciences · NIH-11528823 · Data updated 2026-11-12
A large, patient-centered program at Wake Forest to deeply profile people with HFpEF and healthy controls to uncover new disease mechanisms and treatment targets.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project start | September 10, 2021 |
| Project end | January 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $411,207 |
| NIH project number | 3U01HL160272-05S1 |
| Project ID | NIH-11528823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with HFpEF and suitably matched control participants without HFpEF.
✕Less likely to help
Healthy individuals not experiencing HFpEF may not receive direct benefits, though they contribute to a robust comparison group.
What this research studies
This project centers on building a big, well-characterized group of people with heart failure with preserved ejection fraction (HFpEF) and matched controls. Researchers will collect detailed clinical data and advanced biological information to reveal subtypes and potential new targets for therapy. The Wake Forest Atrium HFpEF team will lead recruitment, phenotyping, and coordination within the HeartShare network across multiple sites. The work aims to translate insights into better understanding and eventually better care for HFpEF patients. Participation would involve consenting to comprehensive assessments and sharing health information as part of a national research effort.
Why it matters
Potential benefit: If successful, patients with HFpEF could receive more precise diagnoses and access to targeted therapies in the future.
How similar studies have gone: Past HFpEF efforts have built large cohorts and deep phenotyping, but this program seeks to accelerate discovery with a larger, more diverse dataset.
Where this research is happening
-
Wake Forest University Health Sciences
Winston-Salem, United States Active
Researchers
- Principal investigator: Kitzman, Dalane W — Wake Forest University Health Sciences
- Study coordinator: Kitzman, Dalane W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.